The association between low birth weight and dental caries among 11-to-13-year-old school age children in Ningbo, China

Low birth weight (LBW) risk factors, such as maternal diabetes, hypertension, obesity, and older age, have been on the rise, making LBW a major public health issue in China [1]. A 2013 epidemiological survey showed that the incidence of LBW (common in preterm babies) in China was 6.1% (< 2500 g) [2]. Advances in technology have decreased the mortality rate due to LBW. However, complications, such as respiratory disorders and oral problems, have been reported in patients with LBW [3, 4]. Previous studies found that LBW and preterm children result in poor dental health and hygiene [4].

The incidence of dental caries is influenced by genetic, socioeconomic and early life factors [5‐8]. Prematurity and LBW have been found to only affect the enamel structure of the primary teeth since permanent teeth mineralize only after birth. In recent years, some studies have shown that birth outcomes affect the ameloblasts during the secretory or maturation phase of tooth development, causing both hypoplastic and hypomineralized enamel [9‐12]. The defects affect the permanent incisors and first molars during permanent dentition. To date, the association of LBW with dental caries is unclear [4, 13‐16]. Furthermore, as far as we know, no study has investigated this in China.

Therefore, we investigated the association of LBW with dental caries in permanent teeth of Chinese children.

A total of 8702 11-to-13-year-old school age children received pit and fissure closure and their parents were provided with a questionnaire. Two thousand one questionnaires subsequently recruited from 10 regions, using a stratified sampling method (23.0%). Missing answers and illogical data were resolved by contacting parents via a telephone interview. A total of 1975 children (22.7%) with complete information were enrolled. The Kappa values used to assess inter-examiner and intra-examiner reproducibility ranged from 0.81 to 0.96.

The mean age of the 1975 children was 11.3 (SD = 0.5). Among them were 1013 (51.2%) males and 962 (48.8%) females. A total of 610 children (30.9%) had dental caries in permanent teeth. Specifically, the prevalence of dental caries in LBW children and normal birth weight (NBW) children was 38.3 and 30.3%, respectively. The mean DMFS of all subjects was 0.65 (SD = 1.2), and the mean DMFS of LBW children and NBW children was 0.84 (SD = 1.3) and 0.63 (SD = 1.2), respectively.

The sample and the population distributions in the 10 Ningbo Province regions are shown in Table 1. The characteristics of the study population are prescribed in Table 2. The mean birth weight of the entire study sample was 3, 332.1 g, and the prevalence of LBW was 6.5%. About 70% of the subjects consumed sugary foods less than once a day, and more than 40% were over 3 years old before starting to brush. About 74% of children brushed teeth ≥2 times daily, and 70% received dental examination at least once a year. Approximately 54% of the children used fluoride agents. Of note, most dietary habits and lifestyles were similar between LBW children and NBW children.

The association of LBW with dental caries in permanent teeth is shown in Table 3. There was no association between LBW and dental caries in permanent teeth after adjusting for confounding factors.

In this cross-sectional study, LBW was not associated with dental caries. This is consistent with findings in a retrospective cohort research in the USA, which found no increased risk of caries in very low birth weight (VLBW) group [3]. However, the study in USA did not distinguish posteruptive enamel loss in hypomineralized areas from caries in permanent molars and incisors. A previous retrospective cohort study conducted in Dubai found different results. It was found that enamel defects and dental caries in permanent teeth were significantly higher in the preterm group than in the full-term group in 5-to-10-year-old children [21]. Hypomineralization has been found to increases susceptibility to dental caries. The relationship between LBW and hypomineralization is currently unclear. A cross-sectional study involving 420 8 years old children in Thailand reported that LBW was not associated with molar incisor hypomineralization [22] while other similar studies found an association between the two [23, 24].

Several factors may explain these inconsistencies. For instance, some studies may have examined for dental caries at an age when dental caries had not developed, hence the association of LBW and dental caries was not detected [25, 26]. Therefore, the age of caries assessment should be investigated in future studies. Kay [27] reported that dental caries should be assessed at least 2 years after teeth eruption, to provide enough time for teeth decay. The inconsistencies may also be caused by different methodologies across studies. Nondifferential measurement error cannot be avoidable in a cross-sectional study. Furthermore, different confounding factors, which limits the feasibility of inter-study comparisons. Therefore, findings from previous studies are inconsistent and cannot be used to draw a clear conclusion applicable to all populations.

This study examined the relationship between LBW and dental caries in permanent teeth among children aged 11-13 years. Previous investigations focused on the influence of LBW on primary teeth [13, 21, 28]. The impacts of LBW on permanent teeth, especially permanent incisors and first molars, primarily originate from the secretory phase of the ameloblast. It begins in utero, and the maturation phase starts at birth. If inadequate mineralization or trauma occurs during these periods, the enamel defects appear, increasing the risk of caries [3, 29].

Several factors may explain the lack of association between LBW and dental caries in permanent teeth. LBW babies receive more attention and adequate nutritional intake from guardians than NBW infants [30]. Besides, their guardians are more proactive in implementing health and oral health instructions, consistent with findings by Gravina [31]. Specifically, Gravina [31] showed that premature children have lower rates of caries than term children because of appropriate oral health care and regular pediatric care. Furthermore, premature birth and LBW cause delayed teeth eruption, reducing caries information, thus minimizing the risk of dental caries [30, 32].

This study has several advantages. The participants were homogeneous in terms of age and geographic background. Detailed information, such as the frequency of sugary food intake, the frequency of brushing and starting age, regular dental check-ups were collected, making it easier to control for confounding factors. Birth weight was obtained from the hospital health booklet, suggesting that the data was accurate. Besides, the study included a large number of participants, which reduces contingency.

Nevertheless, there are some limitations worth mentioning. The outcomes may vary across different populations due to various cultural and social factors. The participants were from an economically developed area, and hence the present findings may not be applicable to other sites. Moreover, some limitations of a cross-sectional study such as selection bias and recall bias, could not be avoided. Furthermore, we did not assess the small for gestational age (SGA) that precisely evaluates intrauterine growth restriction [33].

In this cross-sectional study, LBW was not associated with dental caries in permanent teeth in children from Ningbo, Zhejiang province. However, it is likely that such an association exists in other areas. Further prospective studies should be conducted to verify the relationship between the LBW and dental caries in permanent teeth.