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Inflammopharmacology

Erschienen in:

20.08.2017 | Original Article

Teniposide ameliorates bone cancer nociception in rats via the P2X7 receptor

verfasst von: Jingjia Yan, Jiaxiao Sun, Zhiyuan Zeng

Erschienen in: Inflammopharmacology | Ausgabe 2/2018

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Abstract

Bone pain associated with advanced tumor metastasis is the most severe threat to life quality of patients. Highly efficient and low-toxic therapeutics is of urgent need for this complication. Bone tumor metastasis was established by direct bone inoculation of Walker 256 mammary gland carcinoma cells. Bone nociception was measured by mechanical allodynia, thermal hyperalgesia and spontaneous flinches. P2X7R level was determined by immunoblotting. The inward current was recorded by a patch clamp. The related cytokines were determined by ELISA. Our results showed that teniposide (TN) treatment significantly ameliorated bone nociception associated with tumor inoculation to a comparable extent with P2X7-specific inhibitor, BBG, in rat model. The efficient blockade of inward current generation and pro-inflammatory cytokines secretion were observed upon administration with TN. Our data highlighted the therapeutic potency of TN in this complication associated with tumor metastasis and warrants further clinical investigations.

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Titel: Teniposide ameliorates bone cancer nociception in rats via the P2X7 receptor
verfasst von: Jingjia Yan
Jiaxiao Sun
Zhiyuan Zeng
Publikationsdatum: 20.08.2017
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 2/2018
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-017-0388-2

Springer Medizin

Abstract

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