Erschienen in:
01.11.2007 | Concise Article
The anti-cancer effects of quinolone antibiotics?
verfasst von:
M. Paul, A. Gafter-Gvili, A. Fraser, L. Leibovici
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
|
Ausgabe 11/2007
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Abstract
A previous meta-analysis showed that quinolones administered for prophylaxis of infections among cancer patients reduced all-cause mortality. We extracted from the primary trials infection-related and all-cause mortality as reported and assessed the effect of quinolones on non-infection-related mortality through meta-analysis. Among trials comparing quinolones to placebo or no treatment, a significant reduction in non-infection-related mortality was observed (relative risk 0.54, 95% confidence interval 0.32–0.93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities.