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Erschienen in: Journal of Medical Systems 3/2020

01.03.2020 | Patient Facing Systems

Survivability Prognosis for Lung Cancer Patients at Different Severity Stages by a Risk Factor-Based Bayesian Network Modeling

verfasst von: Kung-Jeng Wang, Jyun-Lin Chen, Kun-Huang Chen, Kung-Min Wang

Erschienen in: Journal of Medical Systems | Ausgabe 3/2020

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Abstract

Lung cancer is a major reason of mortalities. Estimating the survivability for this disease has become a key issue to families, hospitals, and countries. A conditional Gaussian Bayesian network model was presented in this study. This model considered 15 risk factors to predict the survivability of a lung cancer patient at 4 severity stages. We surveyed 1075 patients. The presented model is constructed by using the demographic, diagnosed-based, and prior-utilization variables. The proposed model for the survivability prognosis at different four stages performed R2 of 93.57%, 86.83%, 67.22%, and 52.94%, respectively. The model predicted the lung cancer survivability with high accuracy compared with the reported models. Our model also shows that it reached the ceiling of an ideal Bayesian network.
Literatur
1.
Zurück zum Zitat Health Promotion Administration, Ministry of Health and Welfare. (2014). 2014 health promotion administration annual report. Taipei: Health Promotion Administration, Ministry of Health and Welfare. Health Promotion Administration, Ministry of Health and Welfare. (2014). 2014 health promotion administration annual report. Taipei: Health Promotion Administration, Ministry of Health and Welfare.
2.
Zurück zum Zitat Lang, H.-C., and Wu, S.-L., Lifetime costs of the top five cancers in Taiwan. The European Journal of Health Economics 13(3):347–353, 2012.PubMedCrossRef Lang, H.-C., and Wu, S.-L., Lifetime costs of the top five cancers in Taiwan. The European Journal of Health Economics 13(3):347–353, 2012.PubMedCrossRef
3.
Zurück zum Zitat Ministry of Health and Welfare. (2014, 12). National Health Insurance Annual Report. Taipei: Ministry of Health and Welfare. Ministry of Health and Welfare. (2014, 12). National Health Insurance Annual Report. Taipei: Ministry of Health and Welfare.
4.
Zurück zum Zitat Chang, R.-E., and Chiang, T.-L., Risk adjustment: A key to efficiency and equity in the health insurance market. Chinese Journal of Public Health 17(5):373–380, 1998. Chang, R.-E., and Chiang, T.-L., Risk adjustment: A key to efficiency and equity in the health insurance market. Chinese Journal of Public Health 17(5):373–380, 1998.
5.
Zurück zum Zitat Chang, R.-E., Lin, W., Hsieh, C.-J., and Chiang, T.-L., Healthcare utilization patterns and risk adjustment under Taiwan's National Health Insurance System. Journal of the Formosan Medical Associatio 101(1):52–59, 2002. Chang, R.-E., Lin, W., Hsieh, C.-J., and Chiang, T.-L., Healthcare utilization patterns and risk adjustment under Taiwan's National Health Insurance System. Journal of the Formosan Medical Associatio 101(1):52–59, 2002.
6.
Zurück zum Zitat Wang, K. J., Chen, K. H., Huang, S. H., and Teng, N. C., A prognosis tool based on fuzzy anthropometric and questionnaire data for obstructive sleep apnea severity. Journal of Medical Systems 40(4):110, 2016.PubMedCrossRef Wang, K. J., Chen, K. H., Huang, S. H., and Teng, N. C., A prognosis tool based on fuzzy anthropometric and questionnaire data for obstructive sleep apnea severity. Journal of Medical Systems 40(4):110, 2016.PubMedCrossRef
7.
Zurück zum Zitat Chang, R.-E., and Lai, C.-L., Risk adjuster: The basis for capitation payment. Taiwan Journal of Public Health 23(2):91–99, 2004. Chang, R.-E., and Lai, C.-L., Risk adjuster: The basis for capitation payment. Taiwan Journal of Public Health 23(2):91–99, 2004.
8.
Zurück zum Zitat Rice, N., and Smith, P. C., Capitation and risk adjustment in health care financing: An international Progress report. The Milbank Quarterly 79(1):81–113, 2001.PubMedPubMedCentralCrossRef Rice, N., and Smith, P. C., Capitation and risk adjustment in health care financing: An international Progress report. The Milbank Quarterly 79(1):81–113, 2001.PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat van de Ven, W. P. M. M., and Ellis, R. P., Risk adjustment in competitive health plan markets. In: Culyer, A. J. (Ed.), Handbool of health economics. Amsterdam: Elsevier Science, 2000, 755–845. van de Ven, W. P. M. M., and Ellis, R. P., Risk adjustment in competitive health plan markets. In: Culyer, A. J. (Ed.), Handbool of health economics. Amsterdam: Elsevier Science, 2000, 755–845.
10.
Zurück zum Zitat Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). (2014). SEER Cancer Statistics Review, 1975–2011. Retrieved from National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site. Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). (2014). SEER Cancer Statistics Review, 1975–2011. Retrieved from National Cancer Institute. Bethesda, MD, http://​seer.​cancer.​gov/​csr/​1975_​2011/​, based on November 2013 SEER data submission, posted to the SEER web site.
11.
Zurück zum Zitat Ko, Y.-C., Lee, C.-H., Chen, M.-J., Huang, C.-C., Chang, W.-Y., Lin, H.-J., Wang, H.-Z., and Chang, P.-Y., Risk factors for primary lung cancer among non-smoking women in Taiwan. International Journal of Epidemiology 26(1):24–31, 1997.PubMedCrossRef Ko, Y.-C., Lee, C.-H., Chen, M.-J., Huang, C.-C., Chang, W.-Y., Lin, H.-J., Wang, H.-Z., and Chang, P.-Y., Risk factors for primary lung cancer among non-smoking women in Taiwan. International Journal of Epidemiology 26(1):24–31, 1997.PubMedCrossRef
12.
Zurück zum Zitat Samet, J. M., Tang, E. A., Boffetta, P., Hannan, L. M., Marston, S. O., Thun, M. J., and Ruding, C. M., Lung cancer in never smokers: Clinical epidemiology and environmental risk factors. Clinical Cancer Research 15(18):5626–5645, 2009.PubMedPubMedCentralCrossRef Samet, J. M., Tang, E. A., Boffetta, P., Hannan, L. M., Marston, S. O., Thun, M. J., and Ruding, C. M., Lung cancer in never smokers: Clinical epidemiology and environmental risk factors. Clinical Cancer Research 15(18):5626–5645, 2009.PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Wang, B.-Y., Huang, J.-Y., Cheng, C.-Y., Lin, C.-H., Ko, J.-L., and Liaw, Y.-P., Lung Cancer and prognosis in Taiwan: A population-based Cancer registry. Journal of Thoracic Oncology 8(9):1128–1135, 2013.PubMedCrossRef Wang, B.-Y., Huang, J.-Y., Cheng, C.-Y., Lin, C.-H., Ko, J.-L., and Liaw, Y.-P., Lung Cancer and prognosis in Taiwan: A population-based Cancer registry. Journal of Thoracic Oncology 8(9):1128–1135, 2013.PubMedCrossRef
14.
Zurück zum Zitat Jensen, F. V., Introduction to Bayeisan network. Berlin: Springer, 1996. Jensen, F. V., Introduction to Bayeisan network. Berlin: Springer, 1996.
15.
Zurück zum Zitat Uusitalo, L., Advantages and challenges of Bayesian networks in environmental Modelling. Ecological Modeling 203:312–318, 2007.CrossRef Uusitalo, L., Advantages and challenges of Bayesian networks in environmental Modelling. Ecological Modeling 203:312–318, 2007.CrossRef
16.
Zurück zum Zitat Lucas, P. J., van der Gaaq, L. C., and Abu-Hanna, A., Bayesian networks in biomedicine and health-care. Artificial Intelligence in Medicine 30(3):201–214, 2004.PubMedCrossRef Lucas, P. J., van der Gaaq, L. C., and Abu-Hanna, A., Bayesian networks in biomedicine and health-care. Artificial Intelligence in Medicine 30(3):201–214, 2004.PubMedCrossRef
17.
Zurück zum Zitat Kaviarasi, R., Accuracy enhanced lung Cancer prognosis for improving patient survivability using proposed Gaussian classifier system. Journal of Medical Systems 43(7):201, 2019.CrossRef Kaviarasi, R., Accuracy enhanced lung Cancer prognosis for improving patient survivability using proposed Gaussian classifier system. Journal of Medical Systems 43(7):201, 2019.CrossRef
18.
Zurück zum Zitat Petousis, P., Han, S. X., Aberle, D., and Bui, A. A., Prediction of lung cancer incidence on the low-dose computed tomography arm of the National Lung Screening Trial: A dynamic Bayesian network. Artificial Intelligence in Medicine 72:42–55, 2016.PubMedPubMedCentralCrossRef Petousis, P., Han, S. X., Aberle, D., and Bui, A. A., Prediction of lung cancer incidence on the low-dose computed tomography arm of the National Lung Screening Trial: A dynamic Bayesian network. Artificial Intelligence in Medicine 72:42–55, 2016.PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Yoo, I., Alafaireet, P., Marinov, M., Pena-Hernandez, K., Gopidi, R., Chang, J. F., and Hua, L., Data mining in healthcare and biomedicine: A survey of the literature. Journal of Medical Systems 36(4):2431–2448, 2012.PubMedCrossRef Yoo, I., Alafaireet, P., Marinov, M., Pena-Hernandez, K., Gopidi, R., Chang, J. F., and Hua, L., Data mining in healthcare and biomedicine: A survey of the literature. Journal of Medical Systems 36(4):2431–2448, 2012.PubMedCrossRef
20.
Zurück zum Zitat Cobb, B. R., Rumi, R., and Salmeron, A., Bayesian network models with discrete and continuous variables. Advances in Probabilistic Graphical Models, Studies in Fuzziness and Soft Computing 214:81–102, 2007.CrossRef Cobb, B. R., Rumi, R., and Salmeron, A., Bayesian network models with discrete and continuous variables. Advances in Probabilistic Graphical Models, Studies in Fuzziness and Soft Computing 214:81–102, 2007.CrossRef
21.
Zurück zum Zitat Lauritzen, S. L., Propagation of probabilities, means, and variances in mixed graphical association models. Journal of the American Statistical Association 87(420):1098–1108, 1992.CrossRef Lauritzen, S. L., Propagation of probabilities, means, and variances in mixed graphical association models. Journal of the American Statistical Association 87(420):1098–1108, 1992.CrossRef
22.
Zurück zum Zitat Lucena-Moya, P., Brawata, R., Kath, J., Harrison, E., ElSawah, S., and Dyer, F., Discretization of continuous predictor variables in Bayesian networks: An ecological threshold approach. Environmental Modeling & Software 66:36–45, 2015.CrossRef Lucena-Moya, P., Brawata, R., Kath, J., Harrison, E., ElSawah, S., and Dyer, F., Discretization of continuous predictor variables in Bayesian networks: An ecological threshold approach. Environmental Modeling & Software 66:36–45, 2015.CrossRef
23.
Zurück zum Zitat Lauritzen, S. L., and Wermuth, N., Graphical models for associations between variables, some of which are qualitative and some quantitative. The Annals of Statistics 17(1):31–57, 1989.CrossRef Lauritzen, S. L., and Wermuth, N., Graphical models for associations between variables, some of which are qualitative and some quantitative. The Annals of Statistics 17(1):31–57, 1989.CrossRef
24.
Zurück zum Zitat Lauritzen, S. L., and Jensen, F., Stable local computation with conditional Gaussian distributions. Statistics and Computing 11:191–203, 2001.CrossRef Lauritzen, S. L., and Jensen, F., Stable local computation with conditional Gaussian distributions. Statistics and Computing 11:191–203, 2001.CrossRef
26.
Zurück zum Zitat Chen, K.-H., Wang, K. J., Adrian, A. M., Wang, K. M., and Teng, N.-C., Diagnosis of brain metastases from lung cancer using a modified electromagnetism like mechanism algorithm. Journal of Medical Systems 40(1):35, 2016.PubMedCrossRef Chen, K.-H., Wang, K. J., Adrian, A. M., Wang, K. M., and Teng, N.-C., Diagnosis of brain metastases from lung cancer using a modified electromagnetism like mechanism algorithm. Journal of Medical Systems 40(1):35, 2016.PubMedCrossRef
27.
Zurück zum Zitat Wang, K. J., Chen, J. L., and Wang, K. M., Medical expenditure estimation by Bayesian network for lung cancer patients at different severity stages. Computers in Biology and Medicine 106:97–105, 2019.PubMedCrossRef Wang, K. J., Chen, J. L., and Wang, K. M., Medical expenditure estimation by Bayesian network for lung cancer patients at different severity stages. Computers in Biology and Medicine 106:97–105, 2019.PubMedCrossRef
29.
Zurück zum Zitat Fuch, V. R., The growing demand for medical care. The New England Journal of Medicine 279:190–195, 1968.CrossRef Fuch, V. R., The growing demand for medical care. The New England Journal of Medicine 279:190–195, 1968.CrossRef
30.
Zurück zum Zitat Chang, R.-E., and Lai, C.-L., Use of diagnosis-based risk adjustment models to predict individual health care expenditure under the National Health Insurance System in Taiwan. Journal of the Formosan Medical Association 104(12):883–890, 2005.PubMed Chang, R.-E., and Lai, C.-L., Use of diagnosis-based risk adjustment models to predict individual health care expenditure under the National Health Insurance System in Taiwan. Journal of the Formosan Medical Association 104(12):883–890, 2005.PubMed
31.
Zurück zum Zitat Lin, W., Chang, R.-E., Hsieh, C.-J., Yaung, C.-L., and Chiang, T.-L., Development of a risk-adjusted capitation model based on principal inpatient diagnoses in Taiwan. Journal of the Formosan Medical Association 102(9):637–643, 2003.PubMed Lin, W., Chang, R.-E., Hsieh, C.-J., Yaung, C.-L., and Chiang, T.-L., Development of a risk-adjusted capitation model based on principal inpatient diagnoses in Taiwan. Journal of the Formosan Medical Association 102(9):637–643, 2003.PubMed
32.
Zurück zum Zitat Pannarunothai, S., and Phanthunane, P., Using utilisation data to estimate future demand for medical internists: The impact of demographic demand driver in Thailand. Studies in Health Technology and Informatics 178:169–174, 2012.PubMed Pannarunothai, S., and Phanthunane, P., Using utilisation data to estimate future demand for medical internists: The impact of demographic demand driver in Thailand. Studies in Health Technology and Informatics 178:169–174, 2012.PubMed
33.
Zurück zum Zitat Stearns, S. C., Kovar, M. G., Hayes, K., and Koch, G. G., Risk indicators for hospitalization during the last year of life. Health Services Research 31(1):49–69, 1996.PubMedPubMedCentral Stearns, S. C., Kovar, M. G., Hayes, K., and Koch, G. G., Risk indicators for hospitalization during the last year of life. Health Services Research 31(1):49–69, 1996.PubMedPubMedCentral
35.
Zurück zum Zitat American Cancer Society, Global Cancer facts and figures. 2nd edition. Atlanta: American Cancer Society, 2011. American Cancer Society, Global Cancer facts and figures. 2nd edition. Atlanta: American Cancer Society, 2011.
36.
Zurück zum Zitat Wang, K. J., Makond, B., and Wang, K.-M., Modeling and predicting the occurrence of brain metastasis from lung Cancer by Bayesian network: A case study of Taiwan. Computers in Biology and Medicine 47:147–160, 2014.PubMedCrossRef Wang, K. J., Makond, B., and Wang, K.-M., Modeling and predicting the occurrence of brain metastasis from lung Cancer by Bayesian network: A case study of Taiwan. Computers in Biology and Medicine 47:147–160, 2014.PubMedCrossRef
37.
Zurück zum Zitat Liu, C.-Y., Hung, Y.-T., Chuang, Y.-L., Chen, Y.-J., Weng, W.-S., Liu, J.-S., and Liang, K.-Y., Incorporating development stratification of Taiwan townships into sampling Design of Large Scale Health Interview Survey. Journal of Health Management 4(1):1–22, 2006. Liu, C.-Y., Hung, Y.-T., Chuang, Y.-L., Chen, Y.-J., Weng, W.-S., Liu, J.-S., and Liang, K.-Y., Incorporating development stratification of Taiwan townships into sampling Design of Large Scale Health Interview Survey. Journal of Health Management 4(1):1–22, 2006.
38.
Zurück zum Zitat Corral, J., Espinàs, J. A., Cots, F., Pareja, L., Solà, J., Font, R., and Borràs, J. M., Estimation of lung Cancer diagnosis and treatment costs based on a patient-level analysis in Catalonia (Spain). BMC Health Services Research 15(70):1–10, 2015. Corral, J., Espinàs, J. A., Cots, F., Pareja, L., Solà, J., Font, R., and Borràs, J. M., Estimation of lung Cancer diagnosis and treatment costs based on a patient-level analysis in Catalonia (Spain). BMC Health Services Research 15(70):1–10, 2015.
39.
Zurück zum Zitat Cucciare, M. A., and O’Donohue, W., Predicting future healthcare cost: How well does risk-adjustment work? Journal of Health Organization and Management 20(2):150–162, 2006.PubMedCrossRef Cucciare, M. A., and O’Donohue, W., Predicting future healthcare cost: How well does risk-adjustment work? Journal of Health Organization and Management 20(2):150–162, 2006.PubMedCrossRef
40.
Zurück zum Zitat Cartwright, N., What are randomised controlled trials good for? Philosophical studies 147(1):59, 2010.CrossRef Cartwright, N., What are randomised controlled trials good for? Philosophical studies 147(1):59, 2010.CrossRef
41.
Zurück zum Zitat Kovesdy, C. P., and Kalantar-Zadeh, K., Observational studies versus randomized controlled trials: Avenues to causal inference in nephrology. Advances in Chronic kKidney Disease 19(1):11–18, 2012.CrossRef Kovesdy, C. P., and Kalantar-Zadeh, K., Observational studies versus randomized controlled trials: Avenues to causal inference in nephrology. Advances in Chronic kKidney Disease 19(1):11–18, 2012.CrossRef
42.
Zurück zum Zitat Bøttcher, S. G., & Dethlefsen, C. (2003). Deal: A package for learning Bayesian networks. Journal of Statistical Software, 8(20), pp. 1-40. Retrieved from Deal: A package for learning bayesian networks. Bøttcher, S. G., & Dethlefsen, C. (2003). Deal: A package for learning Bayesian networks. Journal of Statistical Software, 8(20), pp. 1-40. Retrieved from Deal: A package for learning bayesian networks.
43.
Zurück zum Zitat Scutari, M., Learning Bayesian networks with the bnlearn R package. Journal of Statistical Software 35(3):1–22, 2010.CrossRef Scutari, M., Learning Bayesian networks with the bnlearn R package. Journal of Statistical Software 35(3):1–22, 2010.CrossRef
45.
Zurück zum Zitat Chang, H.-Y., Evaluation of alternative diagnosis-based risk adjustment models and morbidity trajectories for application in Taiwan. Baltimore: The Johns Hopkins University, 2009. Chang, H.-Y., Evaluation of alternative diagnosis-based risk adjustment models and morbidity trajectories for application in Taiwan. Baltimore: The Johns Hopkins University, 2009.
Metadaten
Titel
Survivability Prognosis for Lung Cancer Patients at Different Severity Stages by a Risk Factor-Based Bayesian Network Modeling
verfasst von
Kung-Jeng Wang
Jyun-Lin Chen
Kun-Huang Chen
Kung-Min Wang
Publikationsdatum
01.03.2020
Verlag
Springer US
Erschienen in
Journal of Medical Systems / Ausgabe 3/2020
Print ISSN: 0148-5598
Elektronische ISSN: 1573-689X
DOI
https://doi.org/10.1007/s10916-020-1537-5

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