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Journal of Mammary Gland Biology and Neoplasia
Erschienen in: Journal of Mammary Gland Biology and Neoplasia 4/2007

01.12.2007

TGFβ as a Potential Mediator of Progesterone Action in the Mammary Gland of Pregnancy

verfasst von: Jenifer Monks

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 4/2007

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Abstract

The molecular mechanisms controlling the onset of copious milk secretion are only now beginning to be elucidated. We have known for nearly four decades that progesterone suppresses milk secretion during pregnancy, and that the fall in progesterone near parturition is necessary for secretory activation. Similarly, we’ve known for 15 years that transforming growth factor β (TGFβ) also suppresses milk secretion. Yet no formal link between the two has ever been established. This work aims to review the evidence for and against a link between progesterone and TGFβ, raise unanswered questions, and to propose further lines of research.
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Metadaten
Titel
TGFβ as a Potential Mediator of Progesterone Action in the Mammary Gland of Pregnancy
verfasst von
Jenifer Monks
Publikationsdatum
01.12.2007
Verlag
Springer US
Erschienen in
Journal of Mammary Gland Biology and Neoplasia / Ausgabe 4/2007
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-007-9056-2

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