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Journal of Gastrointestinal Cancer

Erschienen in:

29.08.2019 | Review Article

The Anticancer Efficiency of Citrullus colocynthis Toward the Colorectal Cancer Therapy

verfasst von: Manal Khalid Abdulridha, Ali-H Al-Marzoqi, Abdolmajid Ghasemian

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 2/2020

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Abstract

Background

Colorectal cancer (CRC) remains a major cause of death worldwide. Chemotherapy is associated with some side effects during CRC treatment. Hence, proper employment of lower toxic and approaches exerting lowest side effects are essential. The Citrullus colocynthis (C. colocynthis) seems a potential anticancerous herbal medicine (HM) against CRC mostly via various efficient compounds.

Methods

We performed a literature review regarding the anticancer traits of C. colocynthis against CRC. The possible active compounds, mechanisms, and combination therapies in vitro and in vivo or clinical trials have been also stated where found.

Results and Conclusion

The anticancerous effects of C. colocynthis has been via a variety of pathways including apoptotic pathways (increase in caspase-3 and inhibiting STAT3 function), antioxidant and anti-inflammatory (TNF-α, nitric oxide, and pro-inflammatory cytokines such as IL-6, IL-8, and IL-1α) traits, inhibition of Wnt/β-catenin signaling pathway, and antiangiogenesis and antimetastatic effects. Future studies will be promising regarding proper application of C. colocynthis compounds following their extraction.

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Titel: The Anticancer Efficiency of Citrullus colocynthis Toward the Colorectal Cancer Therapy
verfasst von: Manal Khalid Abdulridha
Ali-H Al-Marzoqi
Abdolmajid Ghasemian
Publikationsdatum: 29.08.2019
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 2/2020
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-019-00299-6

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Springer Medizin

The Anticancer Efficiency of Citrullus colocynthis Toward the Colorectal Cancer Therapy

Abstract

Background

Methods

Results and Conclusion

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Springer Medizin

Abstract

Background

Methods

Results and Conclusion

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