Erschienen in:
Open Access
01.12.2012 | Poster presentation
Th17 is involved in the pathogenesis of Bechet's disease via CCL20-CCR6 axis
verfasst von:
Hidekata Yasuoka, Zhu Chen, Tsutomu Takeuchi, Masataka Kuwana
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
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Excerpt
Behcet's disease (BD) is an autoinflammatory disease with a unique distribution characterized by uveitis, and mucosal and skin lesions, which are characterized by the prominent infiltration of immune cells such as lymphocytes and neutrophils. A novel helper T-cell subset Th17, IL-17-producing helper T cells, has been appreciated [
1]. IL-17 is involved in the induction of a series of chemokines, growth factors, proteases, and cytokines, and production of IL-17 results in induction of neutrophil migration and chronic inflammation [
2]. Based on these findings, we hypothesized that Th17 is involved in the pathogenesis of BD. …