Introduction
Methods
Search strategy and study selection
Data collection
Statistical analyses
Results
Search results
Study | Design | Diagnosis: new/or recurrent | Grade 3, 4, or both | CW treatment regimen | Other treatment | CW no. of patients | 1-year OS (%) | 2-year OS (%) |
---|---|---|---|---|---|---|---|---|
Affronti et al. [18] | RCS, cohort, SC | New | 4 | Surgery + CW + RT + TMZ + multiagent rotational chemo | Surgery + RT + TMZ + multiagent rotational chemo | 36 | 81 | 47 |
Anderson and Thomson (abstr) [19] | RCS, SC | Both | Both | Surgery + CW | n/a | 11 | Not reported | Not reported |
Aoki et al. [20] | Phase 1/2 | Both | Both | Surgery + CW + RT + TMZ ± INF-B | n/a | New diagnosis, grade 3 or 4: 16; new diagnosis: grade 4 only: 9; recurrent, grade 3 or 4: 8; recurrent, grade 4 only: 4 | New diagnosis, grade 3 or 4: 100; new diagnosis, grade 4 only: not reported; recurrent, grade 3 or 4: 62.5; recurrent, grade 4 only: 50 | New diagnosis, grade 3 or 4: 68.8; new diagnosis, grade 4 only: 44.4; recurrent, grade 3 or 4: 25; recurrent, grade 4 only: not reported |
Attenello et al. [21] | RCS, cohort, SC | Both | Both | Surgery + CW | Surgery | Primary resection: 166; revision resection: 122; grade 3: 250; grade 4: 38 | Primary, grade 3: 78; primary, grade 4: 57; revision, grade 3: 68; revision, grade 4: 47 | Primary, grade 3: 66; primary, grade 4: 20; revision, grade 3: 47; revision, grade 4: 13 |
Barr and Grundy [22] | RCS, SC | Both | Both | Surgery + CW ± RT ± TMZ | n/a | Primary resection: 59; revision resection: 5 | Primary: 61; revision: not reported | Primary: 20; revision: not reported |
Bock et al. [23] | RCS, MC | New | 4 | Surgery + CW + RT + TMZ | n/a | 44 | 58 | 13 |
Brem et al. [24] | Phase 1/2 | Recurrent | Both | Surgery + CW | n/a | 21 | 38 | n/a |
Brem et al. [13] | RCT, MC | Recurrent | Both | Surgery + CW ± chemo | Surgery + Placebo ± chemo | 110 | 24 | 11 |
Catalán-Uribarrena et al. [25] | Prospective cohort | New | Both | Surgery + CW + RT | Surgery + RT ± TMZ | 55 | 52 | 11 |
Chaichana et al. [26] | RCCS | New | 4 | Surgery + CW ± RT ± TMZ | Surgery ± RT ± TMZ | 45 | 33 | 9 |
Damilakis 2011 (abstr) [27] | RCS, SC | New | 4 | Surgery + CW + RT | n/a | 22 | Not reported | Not reported |
Darakchiev et al. [28] | Phase 1/2 | Recurrent | 4 | Surgery + CW + I-125 (± RT ± chemo) | n/a | 34 | 66 | 23 |
De Bonis et al. [29] | RCS, SC | Both | 4 | Surgery + CW ± RT ± TMZ | Surgery ± RT ± TMZ | New: 19 Recurrent: 28 | Not reported | Not reported |
Della Puppa et al. [30] | RCS, SC | Both | Both | Surgery + CW + chemo ± RT | n/a | 36 | Not reported | Not reported |
Della Puppa et al. [31] | RCS, SC | Both | Both | Surgery + CW + chemo ± RT | n/a | 55 | Not reported | Not reported |
De’Santi et al. [32] | Case series, SC | Both | 4 | Surgery + 5-ALA + CW + RT + TMZ | n/a | 10 | Not reported | Not reported |
Desjardins et al. (abstr) [33] | Phase 2 | New | 4 | Surgery + CW + RT + TMZ + Bev | n/a | 33 | Not reported | Not reported |
Dörner et al. [34] | RCS, SC | Both | Both | Surgery + CW | n/a | 88 | Not reported | Not reported |
Duntze et al. [35] | Prospective cohort | New | Both | Surgery + CW + RT + TMZ | n/a | 92 | 70.3 | 37 |
Giese et al. [36] | Phase 3 RCT (subgroup analysis) | New | 4 | Surgery + CW + RT | Surgery + placebo + RT | 11 | Not reported | Not reported |
Gutenberg et al. [37] | RCS | Both | 4 | Surgery + CW ± RT ± TMZ | n/a | New diagnosis, without TMZ: 13; new diagnosis, with TMZ: 17; recurrent, unmethylated: 11; recurrent, methylated: 6 | Without TMZ: 78; with TMZ: 100; recurrent: Not reported | Without TMZ: 0; with TMZ: 38; recurrent: not reported |
Ho et al. (abstr) [38] | RCS, SC | Not specified | Not stated | Surgery + CW ± RT ± TMZ | Surgery ± RT ± TMZ | 26 | Not reported | Not reported |
Hoffmann (abstr) [39] | RCS, SC | Both | Both | Surgery + CW ± RT ± TMZ | Not specified | 34 | Not reported | Not reported |
Kleinberg 2004 [40] | RCS, SC | New | Both | Surgery + CW +RT | n/a | 39 | Not reported | Not reported |
Ko et al. [41] | RCS | Recurrent | 4 | Surgery + CW ± I-125 | n/a | CW +I-125: 17; CW alone: 7 | CW + I-125: 41; CW alone: 16 | CW + I-125: 22; CW alone: 0 |
Krex et al. (abstr) [42] | RCS, SC | Recurrent | 4 | Surgery + CW + RT + TMZ | n/a | 60 | Not reported | Not reported |
Kunwar et al. [43] | Phase 3 RCT | Recurrent | 4 | Surgery + CW | Surgery + CB | 93 | 38 | 13 |
Lechapt-Zalcman et al. [44] | Prospective observational MC | New | 4 | Surgery + CW + RT + TMZ | n/a | 111 | 71.7 | 34.2 |
Lemcke et al. [45] | RCS | Not specified | Grade 4 | Surgery + CW | Surgery alone | 30 | Not reported | Not reported |
Lopez et al. (abstr) [46] | RCS, SC | Recurrent | 4 | Surgery + CW ± TMZ | n/a | 14 | 64.3 | 50 |
McGirt et al. [47] | RCS, cohort, SC | New | 4 | Surgery + CW + RT ± TMZ | Surgery + RT + TMZ | With TMZ: 30; no TMZ: 78 | With TMZ: 92; no TMZ: 57 | With TMZ: 39; no TMZ: 18 |
McGovern et al. [48] | RCS, SC | Recurrent | Both | Surgery + CW | n/a | 33 | Not reported | Not reported |
Menei et al. [49] | RCS, MC | Both | Both | Surgery + CW ± RT ± TMZ/chemo | n/a | New: 83; recurrent: 80 | Not reported | Not reported |
Metellus et al. [6] | Prospective cohort | Recurrent | 4 | Surgery + CW | n/a | 22 | 36.4 | Not reported |
Metellus et al. (abstr) [50] | Prospective cohort | New | 4 | Surgery + CW + RT | n/a | 29 | 51 | Not reported |
Miglierini et al. [51] | RCS, SC | New | 4 | Surgery + CW + RT + TMZ | n/a | 24 | 78 | 24 |
Noël et al. [52] | RCS, SC | New | Both | Surgery + CW + RT + TMZ | Surgery + RT + TMZ | Grade 3 or 4: 28; grade 4 only: 20 | Grade 3 or 4: 78.6; grade 4 only: 75 | Grade 3 or 4: 40.9; grade 4 only: 38.9 |
Pan et al. [53] | RCS, SC | New | 4 | Surgery + CW + RT + TMZ | n/a | 21 | 75 | 39 |
Perez Gomez et al. [54] | RCS | New | Both | Surgery + CW + RT + TMZ | n/a | 49 | 60.5 | 21.3 |
Qadri et al. (abstr) [55] | RCS, SC | Recurrent | Both | Surgery + CW | n/a | Grade 3 o4 4: 20; grade 4 only: 15 | Grade 3 or 4: not stated; grade 4 only: 41 | Not reported |
Qadri et al. (abstr) [56] | RCS, SC | Recurrent | 4 | Surgery + CW | n/a | 14 | Not reported | Not reported |
Quinn 2009 [57] | Phase 2, OL, SC | Recurrent | 4 | Surgery + CW + O-6-BG | n/a | 52 | 47 | 10 |
Quiros [58] | Retrospective cohort | New | Both | Surgery + CW + RT + TMZ | Surgery + RT + TMZ | 35 | Not reported | Not reported |
Ranjan et al. [59] | Phase 2 | New | 4 | Surgery + CW + RT + TMZ + Bev | n/a | 41 | Not reported | Not reported |
Rezazadeh et al. [abstr] [60] | Phase 2 | New | 4 | Surgery + CW + RT + TMZ + Bev | n/a | 10 | Not reported | Not reported |
Ryken (abstr) [61] | Prospective cohort | New | 4 | Surgery + CW + RT + TMZ | n/a | 21 | Not reported | Not reported |
Salmaggi et al. [62] | Phase 2 | New | 4 | Surgery + CW + RT + TMZ | n/a | 35 | 85 | 30 |
Salvati et al. [63] | RCS, SC | New | 4 | Surgery + CW + RT + TMZ | n/a | 32 | 100 | Not reported |
Samis Zella et al. [64] | RCS | Recurrent | 4 | Surgery + CW ± TMZ ± other chemo | Surgery ± TMZ ± other chemo | 63 | Not reported | Not reported |
Satilmis et al. (abstr) [65] | RCS, SC | Recurrent | 4 | Surgery + CW | n/a | 71 | Not reported | Not reported |
Shah et al. [66] | RCS | Both | Both | Surgery + CW ± RT ± TMZ | n/a | 177 patients (181 surgeries) | Not reported | Not reported |
Silvani et al. (abstr) [67] | Phase 2 | New | 4 | Surgery + CW + RT + TMZ | n/a | 35 | Not reported | Not reported |
Smith et al. [68] | Phase 1/2 prospective, SC | New | 4 | Surgery + CW + GKS + RT | n/a | 27 | 51 | 22 |
Subach et al. [69] | RCS matched cohort, SC | Recurrent | 4 | Surgery + CW | Surgery | 17 | 0 | Not reported |
Sumrall et al. (abstr) [70] | Phase 1/2 | New | Both | Surgery + CW + RT + TMZ | n/a | Grade 4 only: 43 | 74 | Not reported |
Uff et al. (abstr) [71] | RCS, SC | Recurrent | Not stated | Surgery + CW | n/a | 30 | 37 | Not reported |
Ulmer et al. [72] | RCS | Both | 4 | Surgery + CW ± RT ± TMZ | n/a | 44 | 32 | 5 |
Valtonen et al. [11] | Phase 3 RCT | New | Both | Surgery + CW + RT | Surgery + placebo + RT | Grade 3 or 4: 16; grade 4 only: 11 | Grade 3 or 4: 64; grade 4 only: 55 | Grade 3 or 4: 32; grade 4 only: 19 |
Watts et al. [73] | Prospective single-arm | New | 4 | Surgery + 5-ALA + CW + RT + TMZ | n/a | 59 | Not reported | Not reported |
Westphal et al. [12] | Phase 3 RCT | New | Both | Surgery + CW + RT | Surgery + Placebo + RT | Grade 3 or 4: 120; grade 4 only: 101 | Grade 3 or 4: 59.2; grade 4 only: 58 | See Westphal 2006 |
Westphal et al. [74] | Long-term follow-up | New | Both | Surgery + CW + RT | Surgery + placebo + RT | Grade 3 or 4: 120; Grade 4 only: 101 | See Westphal 2003 | Grade 3 or 4: 15.8; grade 4 only: 10 |
Zhu et al. (abstr) [75] | RCS, SC | New | 4 | Surgery + CW | n/a | 57 | Not reported | 29.63 |
Study | 3-year OS (%) | Median survival (months) | Other treatment (N) | 1-year OS (%) | 2-year OS (%) | 3-year OS (%) | Median survival (months) |
---|---|---|---|---|---|---|---|
Affronti et al. [18] | 21 | 22.35 | 49 | 69 | 29 | 20 | 18.175 |
Anderson and Thomson (abstr) [19] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Aoki et al. [20] | Not reported | New diagnosis, grade 3 or 4: not calculable; new diagnosis, grade 4 only: 20.2; recurrent, grade 3 or 4: 12; recurrent, grade 4 only: 8.6 | n/a | n/a | n/a | n/a | n/a |
Attenello et al. [21] | Primary, grade 3: 58; primary, grade 4: 20; revision, grade 3: 29; revision, grade 4: 8 | Primary, grade 3: 57; primary: grade 4: 13.5; revision, grade 3: 23.6; revision, grade 4: 11.3 | n/a | n/a | n/a | n/a | n/a |
Barr and Grundy [22] | Primary: 10; revision: not reported | Primary: 15.3; revision: 7.5 | n/a | n/a | n/a | n/a | n/a |
Bock et al. [23] | 13 | 12.7 | n/a | n/a | n/a | n/a | n/a |
Brem et al. [24] | n/a | 11.5 | n/a | n/a | n/a | n/a | n/a |
Brem et al. [13] | 9 | 7.75 | 112 | 20 | 11 | 8 | 5.75 |
Catalán-Uribarrena et al. [25] | 11 | 13.4 | 55 | 43 | 18 | 11 | 11.0 |
Chaichana et al. [26] | 1 | 8.7 | 45 | 9 | 0 | 0 | 5.5 |
Damilakis 2011 (abstr) [27] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Darakchiev et al. [28] | 20 | 17.25 | n/a | n/a | n/a | n/a | n/a |
De Bonis et al. [29] | Not reported | New: 14; recurrent: 6 | New: 58 Recurrent: 60 | Not reported | Not reported | Not reported | New: 11; recurrent:9 |
Della Puppa et al. [30] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Della Puppa et al. [31] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
De’Santi et al. [32] | Not reported | 21 | n/a | n/a | n/a | n/a | n/a |
Desjardins et al. (abstr) [33] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Dörner et al. [34] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Duntze et al. [35] | Not reported | 18.8 | n/a | n/a | n/a | n/a | n/a |
Giese et al. [36] | Not reported | 14.7 | 13 | Not reported | Not reported | Not reported | 9.5 |
Gutenberg et al. [37] | Not reported | New diagnosis, without TMZ: 14.7; new diagnosis, with TMZ: 18.9; recurrent, unmethylated: 11.2; recurrent, methylated: 10 | n/a | n/a | n/a | n/a | n/a |
Ho et al. (abstr) [38] | Not reported | Not reported | 42 | Not reported | Not reported | Not reported | Not reported |
Hoffmann (abstr) [39] | Not reported | 19.5 | n/a | n/a | n/a | n/a | n/a |
Kleinberg 2004 [40] | Not reported | 12.8 | n/a | n/a | n/a | n/a | n/a |
Ko et al. [41] | Not reported | CW + I-125: 11.67; CW alone: 7; CW ± I-125: 11.2 | n/a | n/a | n/a | n/a | n/a |
Krex et al. (abstr) [42] | Not reported | 8.9 | n/a | n/a | n/a | n/a | n/a |
Kunwar et al. [43] | Not reported | 8.8 | 183 | 38 | 13 | Not reported | 9.1 |
Lechapt-Zalcman et al. [44] | 18.1 | 17.5 | n/a | n/a | n/a | n/a | n/a |
Lemcke et al. [45] | Not reported | 12.8 | 58 | Not reported | Not reported | Not reported | 11.4 |
Lopez et al. (abstr) [46] | Not reported | 26 | n/a | n/a | n/a | n/a | n/a |
McGirt et al. [47] | With TMZ: 32; no TMZ: 12 | With TMZ: 21.3; no TMZ: 12.4 | 45 | Not reported | Not reported | Not reported | 14.7 |
McGovern et al. [48] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Menei et al. [49] | Not reported | New: 17; recurrent: 7 | n/a | n/a | n/a | n/a | n/a |
Metellus et al. [6] | Not reported | 9.9 | n/a | n/a | n/a | n/a | n/a |
Metellus et al. (abstr) [50] | Not reported | 12.6 | n/a | n/a | n/a | n/a | n/a |
Miglierini et al. [51] | 15 | 19.2 | n/a | n/a | n/a | n/a | n/a |
Noël et al. [52] | Not reported | Grade 3 or 4: 20.6; grade 4 only: 20.8 | Grade 3 or 4: 37; grade 4 only: 16 | Grade 3 or 4: 78.4; grade 4 only: 62.5 | Grade 3 or 4: 33.3; grade 4 only: 0 | Not reported | Grade 3 or 4: 20.8; grade 4 only: 13.8 |
Pan et al. [53] | 24 | 17 | n/a | n/a | n/a | n/a | n/a |
Perez Gomez et al. [54] | 13.3 | 15 | n/a | n/a | n/a | n/a | n/a |
Qadri et al. (abstr) [55] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Qadri et al. (abstr) [56] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Quinn 2009 [57] | 5 | 12.575 | n/a | n/a | n/a | n/a | n/a |
Quiros [58] | Not reported | 20 | 35 | Not reported | Not reported | Not reported | 20 |
Ranjan et al. [59] | Not reported | 16.1 | n/a | n/a | n/a | n/a | n/a |
Rezazadeh et al. [abstr] [60] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Ryken (abstr) [61] | Not reported | 18.2 | n/a | n/a | n/a | n/a | n/a |
Salmaggi et al. [62] | Not reported | 17.8 | n/a | n/a | n/a | n/a | n/a |
Salvati et al. [63] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Samis Zella et al. [64] | Not reported | Not reported | 32 | Not reported | Not reported | Not reported | Not reported |
Satilmis et al. (abstr) [65] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Shah et al. [66] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Silvani et al. (abstr) [67] | Not reported | 23 | n/a | n/a | n/a | n/a | n/a |
Smith et al. [68] | 9 | 12.5 | n/a | n/a | n/a | n/a | n/a |
Subach et al. [69] | Not reported | 3.5 | 45 | 50 | Not reported | Not reported | 13.5 |
Sumrall et al. (abstr) [70] | 12 | 19.35 | n/a | n/a | n/a | n/a | n/a |
Uff et al. (abstr) [71] | Not reported | 15.25 | n/a | n/a | n/a | n/a | n/a |
Ulmer et al. [72] | Not reported | 10.4 (mean) | n/a | n/a | n/a | n/a | n/a |
Valtonen et al. [11] | Grade 3 or 4: 27; grade 4 only: 19 | Grade 3 or 4: 14.52; grade 4 only: 13.33 | Grade 3 or 4: 16; grade 4 only: 16 | Grade 3 or 4: 20; grade 4 only: 20 | Grade 3 or 4: 7; grade 4 only: 7 | Grade 3 or 4: 7; grade 4 only: 7 | Grade 3 or 4: 9.98; grade 4 only: 9.98 |
Watts et al. [73] | Not reported | Not reported | n/a | n/a | n/a | n/a | n/a |
Westphal et al. [12] | See Westphal 2006 | Grade 3 or 4: 13.8; grade 4 only: 13.1 | Grade 3 or 4: 120; grade 4 only: 106 | Grade 3 or 4: 49.6; grade 4 only: 48 | See Westphal 2006 | See Westphal 2006 | Grade 3 or 4: 11.6; grade 4 only: 11.4 |
Westphal et al. [74] | Grade 3 or 4: 9.2; grade 4 only: 1 | See Westphal 2003 | Grade 3 or 4: 120; grade 4 only: 106 | See Westphal 2003 | Grade 3 or 4: 8.3; grade 4 only: 5 | Grade 3 or 4: 1.7; Grade 4 only: 0 | See Westphal 2003 |
Zhu et al. (abstr) [75] | Not reported | 19.38 (mean) | n/a | n/a | n/a | n/a | n/a |