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Erschienen in: Die Radiologie 2/2023

19.04.2023 | Original articles

Study on diagnosis of thyroid nodules based on convolutional neural network

verfasst von: AiTao Yin, YongPing Lu, Fei Xu, YiFan Zhao, Yue Sun, Miao Huang, XiangBi Li

Erschienen in: Die Radiologie | Sonderheft 2/2023

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Abstract

Objective

An artificial intelligence (AI) algorithm based on convolutional neural networks was used in ultrasound diagnosis in order to evaluate its performance in judging the nature of thyroid nodules and nodule classification.

Methods

A total of 105 patients with thyroid nodules confirmed by surgery or biopsy were retrospectively analyzed. The properties, characteristics, and classification of thyroid nodules were evaluated by sonographers and by AI to obtain combined diagnoses. Receiver operating characteristic curves were generated to evaluate the performance of AI, the sonographer, and their combined effort in diagnosing the nature of thyroid nodules and classifying their characteristics. In the diagnosis of thyroid nodules with solid components, hypoechoic appearance, indistinct borders, Anteroposterior/transverse diameter ratio > 1(A/T > 1), and calcification performed by sonographers and by AI, the properties exhibited statistically significant differences.

Results

Sonographers had a sensitivity of 80.7%, specificity of 73.7%, accuracy of 79.0%, and area under the curve (AUC) of 0.751 in the diagnosis of benign and malignant thyroid nodules. AI had a sensitivity of 84.5%, specificity of 81.0%, accuracy of 84.7%, and AUC of 0.803. The combined AI and sonographer diagnosis had a sensitivity of 92.1%, specificity of 86.3%, accuracy of 91.7%, and AUC of 0.910.

Conclusion

The efficacy of a combined diagnosis for benign and malignant thyroid nodules is higher than that of an AI-based diagnosis alone or a sonographer-based diagnosis alone. The combined diagnosis can reduce unnecessary fine-needle aspiration biopsy procedures and better evaluate the necessity of surgery in clinical practice.
Literatur
1.
Zurück zum Zitat Kim TY, Shong YK (2017) Active surveillance of papillary thyroid microcarcinoma: a mini-review from Korea. Endocrinol Metab 32(4):399–406CrossRef Kim TY, Shong YK (2017) Active surveillance of papillary thyroid microcarcinoma: a mini-review from Korea. Endocrinol Metab 32(4):399–406CrossRef
2.
Zurück zum Zitat Zahir ST, Vakili M, Ghaneei A et al (2016) Ultrasound assistance in differentiating malignant thyroid nodules from benign ones. J Ayub Med Coll Abbottabad 28(4):644–649PubMed Zahir ST, Vakili M, Ghaneei A et al (2016) Ultrasound assistance in differentiating malignant thyroid nodules from benign ones. J Ayub Med Coll Abbottabad 28(4):644–649PubMed
3.
Zurück zum Zitat Zhang Y, Zhou P, Tian SM et al (2017) Usefulness of combined use of contrast-enhanced ultrasound and TI-RADS classification for the differe ntiation of benign from malignant lesions of thyroid nodules. Eur Radiol 27(4):1527–1536CrossRefPubMed Zhang Y, Zhou P, Tian SM et al (2017) Usefulness of combined use of contrast-enhanced ultrasound and TI-RADS classification for the differe ntiation of benign from malignant lesions of thyroid nodules. Eur Radiol 27(4):1527–1536CrossRefPubMed
4.
Zurück zum Zitat Mciver B, Hay ID, Giuffrida DF et al (2001) Anaplastic thyroid carcinoma: a 50-year experience at a single institution. Surgery 130(6):1028–1034CrossRefPubMed Mciver B, Hay ID, Giuffrida DF et al (2001) Anaplastic thyroid carcinoma: a 50-year experience at a single institution. Surgery 130(6):1028–1034CrossRefPubMed
5.
Zurück zum Zitat Liang XW, Cai YY, Yu JS et al (2019) Update on thyroid ultrasound: a narrative review from diagnostic criteria to artificial intelligence techniques. Chin Med J 132(16):1974–1982CrossRefPubMedPubMedCentral Liang XW, Cai YY, Yu JS et al (2019) Update on thyroid ultrasound: a narrative review from diagnostic criteria to artificial intelligence techniques. Chin Med J 132(16):1974–1982CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Tessler FN, Middleton WD, Grant EG et al (2017) ACR Thyroid Imaging, Reporting and Data System (TI-RADS): white paper of the ACR TI-RADS committee. J Am Coll Radiol 14(5):587–595CrossRefPubMed Tessler FN, Middleton WD, Grant EG et al (2017) ACR Thyroid Imaging, Reporting and Data System (TI-RADS): white paper of the ACR TI-RADS committee. J Am Coll Radiol 14(5):587–595CrossRefPubMed
7.
Zurück zum Zitat Kermany DS, Goldbaum M, Cai W et al (2018) Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell 172(5):1122–1131.e9CrossRefPubMed Kermany DS, Goldbaum M, Cai W et al (2018) Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell 172(5):1122–1131.e9CrossRefPubMed
8.
Zurück zum Zitat Li X, Zhang S, Zhang Q et al (2019) Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic ima ges: a retrospective, multicohort, diagnostic study. Lancet Oncol 20(2):193–201CrossRefPubMed Li X, Zhang S, Zhang Q et al (2019) Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic ima ges: a retrospective, multicohort, diagnostic study. Lancet Oncol 20(2):193–201CrossRefPubMed
9.
Zurück zum Zitat Song W, Li S, Liu J et al (2019) Multitask cascade convolution neural networks for automatic thyroid nodule detection and recognition. IEEE J Biomed Health Inform 23(3):1215–1224CrossRefPubMed Song W, Li S, Liu J et al (2019) Multitask cascade convolution neural networks for automatic thyroid nodule detection and recognition. IEEE J Biomed Health Inform 23(3):1215–1224CrossRefPubMed
10.
Zurück zum Zitat Choi YJ, Baek JH, Park HS et al (2017) A computer-aided diagnosis system using artificial intelligence for the diagnosis and characterization of thyroid nodules on ultrasound: initial clinical assessment. Thyroid 27(4):546–552CrossRefPubMed Choi YJ, Baek JH, Park HS et al (2017) A computer-aided diagnosis system using artificial intelligence for the diagnosis and characterization of thyroid nodules on ultrasound: initial clinical assessment. Thyroid 27(4):546–552CrossRefPubMed
11.
Zurück zum Zitat Wang S, Xu J, Tahmasebi A et al (2020) Incorporation of a machine learning algorithm with object detection within the thyroid imaging reporting and data system improves the diagnosis of genetic risk. Front Oncol 10:591846CrossRefPubMedPubMedCentral Wang S, Xu J, Tahmasebi A et al (2020) Incorporation of a machine learning algorithm with object detection within the thyroid imaging reporting and data system improves the diagnosis of genetic risk. Front Oncol 10:591846CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Thomas J, Haertling T (2020) AIBx, Artificial Intelligence model to risk stratify thyroid nodules. Thyroid 30(6):878–884CrossRefPubMed Thomas J, Haertling T (2020) AIBx, Artificial Intelligence model to risk stratify thyroid nodules. Thyroid 30(6):878–884CrossRefPubMed
13.
Zurück zum Zitat Wei X, Zhu J, Zhang H et al (2020) Visual interpretability in computer-assisted diagnosis of thyroid nodules using ultrasound images. Med Sci Monit 26:e927007CrossRefPubMedPubMedCentral Wei X, Zhu J, Zhang H et al (2020) Visual interpretability in computer-assisted diagnosis of thyroid nodules using ultrasound images. Med Sci Monit 26:e927007CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Wang J, Jiang J, Zhang D et al (2022) An integrated AI model to improve diagnostic accuracy of ultrasound and output known risk features in suspicious thyroid nodules. Eur Radiol 32(3):2120–2129CrossRefPubMed Wang J, Jiang J, Zhang D et al (2022) An integrated AI model to improve diagnostic accuracy of ultrasound and output known risk features in suspicious thyroid nodules. Eur Radiol 32(3):2120–2129CrossRefPubMed
15.
Zurück zum Zitat Zhang B, Tian J, Pei S et al (2019) Machine learning-assisted system for thyroid nodule diagnosis. Thyroid 29(6):858–867CrossRefPubMed Zhang B, Tian J, Pei S et al (2019) Machine learning-assisted system for thyroid nodule diagnosis. Thyroid 29(6):858–867CrossRefPubMed
16.
Zurück zum Zitat Wei X, Gao M, Yu R et al (2020) Ensemble deep learning model for multicenter classification of thyroid nodules on ultrasound images. Med Sci Monit 26:e926096CrossRefPubMedPubMedCentral Wei X, Gao M, Yu R et al (2020) Ensemble deep learning model for multicenter classification of thyroid nodules on ultrasound images. Med Sci Monit 26:e926096CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Chambara N, Ying M (2019) The diagnostic efficiency of ultrasound computer-aided diagnosis in differentiating thyroid nodules: a systematic review and narrative synthesis. Cancers 11(11):1759CrossRefPubMedPubMedCentral Chambara N, Ying M (2019) The diagnostic efficiency of ultrasound computer-aided diagnosis in differentiating thyroid nodules: a systematic review and narrative synthesis. Cancers 11(11):1759CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Zhang T, Li F, Mu J, Liu J, al Zhet (2017) Multivariate evaluation of Thyroid Imaging Reporting and Data System (TI-RADS) in diagnosis malignant thyroid nodule: application to PCA and PLS-DA analysis. Int J Clin Oncol 22(3):448–454CrossRefPubMed Zhang T, Li F, Mu J, Liu J, al Zhet (2017) Multivariate evaluation of Thyroid Imaging Reporting and Data System (TI-RADS) in diagnosis malignant thyroid nodule: application to PCA and PLS-DA analysis. Int J Clin Oncol 22(3):448–454CrossRefPubMed
19.
Zurück zum Zitat Gong T, Wang J (2012) The analysis of the calcification in differentiating malignant thyroid neoplasm and the molecular me chanisms for the formation of the calcification. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26(16):763–766 Gong T, Wang J (2012) The analysis of the calcification in differentiating malignant thyroid neoplasm and the molecular me chanisms for the formation of the calcification. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26(16):763–766
20.
Zurück zum Zitat Frates MC, Benson CB, Charboneau JW et al (2006) Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus confere nce statement. Ultrasound Q 22(4):231–238 (discussion 9–40)CrossRefPubMed Frates MC, Benson CB, Charboneau JW et al (2006) Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus confere nce statement. Ultrasound Q 22(4):231–238 (discussion 9–40)CrossRefPubMed
21.
Zurück zum Zitat Su JJ, Hui LZ, Xi CJ, Su GQ (2015) Correlation analysis of ultrasonic characteristics, pathological type, and molecular markers of thyroid nodules. Genet Mol Res 14(1):9–20CrossRefPubMed Su JJ, Hui LZ, Xi CJ, Su GQ (2015) Correlation analysis of ultrasonic characteristics, pathological type, and molecular markers of thyroid nodules. Genet Mol Res 14(1):9–20CrossRefPubMed
22.
Zurück zum Zitat Moon HJ, Kwak JY, Kim EK, Kim MJ (2011) A taller-than-wide shape in thyroid nodules in transverse and longitudinal ultrasonographic planes and the prediction of malignancy. Thyroid 21(11):1249–1253CrossRefPubMed Moon HJ, Kwak JY, Kim EK, Kim MJ (2011) A taller-than-wide shape in thyroid nodules in transverse and longitudinal ultrasonographic planes and the prediction of malignancy. Thyroid 21(11):1249–1253CrossRefPubMed
23.
Zurück zum Zitat Zhang S, Zhao J, Xin XJ et al (2013) Diagnostic value of thyroid microcarcinoma with a taller-than-wide shape in thyroid nodules. Zhonghua Yi Xue Za Zhi 93(40):3223–3225PubMed Zhang S, Zhao J, Xin XJ et al (2013) Diagnostic value of thyroid microcarcinoma with a taller-than-wide shape in thyroid nodules. Zhonghua Yi Xue Za Zhi 93(40):3223–3225PubMed
24.
Zurück zum Zitat Desser TS, Kamaya A (2008) Ultrasound of thyroid nodules. Neuroimaging Clin N Am 18(3):463–478CrossRefPubMed Desser TS, Kamaya A (2008) Ultrasound of thyroid nodules. Neuroimaging Clin N Am 18(3):463–478CrossRefPubMed
25.
Zurück zum Zitat Yao S, Yan J, Wu M et al (2020) Texture synthesis based thyroid nodule detection from medical ultrasound images: interpreting and sup pressing the adversarial effect of in-place manual annotation. Front Bioeng Biotechnol 8:599CrossRefPubMedPubMedCentral Yao S, Yan J, Wu M et al (2020) Texture synthesis based thyroid nodule detection from medical ultrasound images: interpreting and sup pressing the adversarial effect of in-place manual annotation. Front Bioeng Biotechnol 8:599CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Akkus Z, Cai J, Boonrod A et al (2019) A survey of deep-learning applications in ultrasound: artificial intelligence-powered ultrasound for improving clinical workflow. J Am Coll Radiol 16(9 Pt B):1318–1328CrossRefPubMed Akkus Z, Cai J, Boonrod A et al (2019) A survey of deep-learning applications in ultrasound: artificial intelligence-powered ultrasound for improving clinical workflow. J Am Coll Radiol 16(9 Pt B):1318–1328CrossRefPubMed
Metadaten
Titel
Study on diagnosis of thyroid nodules based on convolutional neural network
verfasst von
AiTao Yin
YongPing Lu
Fei Xu
YiFan Zhao
Yue Sun
Miao Huang
XiangBi Li
Publikationsdatum
19.04.2023
Verlag
Springer Medizin
Erschienen in
Die Radiologie / Ausgabe Sonderheft 2/2023
Print ISSN: 2731-7048
Elektronische ISSN: 2731-7056
DOI
https://doi.org/10.1007/s00117-023-01137-4

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