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Journal of Mammary Gland Biology and Neoplasia
Erschienen in: Journal of Mammary Gland Biology and Neoplasia 4/2007

01.12.2007

The Role of Glucocorticoids in Secretory Activation and Milk Secretion, a Historical Perspective

verfasst von: Theresa M. Casey, Karen Plaut

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 4/2007

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Abstract

In this review we present our current understanding of the role of glucocorticoids in secretory activation and milk secretion by looking at the literature from a historical perspective. We begin with the early endocrine ablation experiments and continue from there to show that glucocorticoids are not just necessary for secretory activation and milk secretion—but mandatory. Specifically, we discuss the importance of glucocorticoids to: (1) induce the formation of ultrastructural components necessary to support milk synthesis and secretion, including rough endoplasmic reticulum and tight junction sealing; (2) regulate milk protein gene expression; and (3) prevent the second phase of involution, possibly by preventing the breakdown of the extracellular matrix.
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Metadaten
Titel
The Role of Glucocorticoids in Secretory Activation and Milk Secretion, a Historical Perspective
verfasst von
Theresa M. Casey
Karen Plaut
Publikationsdatum
01.12.2007
Verlag
Springer US
Erschienen in
Journal of Mammary Gland Biology and Neoplasia / Ausgabe 4/2007
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-007-9055-3

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