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Erschienen in:
03.06.2020 | Original Research Article
Targeting CD79b for Chimeric Antigen Receptor T-Cell Therapy of B-Cell Lymphomas
Erschienen in: Targeted Oncology | Ausgabe 3/2020
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Background
Although chimeric antigen receptor (CAR) T-cell therapy targeting antigens expressed in refractory and relapsed non-Hodgkin B-cell lymphoma, such as CD19 and CD22, has achieved encouraging clinical effects, some patients fail to attain remission, or relapse after CAR T-cell therapy, which has been ascribed to the loss of the target antigens.
Objective
To evaluate CD79b as an alternative target for CAR T-cell B-cell lymphoma therapy.
Patient and methods
The expression of CD79b in different B-cell lymphomas was determined. Anti-CD79b CAR T-cells expressing one of two different CARs were generated, and a series of in vitro and in vivo experiments were conducted to assess the CAR T-cell function.
Results
We found that CD79b was extensively expressed on the tumor cells of patients with various types of lymphoma regardless of stage, subtype, and cytogenetic and molecular features. Anti-CD79b CAR T-cells were highly specific and effective for the treatment of B-cell lymphomas.
Conclusions
Our data indicate that CD79b could be used as a target for CAR T-cell therapy of B-cell lymphomas, and further clinical development is warranted.