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Current Nutrition Reports

Erschienen in:

01.03.2014 | Cancer (MF Leitzmann, Section Editor)

The Association Between Physical Activity and Breast Cancer Recurrence and Survival

verfasst von: Nancy Urbscheit, Kent Brown

Erschienen in: Current Nutrition Reports | Ausgabe 1/2014

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Abstract

Recreational physical activity improves the prognosis of women who have been diagnosed with breast cancer. Numerous studies reveal that the level of prediagnostic recreational physical activity has a linear relationship with survival after diagnosis. Risk of recurrence of cancer also drops in women who exercised prediagnosis. Women who continue or start exercising after diagnosis also receive a significant protective benefit from mortality and recurrence. However, the physiological mechanisms of and the influence of menopause on these prognostic benefits have yet to be clearly defined.

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10.••

Friedenreich CM, Gregory J, Kopciuk KA, et al. Prospective cohort study of lifetime physical activity and breast cancer survival. Int J cancer. 2009;124:1954–62. This study adds to the findings of Abrahamson et al. (2006). It is one of the most detailed and thorough recent studies. It has a very large cohort, provides detailed data on physical activity (recreational, household, occupational, and MET levels), has a long follow-up after diagnosis, and examines multiple disease outcomes (recurrences, new primaries, and death from breast cancer and all causes). The study is currently the most thorough on the positive survival benefit of physical activity prediagnosis.PubMedCrossRef

11.••

Holmes MD, Chen WY, Feskanich D. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293:2479–86. This study was important, because it was one of the first to provide a detailed examination of the role of postdiagnostic exercise on the prognosis of breast cancer. This article should be read first by those who have a clinical/research interest in the role of exercise after diagnosis.PubMedCrossRef

12.••

Chen X, Lu W, Zheng W, et al. Exercise after diagnosis of breast cancer in association with survivial. Cancer Prev Res. 2011;4:1409–18. This work adds further information to that generated by Holmes et al. (2005), revealing an inverse relationship between intensity of postdiagnosis exercise and risk of mortality.CrossRef

13.••

Irwin ML, McTiernan A, Manson JE, et al. Physical activity and survival in postmenopausal women with breast cancer: results from the women’s health initiative. Cancer Prev Res. 2011;4:522–9. This study is quite recent and builds a bridge between the studies that examined survival benefit of physical activity prediagnosis and those that examined benefit of activity postdiagnosis. The study reveals that activity can be initiated after diagnosis to yield a survival benefit and increasing a prior level of activity can further increase the benefit.CrossRef

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15.••

Abrahamson PE, Gammon MD, Lund MJ, et al. Recreational Physical activity and survival among young women with breast cancer. Cancer. 2006;107:1777–85. This study is a primary work leading a series of recent works on the survival benefit of physical activity before diagnosis. The study had a large cohort and compares some specific features of women who have received survival benefits from prediagnostic physical activity to those who have not.PubMedCrossRef

16.•

West-Wright CN, Henderson KD, Sullivan-Halley J. Long-term and recent recreational physical activity and survival after breast cancer; the California teachers study. Cancer Epidemiol Biomarkers Prev. 2009;18:2851–9. This study specifically examined mortality rates in women who exercised before diagnosis and revealed a reduction related to intensity of physical activity.PubMedCentralPubMedCrossRef

17.

Peel JB, Sui X, Adams SA, Herbert JR, et al. A prospective study of cardiorespiratory fitness and 6 breast cancer mortality. Med Sci Sports Exer. 2009;41:742–8.CrossRef

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Emaus A, Vierod MB, Tretli S, et al. Metabolic profile, physical activity and, mortality in breast cancer patients. Breast Cancer Res Treat. 2010;121:651–60.PubMedCrossRef

19.•

Cleveland RJ, Eng SM, Stevens J, et al. Influence of prediagnostic recreational physical activity on survival from breast cancer. Eur J Can Prev. 2012;2:46–54. This study continued investigation of specific characteristics of prediagnostic physical activity on the survival of women after diagnosis. MET levels were used to quantify physical activity. The study included a lifetime assessment of prediagnostic exercise, which had not been done before, supporting the suggestion that exercise closer to the time of diagnosis is more likely to improve prognosis.CrossRef

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Keegan THM, Milne RL, Andrulis IL. Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the breast cancer family registry. Breast Cancer Res Treat. 2010;123:531–42. doi:10.1007/s10549-010- 0774-6.PubMedCentralPubMedCrossRef

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Pinkston C, Baumgartner R, Baumgartner KB. Abstract A81 Physical Activity and survival in long-term Hispanic and non-Hispanic white breast cancer survivors. Cancer Epidemiol Biomarkers Prev. 2011;20:A81.CrossRef

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Schmidt ME, Chang-Claude J, Seibold P, et al. Association of pre-diagnosis physical activity with recurrence and mortality among women with breast cancer. Int J Cancer. 2013;133:1431–40. doi:10.1002/ijc.28130. Epub 2013 March 18.PubMedCrossRef

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24.•

Beasley JM, Kwan ML, Chen WY, et al. Meeting the physical activity guidelines and survival after breast cancer: findings from the after breast cancer pooling project. Breast Cancer Res Treat. 2012;131:637–43. This study is valuable, because it pools data from a series of large studies and is written with the intention of providing guidelines for clinicians treating patients postdiagnosis. A level of MET hr/wk expected to provide a protective effect was presented.PubMedCentralPubMedCrossRef

25.•

Holick CM, Newcomb PA, Trentham-Dietz A, et al. Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:379–86. This study examined the association of total recreational activity and intensity of activity with survival benefit. The study found that increasing total activity may be more important than trying to increase vigor of activity, which may be an important factor for clinicians when advising patients on physical activity.PubMedCrossRef

26.•

Sternfeld B, Weltzien E, Quesenberry CP, et al. Physical activity and risk of recurrence and mortality in breast cancer survivors: finding from the LACE study. Cancer Epidemiol Biomarkers Prev. 2009;18:87–95. This study further strengthened the observation that moderate-intensity activity is more likely to improve prognosis than high-intensity activity. It also raises the concept that risk of recurrence of breast cancer is not associated with physical activity in the same way as risk of mortality.PubMedCentralPubMedCrossRef

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George SM, Smith AW, Alfano CM, et al. The Association between television watching time and all-cause mortality after breast cancer. J Cancer Surviv. 2013;10:247–52.CrossRef

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Cadmus-Bertram LA, Stefanick ML, Saquib N, et al. Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: finding from the WHEL study. Cancer Causes Control. 2011;22:427–35. This study examines the association of increases in physical activity after diagnosis and risk of recurrence. It also raises the issue that risk of recurrence may follow a different pattern of benefit from physical activity than the risk of mortality.CrossRef

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Titel: The Association Between Physical Activity and Breast Cancer Recurrence and Survival
verfasst von: Nancy Urbscheit
Kent Brown
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Current Nutrition Reports / Ausgabe 1/2014
Elektronische ISSN: 2161-3311
DOI: https://doi.org/10.1007/s13668-013-0067-x

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