Skip to main content

2021 | OriginalPaper | Buchkapitel

49. Systemischer Lupus Erythematodes (SLE) (engl. Systemic lupus erythematosus)

verfasst von : Sibylle Winterhalter, F. Hiepe

Erschienen in: Entzündliche Augenerkrankungen

Verlag: Springer Berlin Heidelberg

Zusammenfassung

ICD-10-Code M32 Systemischer Lupus erythematodes, M32.1+ Systemischer Lupus erythematodes mit Beteiligung von Organen oder Organsystemen
Literatur
Zurück zum Zitat Alexander T, Radbruch A, Hiepe F (2015) Pathogenesis of systemic lupus erythematosus. Z Rheumatol 74(3):183–190PubMedCrossRef Alexander T, Radbruch A, Hiepe F (2015) Pathogenesis of systemic lupus erythematosus. Z Rheumatol 74(3):183–190PubMedCrossRef
Zurück zum Zitat Andreoli L, Bertsias GK, Agmon-Levin N et al (2017) EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis 76:476–485PubMedCrossRef Andreoli L, Bertsias GK, Agmon-Levin N et al (2017) EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis 76:476–485PubMedCrossRef
Zurück zum Zitat Arevalo JF, Lowder CY, Muci-Mendoza R (2002) Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmol 13:404–410PubMedCrossRef Arevalo JF, Lowder CY, Muci-Mendoza R (2002) Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmol 13:404–410PubMedCrossRef
Zurück zum Zitat Aringer M, Costenbader K, Daikh D et al (2019) 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Arthritits Rheum 71(9):1400–1412CrossRef Aringer M, Costenbader K, Daikh D et al (2019) 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Arthritits Rheum 71(9):1400–1412CrossRef
Zurück zum Zitat Arnett FC (1987) The HLA system and the genetics of lupus erythematosus. In: Wallace DJ, Dubois EL (Hrsg) Dubois’ lupus erythematosus, 3. Aufl. Lea and Febiger, Philadelphia, S 161–184 Arnett FC (1987) The HLA system and the genetics of lupus erythematosus. In: Wallace DJ, Dubois EL (Hrsg) Dubois’ lupus erythematosus, 3. Aufl. Lea and Febiger, Philadelphia, S 161–184
Zurück zum Zitat Asherson RA, Merry P, Acheson JF et al (1989) Antiphospholipid antibodies: a risk factor for occlusive ocular vascular disease in SLE and primary antiphospholipid syndrome. Ann Rheum Dis 48:358–361PubMedPubMedCentralCrossRef Asherson RA, Merry P, Acheson JF et al (1989) Antiphospholipid antibodies: a risk factor for occlusive ocular vascular disease in SLE and primary antiphospholipid syndrome. Ann Rheum Dis 48:358–361PubMedPubMedCentralCrossRef
Zurück zum Zitat Biesen R, Rose T, Hoyer BF et al (2016) Autoantibodies, complement and type I interferon as biomarkers for personalized medicine in SLE. Lupus 25(8):823–829PubMedCrossRef Biesen R, Rose T, Hoyer BF et al (2016) Autoantibodies, complement and type I interferon as biomarkers for personalized medicine in SLE. Lupus 25(8):823–829PubMedCrossRef
Zurück zum Zitat Chugh S, Darvish-Kazem S, Lim W et al (2015) Rituximab plus standard of care for treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Lancet Haematol 2(e):75–81CrossRef Chugh S, Darvish-Kazem S, Lim W et al (2015) Rituximab plus standard of care for treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Lancet Haematol 2(e):75–81CrossRef
Zurück zum Zitat Cobo-Ibáñez T, Loza-Santamaría E, Pego-Reigosa JM et al (2014) Efficacy and safety of rituximab in the treatment of non-renal systemic lupus erythematosus: a systematic review. Semin Arthritis Rheum 44:175–185PubMedCrossRef Cobo-Ibáñez T, Loza-Santamaría E, Pego-Reigosa JM et al (2014) Efficacy and safety of rituximab in the treatment of non-renal systemic lupus erythematosus: a systematic review. Semin Arthritis Rheum 44:175–185PubMedCrossRef
Zurück zum Zitat Costedoat-Chalumeau N, Dunogué B, Leroux G et al (2015) A critical review of the effects of hydroxychloroquine and chloroquine on the eye. Clin Rev Allergy Immunol 49:317–326PubMedCrossRef Costedoat-Chalumeau N, Dunogué B, Leroux G et al (2015) A critical review of the effects of hydroxychloroquine and chloroquine on the eye. Clin Rev Allergy Immunol 49:317–326PubMedCrossRef
Zurück zum Zitat Couturier A, Giocanti-Aurégan A, Dupas B et al (2017) Update on recommendations for screening for hydroxychloroquine retinopathy. J Fr Ophtalmol 40(9):793–800PubMedCrossRef Couturier A, Giocanti-Aurégan A, Dupas B et al (2017) Update on recommendations for screening for hydroxychloroquine retinopathy. J Fr Ophtalmol 40(9):793–800PubMedCrossRef
Zurück zum Zitat D’Cruz DP, Khamashat MA, Hughes GR (2007) Systemic lupus erythematosus. Lancet 369:587–596PubMedCrossRef D’Cruz DP, Khamashat MA, Hughes GR (2007) Systemic lupus erythematosus. Lancet 369:587–596PubMedCrossRef
Zurück zum Zitat Dammacco R (2018) Systemic lupus erythematosus and ocular involvement: an overview. Clin Exp Med 18(2):135–149PubMedCrossRef Dammacco R (2018) Systemic lupus erythematosus and ocular involvement: an overview. Clin Exp Med 18(2):135–149PubMedCrossRef
Zurück zum Zitat Dammacco R, Procaccio P, Racanelli V et al (2018) Ocular involvement in systemic lupus erythematosus: the experience of two tertiary referral centers. Ocul Immunol Inflamm 26(8):1154–1165PubMedCrossRef Dammacco R, Procaccio P, Racanelli V et al (2018) Ocular involvement in systemic lupus erythematosus: the experience of two tertiary referral centers. Ocul Immunol Inflamm 26(8):1154–1165PubMedCrossRef
Zurück zum Zitat Davies JB, Rao PK (2008) Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmol 19:512–518PubMedCrossRef Davies JB, Rao PK (2008) Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmol 19:512–518PubMedCrossRef
Zurück zum Zitat Fanouriakis A, Kostopoulou M, Alunno A et al (2019) 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis 78(6):736–745PubMedCrossRef Fanouriakis A, Kostopoulou M, Alunno A et al (2019) 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis 78(6):736–745PubMedCrossRef
Zurück zum Zitat Flechsig A, Rose T, Barkhudaraova F et al (2017) What is the clinical significance of anti-SM antibodies in systemic lupus erythematosus? A comparison with anti-dsDNA antibodies and C3. Clin Exp Rheumatol 35(4):598–606PubMed Flechsig A, Rose T, Barkhudaraova F et al (2017) What is the clinical significance of anti-SM antibodies in systemic lupus erythematosus? A comparison with anti-dsDNA antibodies and C3. Clin Exp Rheumatol 35(4):598–606PubMed
Zurück zum Zitat Gomez Mendes LM, Cascino MD, Garg J et al (2018) Peripheral blood B cell depletion after rituximab and complete response in lupus nephritis. Clin J Am Soc Nephrol 13:1502–1509CrossRef Gomez Mendes LM, Cascino MD, Garg J et al (2018) Peripheral blood B cell depletion after rituximab and complete response in lupus nephritis. Clin J Am Soc Nephrol 13:1502–1509CrossRef
Zurück zum Zitat Graham EM, Spalton DJ, Barnard RO et al (1985) Cerebral and retinal vascular changes in systemic lupus erythematosus. Ophthalmology 92:444–448PubMedCrossRef Graham EM, Spalton DJ, Barnard RO et al (1985) Cerebral and retinal vascular changes in systemic lupus erythematosus. Ophthalmology 92:444–448PubMedCrossRef
Zurück zum Zitat Grimson BS, Simons KB (1983) Orbital inflammation, myositis and systemic lupus erythematosus. Arch Opthalmol 101:736–738CrossRef Grimson BS, Simons KB (1983) Orbital inflammation, myositis and systemic lupus erythematosus. Arch Opthalmol 101:736–738CrossRef
Zurück zum Zitat Gross AJ, Hochberg D, Rand WM et al (2005) EBV and systemic lupus erythematosus: a new perspective. J Immunol 174:6599–6607PubMedCrossRef Gross AJ, Hochberg D, Rand WM et al (2005) EBV and systemic lupus erythematosus: a new perspective. J Immunol 174:6599–6607PubMedCrossRef
Zurück zum Zitat Hall S, Buettner H, Luthra HS (1984) Occlusive retinal vascular disease in systemic lupus erythematosus. J Rheumatol 11:846–850PubMed Hall S, Buettner H, Luthra HS (1984) Occlusive retinal vascular disease in systemic lupus erythematosus. J Rheumatol 11:846–850PubMed
Zurück zum Zitat Herold G (2002) Systemischer Lupus Erythematodes, Lupusnephritis. In: Herold G (Hrsg) Innere Medizin. Springer-Verlag, Köln, S 551–554 Herold G (2002) Systemischer Lupus Erythematodes, Lupusnephritis. In: Herold G (Hrsg) Innere Medizin. Springer-Verlag, Köln, S 551–554
Zurück zum Zitat Huey C, Jakobiec FA, Iwarmoto T et al (1983) Discoid lupus erythematosus of the eyelids. Ophthalmology 90:1389–1398PubMedCrossRef Huey C, Jakobiec FA, Iwarmoto T et al (1983) Discoid lupus erythematosus of the eyelids. Ophthalmology 90:1389–1398PubMedCrossRef
Zurück zum Zitat Iaccarino L, Andreoli L, Bocci EB et al (2018) Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. Results of a lage, multicentric, nationwide study. J Autoimmun 86:1–8PubMedCrossRef Iaccarino L, Andreoli L, Bocci EB et al (2018) Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. Results of a lage, multicentric, nationwide study. J Autoimmun 86:1–8PubMedCrossRef
Zurück zum Zitat Jabs DA, Miller NR, Newman SA et al (1986) Optic neuropathy in systemic lupus erythematosus. Arch Ophthalmol 104:564–568PubMedCrossRef Jabs DA, Miller NR, Newman SA et al (1986) Optic neuropathy in systemic lupus erythematosus. Arch Ophthalmol 104:564–568PubMedCrossRef
Zurück zum Zitat Kasitanon N, Intaniwet T, Wangkaew S et al (2015) The clinically quiescent phase in early-diagnosed SLE patients: inception cohort study. Rheumatology 54:868–875PubMedCrossRef Kasitanon N, Intaniwet T, Wangkaew S et al (2015) The clinically quiescent phase in early-diagnosed SLE patients: inception cohort study. Rheumatology 54:868–875PubMedCrossRef
Zurück zum Zitat Kim J-W, Kim YY, Lee H et al (2017) Risk of retinal toxicity in longterm users of hydroxychloroquine. J Rheumatol 44:1674–1679PubMedCrossRef Kim J-W, Kim YY, Lee H et al (2017) Risk of retinal toxicity in longterm users of hydroxychloroquine. J Rheumatol 44:1674–1679PubMedCrossRef
Zurück zum Zitat Klinkhoff AV, Beattie CW, Chalmers A (1986) Retinopathy in systemic lupus erythematosus: relationship to disease activity. Arthritis Rheum 29:1152–1156PubMedCrossRef Klinkhoff AV, Beattie CW, Chalmers A (1986) Retinopathy in systemic lupus erythematosus: relationship to disease activity. Arthritis Rheum 29:1152–1156PubMedCrossRef
Zurück zum Zitat Kuhn A, Bonsmann G, Anders HJ (2015) The diagnosis and treatment of systemic lupus erythematosus. Dtsch Arztebl Int 112:423–432PubMedPubMedCentral Kuhn A, Bonsmann G, Anders HJ (2015) The diagnosis and treatment of systemic lupus erythematosus. Dtsch Arztebl Int 112:423–432PubMedPubMedCentral
Zurück zum Zitat Kuhn A, Aberer E, Bata-Csörgő Z et al (2017) S2k guideline for the treatment of cutaneous lupus erythematosus – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 31:389–404 Kuhn A, Aberer E, Bata-Csörgő Z et al (2017) S2k guideline for the treatment of cutaneous lupus erythematosus – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 31:389–404
Zurück zum Zitat Mackensen F, Rosenbaum JT, Max R (2011) Augenbeteiligung bei systemischem Lupus erythematodes. In: Joussen AM (Hrsg) Retinale Gefäßerkrankungen. Springer, Heidelberg, S 351–356 Mackensen F, Rosenbaum JT, Max R (2011) Augenbeteiligung bei systemischem Lupus erythematodes. In: Joussen AM (Hrsg) Retinale Gefäßerkrankungen. Springer, Heidelberg, S 351–356
Zurück zum Zitat Md Yusof MY, Shaw D, El-Sherbiny YM et al (2017) Predicting and managing primary and secondary non-response to rituximab using B-cell biomarkers in systemic lupus erythematosus. Ann Rheum Dis 76:1829–1836PubMedCrossRef Md Yusof MY, Shaw D, El-Sherbiny YM et al (2017) Predicting and managing primary and secondary non-response to rituximab using B-cell biomarkers in systemic lupus erythematosus. Ann Rheum Dis 76:1829–1836PubMedCrossRef
Zurück zum Zitat Melles RB, Marmor MF (2014) The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. JAMA Ophthalmol 132:1453–1460PubMedCrossRef Melles RB, Marmor MF (2014) The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. JAMA Ophthalmol 132:1453–1460PubMedCrossRef
Zurück zum Zitat Merrill JT, Neuwelt CM et al (2010) Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 62(1):222–233PubMedPubMedCentralCrossRef Merrill JT, Neuwelt CM et al (2010) Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 62(1):222–233PubMedPubMedCentralCrossRef
Zurück zum Zitat Miescher PA (1986) Treatment of systemic lupus erythematosus. Springer Semin Immunopathol 9:271–282PubMedCrossRef Miescher PA (1986) Treatment of systemic lupus erythematosus. Springer Semin Immunopathol 9:271–282PubMedCrossRef
Zurück zum Zitat Nguyen QD, Uy HS, Akpek EK et al (2000) Choroidopathy in systemic lupus erythematosus. Arch Ophthalmol 106:230–234 Nguyen QD, Uy HS, Akpek EK et al (2000) Choroidopathy in systemic lupus erythematosus. Arch Ophthalmol 106:230–234
Zurück zum Zitat Olfat M, Silverman ED, Levy DM (2015) Rituximab therapy has a rapid and durable response for refractory cytopenia in childhood-onset systemic lupus erythematosus. Lupus 24:966–972PubMedCrossRef Olfat M, Silverman ED, Levy DM (2015) Rituximab therapy has a rapid and durable response for refractory cytopenia in childhood-onset systemic lupus erythematosus. Lupus 24:966–972PubMedCrossRef
Zurück zum Zitat Ordi-Ros J, Sáez-Comet L, Pérez-Cones M et al (2017) Enteric-coated mycophenolate sodium versus azathioprine in patients with active systemic lupus erythematosus: a randomized clinical trial. Ann Rheum Dis 76:1575–1582PubMedCrossRef Ordi-Ros J, Sáez-Comet L, Pérez-Cones M et al (2017) Enteric-coated mycophenolate sodium versus azathioprine in patients with active systemic lupus erythematosus: a randomized clinical trial. Ann Rheum Dis 76:1575–1582PubMedCrossRef
Zurück zum Zitat Osio-Salido E, Manapat- Reyes H (2010) Epidemiology of systemic lupus erythemtosus in Asia. Lupus 19:1365–1373PubMedCrossRef Osio-Salido E, Manapat- Reyes H (2010) Epidemiology of systemic lupus erythemtosus in Asia. Lupus 19:1365–1373PubMedCrossRef
Zurück zum Zitat Petri M, Kim MY, Kalunian KC et al (2005) Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med 353:2250–2258CrossRef Petri M, Kim MY, Kalunian KC et al (2005) Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med 353:2250–2258CrossRef
Zurück zum Zitat Prabu A, Marshall T, Gordon C et al (2003) Use of patient age and anti-R/La antibody status to determine the probability of patients with systemic lupus erythematosus and sicca symptoms fulfilling criteria for secondary Sjögren’s syndrome. Rheumatology (Oxford) 42:189–191CrossRef Prabu A, Marshall T, Gordon C et al (2003) Use of patient age and anti-R/La antibody status to determine the probability of patients with systemic lupus erythematosus and sicca symptoms fulfilling criteria for secondary Sjögren’s syndrome. Rheumatology (Oxford) 42:189–191CrossRef
Zurück zum Zitat Ramos-Casals M, Soto MJ et al (2009) Rituximab in systemic lupus erythematosus: a systematic review of of-label use in 188 cases. Lupus 18(9):767–776PubMedCrossRef Ramos-Casals M, Soto MJ et al (2009) Rituximab in systemic lupus erythematosus: a systematic review of of-label use in 188 cases. Lupus 18(9):767–776PubMedCrossRef
Zurück zum Zitat Sakthiaswary R, Suresh E (2014) Methotrexate in systemic lupus erythematosus: a systematic review of its efficacy. Lupus 23:225–235CrossRef Sakthiaswary R, Suresh E (2014) Methotrexate in systemic lupus erythematosus: a systematic review of its efficacy. Lupus 23:225–235CrossRef
Zurück zum Zitat Sánchez- Guerrero J, Uribe AG, Jiménez- Santana L et al (2005) A trial of contraceptive methods in women with systemic luspus erythematosus. N Engl J Med 353:2539–2549PubMedCrossRef Sánchez- Guerrero J, Uribe AG, Jiménez- Santana L et al (2005) A trial of contraceptive methods in women with systemic luspus erythematosus. N Engl J Med 353:2539–2549PubMedCrossRef
Zurück zum Zitat Serris A, Amoura Z, Canouï-Poitrine F et al (2018) Efficacy and safety of rituximab for systemic lupus erythematosus-associated immune cytopenias: a multicenter retrospective cohort study of 71 adults. Am J Hematol 93:424–429PubMedCrossRef Serris A, Amoura Z, Canouï-Poitrine F et al (2018) Efficacy and safety of rituximab for systemic lupus erythematosus-associated immune cytopenias: a multicenter retrospective cohort study of 71 adults. Am J Hematol 93:424–429PubMedCrossRef
Zurück zum Zitat Silpa-archa S, Lee JJ, Foster CS (2016) Ocular manifestations in systemic lupus erythematosus. Br J Ophthalmol 100(1):135–141PubMedCrossRef Silpa-archa S, Lee JJ, Foster CS (2016) Ocular manifestations in systemic lupus erythematosus. Br J Ophthalmol 100(1):135–141PubMedCrossRef
Zurück zum Zitat Sitaula R, Shah DN, Singh D (2011) The spectrum of ocular involvement in systemic lupus erythamtosus in a tertiary eye care center in Nepal. Ocul Immunol Inflamm 19(6):422–425PubMedCrossRef Sitaula R, Shah DN, Singh D (2011) The spectrum of ocular involvement in systemic lupus erythamtosus in a tertiary eye care center in Nepal. Ocul Immunol Inflamm 19(6):422–425PubMedCrossRef
Zurück zum Zitat Staffort- Brady FJ, Urowitz MB, Gladmann DD et al (1988) Lupus retinopathy: patterns, associations and prognosis. Arthritis Rheum 31:1105–1110CrossRef Staffort- Brady FJ, Urowitz MB, Gladmann DD et al (1988) Lupus retinopathy: patterns, associations and prognosis. Arthritis Rheum 31:1105–1110CrossRef
Zurück zum Zitat Steiman AJ, Urowitz MB, Ibañez D et al (2014) Prolonged clinical remission in patients with systemic lupus erythematosus. J Rheumatol 41:1808–1816PubMedCrossRef Steiman AJ, Urowitz MB, Ibañez D et al (2014) Prolonged clinical remission in patients with systemic lupus erythematosus. J Rheumatol 41:1808–1816PubMedCrossRef
Zurück zum Zitat Tan EM, Cohen AS et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–1277PubMedCrossRef Tan EM, Cohen AS et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–1277PubMedCrossRef
Zurück zum Zitat Taraborelli M, Leuenberger L, Lazzaroni MG et al (2016) The contribution of antiphospholipid antibodies to organ damage in systemic lupus erythematosus. Lupus 25:1365–1368PubMedCrossRef Taraborelli M, Leuenberger L, Lazzaroni MG et al (2016) The contribution of antiphospholipid antibodies to organ damage in systemic lupus erythematosus. Lupus 25:1365–1368PubMedCrossRef
Zurück zum Zitat Teoh SC, Yap EY, Eong KG (2001) Neuro-ophthalmological manifestations of systemic lupus erythematosus in Asian patients. Clin Exp Ophthalmol 29:213–216PubMedCrossRef Teoh SC, Yap EY, Eong KG (2001) Neuro-ophthalmological manifestations of systemic lupus erythematosus in Asian patients. Clin Exp Ophthalmol 29:213–216PubMedCrossRef
Zurück zum Zitat Tolba DA, El-Fayoumi DMS, Abdelaziz MS et al (2017) Fluorescein angiographic findings in patients with active systemic lupus erythematosus. Ocul Immunol Inflamm 25(6):884–890PubMedCrossRef Tolba DA, El-Fayoumi DMS, Abdelaziz MS et al (2017) Fluorescein angiographic findings in patients with active systemic lupus erythematosus. Ocul Immunol Inflamm 25(6):884–890PubMedCrossRef
Zurück zum Zitat Tselios K, Gladman DD, Su J et al (2016) Mycophenolate mofetil in nonrenal manifestations of systemic lupus erythematosus: an observational cohort study. J Rheumatol 43:552–558PubMedCrossRef Tselios K, Gladman DD, Su J et al (2016) Mycophenolate mofetil in nonrenal manifestations of systemic lupus erythematosus: an observational cohort study. J Rheumatol 43:552–558PubMedCrossRef
Zurück zum Zitat Ugarte-Gil MF, Wojdyla D, Pons-Estel GJ et al (2017) Remission and low disease activity status (LDAS) protect lupus patients from damage occurrence: data from a multiethnic, multinational Latin American lupus cohort (GLADEL). Ann Rheum Dis 76:2071–2074PubMedCrossRef Ugarte-Gil MF, Wojdyla D, Pons-Estel GJ et al (2017) Remission and low disease activity status (LDAS) protect lupus patients from damage occurrence: data from a multiethnic, multinational Latin American lupus cohort (GLADEL). Ann Rheum Dis 76:2071–2074PubMedCrossRef
Zurück zum Zitat Vital EM, Wittmann M, Edward S et al (2015) Brief report: responses to rituximab suggest B cell-independent inflammation in cutaneous systemic lupus erythematosus. Arthritis Rheum 67:1586–1591CrossRef Vital EM, Wittmann M, Edward S et al (2015) Brief report: responses to rituximab suggest B cell-independent inflammation in cutaneous systemic lupus erythematosus. Arthritis Rheum 67:1586–1591CrossRef
Zurück zum Zitat Walport MJ (2002) Complement and systemic lupus erythematosus. Arthritis Res 4(3):279–293CrossRef Walport MJ (2002) Complement and systemic lupus erythematosus. Arthritis Res 4(3):279–293CrossRef
Zurück zum Zitat Yehudai D, Shoenfeld Y, Toubi E (2007) Looking into the eyes of patients with antiphospholipid syndrome. Clinic Rev Allerg Immunol 32:192–197CrossRef Yehudai D, Shoenfeld Y, Toubi E (2007) Looking into the eyes of patients with antiphospholipid syndrome. Clinic Rev Allerg Immunol 32:192–197CrossRef
Metadaten
Titel
Systemischer Lupus Erythematodes (SLE) (engl. Systemic lupus erythematosus)
verfasst von
Sibylle Winterhalter
F. Hiepe
Copyright-Jahr
2021
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-60399-4_49

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Die Verwendung von Ophthalmika in der Schwangerschaft und Stillzeit stellt immer eine Off-label-Anwendung dar. Ein Einsatz von Arzneimitteln muss daher besonders sorgfältig auf sein Risiko-Nutzen-Verhältnis bewertet werden. In der vorliegenden …

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Vitrektomie Originalie

Die endogene Endophthalmitis ist eine hämatogen fortgeleitete, bakterielle oder fungale Infektion, die über choroidale oder retinale Gefäße in den Augapfel eingeschwemmt wird [ 1 – 3 ]. Von dort infiltrieren die Keime in die Netzhaut, den …

Bakterielle endogene Endophthalmitis

Vitrektomie Leitthema

Eine endogene Endophthalmitis stellt einen ophthalmologischen Notfall dar, der umgehender Diagnostik und Therapie bedarf. Es sollte mit geeigneten Methoden, wie beispielsweise dem Freiburger Endophthalmitis-Set, ein Keimnachweis erfolgen. Bei der …

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Die bestmögliche Wundheilung der Kornea, insbesondere ohne die Ausbildung von lichtstreuenden Narben, ist oberstes Gebot, um einer dauerhaften Schädigung der Hornhaut frühzeitig entgegenzuwirken und die Funktion des Auges zu erhalten.   

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.