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01.01.2011 | Preclinical study

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells

verfasst von: Ming Shi, Dan Liu, Huijun Duan, Lu Qian, Lina Wang, Lijia Niu, Huipeng Zhang, Zheng Yong, Zehui Gong, Lun Song, Ming Yu, Meiru Hu, Qing Xia, Beifen Shen, Ning Guo

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2011

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Abstract

In this study, β2-AR level was found to be up-regulated in MCF-7 cells overexpressing Her2 (MCF-7/Her2). Correlation of β2-AR level with Her2 status was demonstrated in breast cancer tissue samples. Constitutive phosphorylation of ERK, mRNA expression up-regulation of catecholamine-synthesis enzymes, and increased epinephrine release were detected in MCF-7/Her2 cells. β2-AR expression induced by epinephrine and involvement of ERK signaling were validated. The data indicate that Her2 overexpression and excessive phosphorylation of ERK cause epinephrine autocrine release from breast cancer cells, resulting in up-regulation of β2-AR expression. The data also showed that catecholamine prominently stimulated Her2 mRNA expression and promoter activity. The activation and nuclear translocation of STAT3 triggered by isoproterenol were observed. Enhanced binding activities of STAT3 to the Her2 promoter after isoproterenol stimulation were verified. Using STAT3 shRNA and dominant negative STAT3 mutant, the role of STAT3 in isoproterenol-induced Her2 expression was further confirmed. The data support a model where β2-AR and Her2 comprise a positive feedback loop in human breast cancer cells.

Pierce KL, Premont RT, Lefkowitz RJ (2002) Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3:639–650CrossRefPubMed

Neves SR, Ram PT, Iyengar R (2002) G protein pathways. Science 296:1636–1639CrossRefPubMed

Spiegel AM, Weinstein LS (2004) Inherited diseases involving g proteins and g protein-coupled receptors. Annu Rev Med 55:27–39CrossRefPubMed

Dang H, Elliott JJ, Lin AL et al (2008) Mitogen-activated protein kinase up-regulation and activation during rat parotid gland atrophy and regeneration: role of epidermal growth factor and beta2-adrenergic receptors. Differentiation 76:546–557CrossRefPubMed

Daub H, Weiss FU, Wallasch C et al (1996) Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379:557–560CrossRefPubMed

Gavi S, Shumay E, Wang HY et al (2006) G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation. Trends Endocrinol Metab 17:48–54CrossRefPubMed

van Biesen T, Hawes BE, Raymond JR et al (1996) G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J Biol Chem 271:1266–1269CrossRefPubMed

Rao GN, Delafontaine P, Runge MS (1995) Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells. J Biol Chem 270:27871–27875CrossRefPubMed

Daub H, Wallasch C, Lankenau A et al (1997) Signal characteristics of G protein-transactivated EGF receptor. EMBO J 16:7032–7044CrossRefPubMed

10.

Herrlich A, Daub H, Knebel A et al (1998) Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. Proc Natl Acad Sci USA 95:8985–8990CrossRefPubMed

11.

Prenzel N, Zwick E, Daub H et al (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884–888PubMed

12.

Baselga J, Swain SM (2009) Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer 9:463–475CrossRefPubMed

13.

Lohrisch C, Piccart M (2001) An overview of HER2. Semin Oncol 28:3–11CrossRefPubMed

14.

Shang ZJ, Liu K, de Liang F (2009) Expression of beta2-adrenergic receptor in oral squamous cell carcinoma. J Oral Pathol Med 38:371–376CrossRefPubMed

15.

Ramberg H, Eide T, Krobert KA et al (2008) Hormonal regulation of beta2-adrenergic receptor level in prostate cancer. Prostate 68:1133–1142CrossRefPubMed

16.

Yang EV, Kim SJ, Donovan EL et al (2009) Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav Immun 23:267–275CrossRefPubMed

17.

Negro A, Brar BK, Gu Y et al (2006) erbB2 is required for G protein-coupled receptor signaling in the heart. Proc Natl Acad Sci USA 103:15889–15893CrossRefPubMed

18.

Yuan G, Qian L, Shi M et al (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3. Cell Signal 20:1284–1291CrossRefPubMed

19.

Smyth LM, Bobalova J, Mendoza MG et al (2004) Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. J Biol Chem 279:48893–48903CrossRefPubMed

20.

Hu P, Zhou T, Qian L et al (2006) Sequestering ErbB2 in endoplasmic reticulum by its autoinhibitor from translocation to cell surface: an autoinhibition mechanism of ErbB2 expression. Biochem Biophys Res Commun 342:19–27CrossRefPubMed

21.

Nagatsu T, Levitt M, Udenfriend S (1964) Tyrosine hydroxylase: the initial step in norepinephrine biosynthesis. J Biol Chem 239:2910–2917PubMed

22.

Fernstrom MH, Baker RL, Fernstrom JD (1989) In vivo tyrosine hydroxylation rate in retina: effects of phenylalanine and tyrosine administration in rats pretreated with p-chlorophenylalanine. Brain Res 499:291–298CrossRefPubMed

23.

Ribeiro P, Pigeon D, Kaufman S (1991) The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells. J Biol Chem 266:16207–16211PubMed

24.

Iuvone PM, Galli CL, Garrison-Gund CK et al (1978) Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons. Science 202:901–902CrossRefPubMed

25.

Landen CN Jr, Lin YG, Armaiz Pena GN et al (2007) Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer. Cancer Res 67:10389–10396CrossRefPubMed

26.

Qian L, Chen L, Shi M et al (2006) A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells. Biochem Biophys Res Commun 345:660–668CrossRefPubMed

27.

Dhanasekaran N, Heasley LE, Johnson GL (1995) G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr Rev 16:259–270PubMed

28.

van Biesen T, Luttrell LM, Hawes BE et al (1996) Mitogenic signaling via G protein-coupled receptors. Endocr Rev 17:698–714CrossRefPubMed

29.

Liu X, Wu WK, Yu L et al (2008) Epidermal growth factor-induced esophageal cancer cell proliferation requires transactivation of beta-adrenoceptors. J Pharmacol Exp Ther 326:69–75CrossRefPubMed

30.

Faure M, Voyno-Yasenetskaya TA, Bourne HR (1994) cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem 269:7851–7854PubMed

31.

Cakir Y, Plummer HK III, Tithof PK et al (2002) Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines. Int J Oncol 21:153–157PubMed

32.

Fitzgerald PJ (2009) Is norepinephrine an etiological factor in some types of cancer? Int J Cancer 124:257–263CrossRefPubMed

33.

Palermo-Neto J, de Oliveira Massoco C, Robespierre de Souza W (2003) Effects of physical and psychological stressors on behavior, macrophage activity, and Ehrlich tumor growth. Brain Behav Immun 17:43–54CrossRefPubMed

34.

Brenner GJ, Felten SY, Felten DL et al (1992) Sympathetic nervous system modulation of tumor metastases and host defense mechanisms. J Neuroimmunol 37:191–201CrossRefPubMed

35.

van Biesen T, Hawes BE, Luttrell DK et al (1995) Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature 376:781–784CrossRefPubMed

36.

Luttrell LM, Della Rocca GJ, van Biesen T et al (1997) Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J Biol Chem 272:4637–4644CrossRefPubMed

37.

Li YM, Pan Y, Wei Y et al (2004) Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 6:459–469CrossRefPubMed

38.

Yang EV, Sood AK, Chen M et al (2006) Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 66:10357–10364CrossRefPubMed

39.

Metcalfe C, Davey Smith G, Macleod J et al (2007) The role of self-reported stress in the development of breast cancer and prostate cancer: a prospective cohort study of employed males and females with 30 years of follow-up. Eur J Cancer 43:1060–1065CrossRefPubMed

40.

Thornton LM, Andersen BL, Carson WE III (2008) Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis. Cancer Immunol Immunother 57:1471–1481CrossRefPubMed

41.

Smythies J (2005) Section III. The norepinephrine system. Int Rev Neurobiol 64:173–211CrossRefPubMed

Titel: The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells
verfasst von: Ming Shi
Dan Liu
Huijun Duan
Lu Qian
Lina Wang
Lijia Niu
Huipeng Zhang
Zheng Yong
Zehui Gong
Lun Song
Ming Yu
Meiru Hu
Qing Xia
Beifen Shen
Ning Guo
Publikationsdatum: 01.01.2011
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2011
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-010-0822-2

Springer Medizin

The β2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells

Abstract

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