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01.12.2017 | Case report | Ausgabe 1/2017 Open Access

BMC Infectious Diseases 1/2017

Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes

Zeitschrift:
BMC Infectious Diseases > Ausgabe 1/2017
Autoren:
Tsuyoshi Sekizuka, Emina Nai, Tomohiro Yoshida, Shota Endo, Emi Hamajima, Satoka Akiyama, Yoji Ikuta, Natsuko Obana, Takahiro Kawaguchi, Kenta Hayashi, Masahiro Noda, Tomoko Sumita, Masayuki Kokaji, Tatsuo Katori, Masanori Hashino, Kunihiro Oba, Makoto Kuroda
Wichtige Hinweise

Electronic supplementary material

The online version of this article (10.​1186/​s12879-017-2870-2) contains supplementary material, which is available to authorized users.

Abstract

Background

Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen that causes a wide spectrum of clinical manifestations. Although invasive GAS (iGAS) infections are relatively uncommon, emm3/ST15 GAS is a highly virulent, invasive, and pathogenic strain. Global molecular epidemiology analysis has suggested that the frequency of emm3 GAS has been recently increasing.

Case presentation

A 14-year-old patient was diagnosed with streptococcal toxic shock syndrome and severe pneumonia, impaired renal function, and rhabdomyolysis. GAS was isolated from a culture of endotracheal aspirates and designated as KS030. Comparative genome analysis suggested that KS030 is classified as emm3 (emm-type) and ST15 (multilocus sequencing typing [MLST]), which is similar to iGAS isolates identified in the UK (2013) and Switzerland (2015).

Conclusions

We conclude that the global dissemination of emm3/ST15 GAS strain has the potential to cause invasive disease.
Zusatzmaterial
Additional file 1: General features of the isolate information and the genome sequences. In addition to KS030 genome sequence, all 483 available draft genome sequences related to ST15 type of Streptococcus pyogenes isolates have been retrieved from public short read archive databases, and the all those genome sequences were used for comparative genome analysis as described in the maintext. (XLSX 198 kb)
12879_2017_2870_MOESM1_ESM.xlsx
Literatur
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