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Neuroradiology
Erschienen in: Neuroradiology 12/2017

31.08.2017 | Diagnostic Neuroradiology

Structural and metabolic changes in the traumatically injured rat brain: high-resolution in vivo proton magnetic resonance spectroscopy at 7 T

verfasst von: Jing Li, Can Zhao, Jia-Sheng Rao, Fei-Xiang Yang, Zhan-Jing Wang, Jian-Feng Lei, Zhao-Yang Yang, Xiao-Guang Li

Erschienen in: Neuroradiology | Ausgabe 12/2017

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Abstract

Purpose

The understanding of microstructural and metabolic changes in the post-traumatic brain injury is the key to brain damage suppression and repair in clinics.

Methods

Ten female Wistar rats were traumatically injured in the brain CA1 region and above the cortex. Next, diffusion tensor magnetic resonance imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) were used to analyze the microstructural and metabolic changes in the brain within the following 2 weeks.

Results

Anisotropy fraction (FA) and axial diffusivity (AD) of the corpus callosum (CC) began to decrease significantly at day 1, whereas radial diffusivity (RD) significantly increased immediately after injury, reflecting the loss of white matter integrity. Compared with day 3, RD decreased significantly at day 7, implicating the angioedema reduction. In the hippocampus, FA significantly increased at day 7; the choline-containing compounds (Cho) and myo-inositol (MI) remarkably increased at day 7 compared with those at day 3, indicating the proliferation of astrocytes and radial glial cells after day 7. No significant differences between DTI and 1H MRS parameters were observed between day 1 and day 3.

Conclusion

Day 1–3 after traumatic brain injury (TBI) may serve as a relatively appropriate time window for treatment planning and the following nerve repair.
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Metadaten
Titel
Structural and metabolic changes in the traumatically injured rat brain: high-resolution in vivo proton magnetic resonance spectroscopy at 7 T
verfasst von
Jing Li
Can Zhao
Jia-Sheng Rao
Fei-Xiang Yang
Zhan-Jing Wang
Jian-Feng Lei
Zhao-Yang Yang
Xiao-Guang Li
Publikationsdatum
31.08.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 12/2017
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-017-1915-y

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