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12.06.2017 | Original Article

The analgesic effect of trans-resveratrol is regulated by calcium channels in the hippocampus of mice

verfasst von: Weijie Wang, Yingcong Yu, Jing Li, Lin Wang, Zhi Li, Chong Zhang, Linlin Zhen, Lianshu Ding, Gang Wang, Xiaoyang Sun, Ying Xu

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2017

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Abstract

Resveratrol has been widely studied in terms of it’s potential to slow the progression of many diseases. But little is known about the mechanism of action in neuropathic pain. Neuropathic pain is the main type of chronic pain associated with tissue injury. Calcium channels and calcium/caffeine-sensitive pools are associated with analgesic pathway involving neuropathic pain. Our previous study suggested that the antinociceptive effect of resveratrol was involved in Ca²⁺/calmodulin-dependent signaling in the spinal cord of mice. The aim of this study was to explore the involvement of Ca²⁺ in analgesic effects of trans-resveratrol in neuropathic pain and signal pathway in hippocampus. Hot plate test was used to assess antinociceptive response when mice were treated with trans-resveratrol alone or in combination with Mk 801, nimodipine, CaCl₂, ryanodine or EGTA. The effects of trans-resveratrol and the combination on Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) and BDNF (brain-derived neurotrophic factor) expression in hippocampus were also investigated. The results showed that trans-resveratrol increased paw withdraw latency in the hot plate test. The effect of resveratrol was enhanced by Mk 801 and nimodipine. Central administration of Ca²⁺, however, abolished the antinociceptive effects of resveratrol. In contrast, centrally administered EGTA or ryanodine improved trans-resveratrol induced antinociception. There was a significant increase in p-CaMKII and BDNF expression in the hippocampus when resveratrol were combined with Mk 801, nimodipine, ryanodine and EGTA. Administration of CaCl₂ blocked changes in p-CaMKII and BDNF levels in the hippocampus. These findings suggest that trans-resveratrol exerts the effects of antinociception through regulation of calcium channels and calcium/caffeine-sensitive pools.

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Titel: The analgesic effect of trans-resveratrol is regulated by calcium channels in the hippocampus of mice
verfasst von: Weijie Wang
Yingcong Yu
Jing Li
Lin Wang
Zhi Li
Chong Zhang
Linlin Zhen
Lianshu Ding
Gang Wang
Xiaoyang Sun
Ying Xu
Publikationsdatum: 12.06.2017
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 4/2017
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0033-1

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