nach oben

Erschienen in:

01.06.2015

Strategies to improve success of pediatric cancer cooperative group quality of life studies: a report from the Children’s Oncology Group

verfasst von: Puja G. Whitlow, Mae Caparas, Patricia Cullen, Christine Trask, Fiona Schulte, Leanne Embry, Rajaram Nagarajan, Donna L. Johnston, Lillian Sung

Erschienen in: Quality of Life Research | Ausgabe 6/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Quality of life (QoL) has been increasingly emphasized in National Cancer Institute (NCI)-sponsored multisite clinical trials. Little is known about the outcomes of these trials in pediatric cancer. Objectives were to describe the proportion of Children’s Oncology Group (COG) QoL studies that successfully accrued subjects and were analyzed, presented or published.

Methods

We conducted a survey to describe outcomes of COG QoL studies. We included studies that contained at least one QoL assessment and were closed to patient accrual at the time of survey dissemination. Respondents were the investigators most responsible for the QoL aim.

Results

Sixteen studies were included; response rate was 100 %. Nine (56 %) studies were embedded into a cancer treatment trial. Only 3 (19 %) studies accrued their intended sample size. Seven (44 %) studies were analyzed, 9 (56 %) were presented, and 6 (38 %) were published.

Conclusions

NCI-sponsored pediatric QoL studies have high rates of failure to accrue. Many were not analyzed or disseminated. Using these data, strategies have been implemented to improve conduct in future trials. Monitoring of QoL studies is important to maximize the chances of study success.

Nur mit Berechtigung zugänglich

Adamson, P. C. (2013). The Children’s Oncology Group’s 2013 five year blueprint for research. Pediatric Blood and Cancer, 60, 955–956.PubMedCrossRef

Ward, E., Desantis, C., Robbins, A., et al. (2014). Childhood and adolescent cancer statistics, 2014. CA: A Cancer Journal for Clinicians, 64, 83–103.

Linabery, A. M., & Ross, J. A. (2008). Childhood and adolescent cancer survival in the US by race and ethnicity for the diagnostic period 1975–1999. Cancer, 113, 2575–2596.PubMedCentralPubMedCrossRef

Tomlinson, D., Bartels, U., Gammon, J., et al. (2011). Chemotherapy versus supportive care alone in pediatric palliative care for cancer: Comparing the preferences of parents and health care professionals. CMAJ, 183, E1252–E1258.PubMedCentralPubMedCrossRef

The WHOQOL Group. (1998). The world health organization quality of Life assessment (WHOQOL). Development and psychometric properties. Social Science and Medicine, 46, 1569–1585.CrossRef

Vanhoff, D., Hesser, T., Kelly, K. P., et al. (2013). Facilitating accrual to cancer control and supportive care trials: The clinical research associate perspective. BMC Medical Research Methodology, 13, 154.PubMedCentralPubMedCrossRef

Schoot, R. A., van Ommen, C. H., Caron, H. N., et al. (2012). Accrual in supportive care trials in pediatric oncology, a challenge! Supportive Care in Cancer, 20, 3149–3153.PubMedCentralPubMedCrossRef

Heiney, S.P., Adams, S.A., Cunningham, J.E., et al. (2006). Subject recruitment for cancer control studies in an adverse environment. Cancer Nursing 29: 291–299; quiz 300–291.

Palesh, O., Demark-Wahnefried, W., Mustian, K., et al. (2011). Conducting cancer control and survivorship research via cooperative groups: A report from the American Society of Preventive Oncology. Cancer Epidemiol Biomarkers Prev, 20, 1050–1055.PubMedCentralPubMedCrossRef

10.

Carter, A., Landier, W., Schad, A., et al. (2008). Successful coordination and execution of nontherapeutic studies in a cooperative group setting: Lessons learned from Children’s Oncology Group studies. Cancer Epidemiol Biomarkers Prev, 17, 1665–1673.PubMedCentralPubMedCrossRef

11.

Johnston, D. L., Nagarajan, R., Caparas, M., et al. (2013). Reasons for non-completion of health related quality of life evaluations in pediatric acute myeloid leukemia: A report from the Children’s Oncology Group. PLoS ONE, 8, e74549.PubMedCentralPubMedCrossRef

Titel: Strategies to improve success of pediatric cancer cooperative group quality of life studies: a report from the Children’s Oncology Group
verfasst von: Puja G. Whitlow
Mae Caparas
Patricia Cullen
Christine Trask
Fiona Schulte
Leanne Embry
Rajaram Nagarajan
Donna L. Johnston
Lillian Sung
Publikationsdatum: 01.06.2015
Verlag: Springer International Publishing
Erschienen in: Quality of Life Research / Ausgabe 6/2015
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-014-0855-9

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2015

Predictors of health-related quality of life perceived by end-stage renal disease patients under online hemodiafiltration

Development of the Alcohol Quality of Life Scale (AQoLS): a new patient-reported outcome measure to assess health-related quality of life in alcohol use disorder

Cross-cultural measurement equivalence of the EQ-5D-5L items for English-speaking Asians in Singapore

The impact of tuberculosis on health utility: a longitudinal cohort study

The relationship among caregiving characteristics, caregiver strain, and health-related quality of life: evidence from the Survey of the Health of Wisconsin

Psychometric assessment of health-related quality of life and symptom experience in HIV patients treated with antiretroviral therapy