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Tumor Biology
Erschienen in: Tumor Biology 12/2015

01.12.2015 | Research Article

TGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer

verfasst von: Guo Xiang, Yang Yi, He Weiwei, Wu Weiming

Erschienen in: Tumor Biology | Ausgabe 12/2015

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Abstract

Transforming growth factor beta-inducing factor 1 (TGIF1) was reported to be dysregulated in several types of cancer. However, its expression pattern and functions in nonsmall cell lung cancer (NSCLC) remained unknown. In the present study, the expression of TGIF1 was found to be elevated in the clinical NSCLC tissues. TGIF1 promoted the growth and migration of NSCLC cells, while knocking down the expression of TGIF1 inhibited the growth and migration of NSCLC cells. Moreover, downregulation of TGIF1 impaired the metastasis of NSCLC cells. In the study for the molecular mechanisms, it was found that TGIF1 positively regulated beta-catenin/TCF signaling. In summary, our study demonstrated the oncogenic role of TGIF1 in NSCLC, and TGIF1 might be a therapeutic target for NSCLC.
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Metadaten
Titel
TGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer
verfasst von
Guo Xiang
Yang Yi
He Weiwei
Wu Weiming
Publikationsdatum
01.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 12/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3676-8

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