Background
Methods
Study population
Platelet function testing
Study protocol
Statistical analysis
Results
Clinical and demographic data
Variable | Clopidogrel Low-Responder | Clopidogrel Responder | OR (95% CI) | p-Value |
---|---|---|---|---|
No. (%) | 155 (30.8) | 349 (69.2) | ||
Female gender (%) | 54 (34.8) | 101 (28.9) | 1.31 (0.88-1.97) | n.s. (0.21) |
Age (years) | 64.5 (11.5) | 64.4 (11.7) | n.s. (0.93) | |
BMI (kg/m2) | 28.06 (5.00) | 27.81 (4.20) | n.s. (0.56) | |
EF (%) | 52.82 (12.50) | 54.23 (10.50) | n.s. (0.19) | |
Acute coronary syndrome | 122 (78.7) | 214 (61.3) | 2.33 (1.50-3.63) | <0.001 |
Arterial hypertension | 124 (80.0) | 282 (80.8) | 0.95 (0.59-1.53) | n.s. (0.90) |
Diabetes mellitus | 74 (47.7) | 124 (35.5) | 1.66 (1.13-2.43) | 0.01 |
Lipid disorder | 95 (61.3) | 211 (60.5) | 1.04 (0.70-1.53) | n.s. (0.92) |
Cigarette smoking | 68 (43.9) | 157 (45.0) | 0.96 (0.65-1.40) | n.s. (0.85) |
Familial CAD disposition | 33 (21.3) | 63 (18.1) | 1.23 (0.77-1.97) | n.s. (0.39) |
ASA 100 mg | 153 (98.7) | 349 (100) | 0.09 (0.01-1.84) | n.s. (0.09) |
Beta-Blockers | 138 (89.0) | 302 (86.5) | 1.26 (0.70-2.28) | n.s. (0.47) |
Nitrates | 24 (15.5) | 72 (20.6) | 0.70 (0.42-1.17) | n.s. (0.22) |
Calcium-channel blockers | 49 (31.6) | 101 (28.9) | 1.14 (0.75-1.71) | n.s. (0.60) |
ACE Inhibitors | 133 (85.8) | 301 (86.2) | 0.96 (0.56-1.66) | n.s. (0.89) |
Diuretics | 73 (47.1) | 138 (39.5) | 1.36 (0.93-1.99) | n.s. (0.12) |
Statins | 125 (80.6) | 269 (77.1) | 1.24 (0.77-1.98) | n.s. (0.41) |
Proton pump inhibitors | 62 (40.0) | 151 (43.3) | 0.87 (0.59-1.29) | n.s. (0.56) |
Number of drugs | 7.69 (2.30) | 7.36 (2.30) | n.s. (0.14) | |
WBC (×109/l) | 9.22 (4.17) | 8.71 (6.10) | n.s. (0.34) | |
Hemoglobin (g/dl) | 14.12 (1.60) | 14.28 (1.90) | n.s. (0.36) | |
Platelet count (×109/l) | 230.34 (69.62) | 212.00 (87.97) | 0.02 | |
Troponin positive (%) | 35 (22.6) | 37 (10.6) | 2.46 (1.48-4.09) | <0.001 |
CK max (U/l) | 428.85 (1246.60) | 391.61 (783.70) | n.s. (0.68) | |
Total cholesterol (mg/dl) | 203.70 (57.30) | 204.37 (50.10) | n.s. (0.89) | |
CRP (mg/l) | 11.47 (20.70) | 7.34 (15.40) | 0.01 | |
HbA1C (%) | 6.71 (1.60) | 6.42 (1.30) | 0.03 | |
D-dimer (mg/l) | 0.57 (0.50) | 0.57 (0.40) | n.s. (1.00) | |
Serum creatinine (mg/dl) | 1.06 (0.60) | 1.04 (0.30) | n.s. (0.62) | |
GFR (MDRD) (ml/min) | 76.34 (24.20) | 75.87 (20.90) | n.s. (0.82) | |
PREDICT-score | 3.38 (2.0) | 2.48 (1.90) | <0.001 | |
ASA low-response | 44 (28.4) | 31 (8.9) | 4.07 (2.45-6.76) | <0.001 |
Variable | ASA Low-Responder | ASA Responder | OR (95% CI) | p-Value |
---|---|---|---|---|
No. (%) | 78 (19.4) | 325 (80.6) | ||
Female gender (%) | 19 (24.4) | 101 (31.1) | 0.71 (0.40-1.26) | n.s. (0.27) |
Age (years) | 63.80 (12.90) | 64.30 (11.70) | n.s. (0.74) | |
BMI (kg/m2) | 28.17 (5.10) | 27.81 (4.30) | n.s. (0.52) | |
EF (%) | 52.78 (13.90) | 54.35 (11.10) | n.s. (0.29) | |
Acute coronary syndrome | 61 (78.2) | 211 (64.9) | 1.94 (1.08-3.48) | 0.03 |
Arterial hypertension | 62 (79.5) | 258 (79.4) | 1.01 (0.54-1.86) | n.s. (1.0) |
Diabetes mellitus | 38 (48.7) | 113 (34.8) | 1.78 (1.08-2.94) | 0.03 |
Lipid disorder | 44 (56.4) | 193 (59.4) | 0.89 (0.54-1.46) | n.s. (0.70) |
Cigarette smoking | 33 (42.3) | 148 (45.5) | 0.88 (0.53-1.45) | n.s. (0.62) |
Familial CAD disposition | 10 (12.8) | 68 (20.9) | 0.56 (0.27-1.14) | n.s. (0.11) |
Beta-Blockers | 71 (91.0) | 279 (85.8) | 1.67 (0.72-3.86) | n.s. (0.27) |
Nitrates | 8 (10.3) | 71 (21.8) | 0.41 (0.19-0.89) | 0.03 |
Calcium-channel blockers | 25 (32.0) | 90 (27.7) | 1.23 (0.72-2.10) | n.s. (0.49) |
ACE Inhibitors | 67 (85.9) | 276 (84.9) | 1.08 (0.53-2.19) | n.s. (1.0) |
Diuretics | 39 (50.0) | 124 (38.2) | 1.62 (0.99-2.67) | n.s. (0.07) |
Statins | 58 (74.4) | 257 (79.1) | 0.77 (0.43-1.36) | n.s. (0.36) |
Proton pump inhibitors | 29 (37.2) | 147 (45.2) | 0.72 (0.43-1.19) | n.s. (0.21) |
Number of drugs (n ± SD) | 7.50 (2.80) | 7.48 (2.20) | 1.67 (0.72-3.86) | n.s. (0.95) |
WBC (×109/l) | 9.80 (4.10) | 8.70 (5.40) | 0.09 | |
Hemoglobin (g/dl) | 14.71 (2.40) | 14.07 (1.50) | 0.003 | |
Platelet count (×109/l) | 250.33 (10.22) | 205.80 (63.69) | <0.001 | |
Troponin positive (%) | 34 (43.6) | 53 (16.3) | 3.97 (2.32-6.78) | <0.001 |
CK max (U/l) | 478.15 (1508.40) | 529.77 (638.70) | n.s. (0.64) | |
Total cholesterol (mg/dl) | 205.63 (60.60) | 202.14 (51.30) | n.s. (0.60) | |
CRP (mg/l) | 12.26 (21.40) | 7.22 (15.40) | 0.02 | |
HbA1C (%) | 6.88 (1.70) | 6.41 (1.30) | 0.007 | |
D-dimer (mg/l) | 0.78 (0.60) | 1.02 (2.70) | n.s. (0.44) | |
Serum creatinine (mg/dl) | 1.14 (0.80) | 1.02 (0.30) | 0.03 | |
GFR (MDRD) (ml/min) | 81.50 (59.70) | 78.16 (22.30) | n.s. (0.42) | |
PREDICT score | 3.39 (2.20) | 2.55 (1.80) | <0.001 | |
Clopidogrel low-response | 44 (56.4) | 74 (22.8) | 4.39 (2.62-7.36) | <0.001 |