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01.12.2015 | Research Article

Extracellular vesicles from women with breast cancer promote an epithelial-mesenchymal transition-like process in mammary epithelial cells MCF10A

verfasst von: Octavio Galindo-Hernandez, Cristina Gonzales-Vazquez, Pedro Cortes-Reynosa, Emmanuel Reyes-Uribe, Sonia Chavez-Ocaña, Octavio Reyes-Hernandez, Mónica Sierra-Martinez, Eduardo Perez Salazar

Erschienen in: Tumor Biology | Ausgabe 12/2015

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Abstract

Extracellular vesicles (EVs) mediate many stages of tumor progression including angiogenesis, escape from immune surveillance, and extracellular matrix degradation. We studied whether EVs from plasma of women with breast cancer are able to induce an epithelial-mesenchymal transition (EMT) process in mammary epithelial cells MCF10A. Our findings demonstrate that EVs from plasma of breast cancer patients induce a downregulation of E-cadherin expression and an increase of vimentin and N-cadherin expression. Moreover, EVs induce migration and invasion, as well as an increase of NFκB-DNA binding activity and MMP-2 and MMP-9 secretions. In summary, our findings demonstrate, for the first time, that EVs from breast cancer patients induce an EMT-like process in human mammary non-tumorigenic epithelial cells MCF10A.

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Titel: Extracellular vesicles from women with breast cancer promote an epithelial-mesenchymal transition-like process in mammary epithelial cells MCF10A
verfasst von: Octavio Galindo-Hernandez
Cristina Gonzales-Vazquez
Pedro Cortes-Reynosa
Emmanuel Reyes-Uribe
Sonia Chavez-Ocaña
Octavio Reyes-Hernandez
Mónica Sierra-Martinez
Eduardo Perez Salazar
Publikationsdatum: 01.12.2015
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 12/2015
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-015-3711-9

Springer Medizin

Extracellular vesicles from women with breast cancer promote an epithelial-mesenchymal transition-like process in mammary epithelial cells MCF10A

Abstract

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Springer Medizin

Abstract

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