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14.11.2018 | Sleep Breathing Physiology and Disorders • Short Communication

Successful upper airway stimulation therapy in an adult Down syndrome patient with severe obstructive sleep apnea

verfasst von: Eli Van de Perck, Jolien Beyers, Marijke Dieltjens, Sara Op de Beeck, Johan Verbraecken, Paul Van de Heyning, An Boudewyns, Olivier M. Vanderveken

Erschienen in: Sleep and Breathing | Ausgabe 3/2019

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Abstract

Purpose

The aim of this study was to report on the successful application of upper airway stimulation (UAS) therapy in an adult Down syndrome (DS) patient with severe obstructive sleep apnea (OSA) and continuous positive airway pressure (CPAP) intolerance.

Methods

Baseline polysomnography (PSG) in a 23-year-old male OSA patient (body mass index (BMI) 24.4 kg/m²) revealed an apnea/hypopnea index (AHI) of 61.5 events/h and oxygen desaturation index (ODI) of 39.7 events/h. Based on the clinical examination, PSG and drug-induced sleep endoscopy, the patient fulfilled the formal inclusion criteria for UAS therapy: AHI between 15 and 65 events/h, BMI < 32 kg/m², and no complete concentric collapse at the level of the velopharynx.

Results

Implantation of the hypoglossal nerve stimulator in the adult patient with DS resulted in a substantial subjective as well as objective improvement of OSA (63 to 81% decrease in AHI and 77% decrease in ODI), translating into an overall satisfactory outcome.

Conclusion

Research on the long-term effectiveness of UAS therapy in a larger group of patients with DS is needed. However, based on the available literature and our presented case, respiration-synchronized electrostimulation of the hypoglossal nerve using UAS therapy may have a potential value in well-selected OSA patients with DS who are non-compliant to CPAP therapy.

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Titel: Successful upper airway stimulation therapy in an adult Down syndrome patient with severe obstructive sleep apnea
verfasst von: Eli Van de Perck
Jolien Beyers
Marijke Dieltjens
Sara Op de Beeck
Johan Verbraecken
Paul Van de Heyning
An Boudewyns
Olivier M. Vanderveken
Publikationsdatum: 14.11.2018
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 3/2019
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1752-1

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Successful upper airway stimulation therapy in an adult Down syndrome patient with severe obstructive sleep apnea