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08.07.2019 | Special Article

Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines

verfasst von: Joanne M. Bowen, Rachel J. Gibson, Janet K. Coller, Nicole Blijlevens, Paolo Bossi, Noor Al-Dasooqi, Emma H. Bateman, Karen Chiang, Charlotte de Mooij, Bronwen Mayo, Andrea M. Stringer, Wim Tissing, Hannah R. Wardill, Ysabella Z. A. van Sebille, Vinisha Ranna, Anusha Vaddi, Dorothy MK. Keefe, Rajesh V. Lalla, Karis Kin Fong Cheng, Sharon Elad, On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)

Erschienen in: Supportive Care in Cancer | Ausgabe 10/2019

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Abstract

Purpose

The aim of this study was to update the clinical practice guidelines for the use of agents for the prevention and/or treatment of gastrointestinal mucositis (GIM).

Methods

A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, and No Guideline Possible.

Results

A total of 78 papers across 13 interventions were examined of which 25 were included in the final review. No new guidelines were possible for any agent due to inadequate and/or conflicting evidence. Existing guidelines for probiotics and hyperbaric oxygen were unchanged.

Conclusions

Of the agents studied for the prevention and treatment of GIM, the evidence continues to support use of probiotics containing Lactobacillus spp. for prevention of chemoradiotherapy and radiotherapy-induced diarrhea in patients with pelvic malignancy, and hyperbaric oxygen therapy to treat radiation-induced proctitis. Additional well-designed research is encouraged to enable a decision regarding palifermin, glutamine, sodium butyrate, and dietary interventions, for the prevention or treatment of GIM.

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Titel: Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines
verfasst von: Joanne M. Bowen
Rachel J. Gibson
Janet K. Coller
Nicole Blijlevens
Paolo Bossi
Noor Al-Dasooqi
Emma H. Bateman
Karen Chiang
Charlotte de Mooij
Bronwen Mayo
Andrea M. Stringer
Wim Tissing
Hannah R. Wardill
Ysabella Z. A. van Sebille
Vinisha Ranna
Anusha Vaddi
Dorothy MK. Keefe
Rajesh V. Lalla
Karis Kin Fong Cheng
Sharon Elad
On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO)
Publikationsdatum: 08.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 10/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-019-04892-0

Springer Medizin

Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines