Erschienen in:
01.12.2000 | Paper Report
TANK-binding kinase 1 activates NF-?B
verfasst von:
Andy Finch
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2000
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Excerpt
The involvement of the tumour necrosis factor receptor (TNFR)-associated factor (TRAF) family of proteins in NF-?B and c-Jun amino-terminal kinase (JNK) activation by pro-inflammatory cytokines has been well documented. NF-?B activation by TRAFs occurs through NF-?B-inducing kinase (NIK), and the I?B kinase (IKK), leading to I?B phosphorylation and degradation. TRAF associated NF-?B activator (TANK) is a TRAF-binding protein which can activate NF-?B in a TRAF-dependent fashion yet inhibits NF-?B activation by pro-inflammatory cytokines. This article describes the identification of a TANK-binding kinase, TBK1, which mediates the TANK/TRAF-dependent activation of NF-?B and proposes that TANK and TBK1 can compete with pro-inflammatory receptor complexes in the activation of NF-?B. To clarify the seemingly contradictory role of TANK in the NF-?B pathway by identifying and characterising other molecules which interact with TANK. …
