Erschienen in:
Open Access
01.12.2012 | Poster presentation
The bacterial effector protein YopM reduces rheumatoid arthritis (RA) outcome by inhibiting inflammation and bone destruction
verfasst von:
J Bertrand, C Rueter, C Cromme, J Scharnert, A Schmidt, T Pap
Erschienen in:
Arthritis Research & Therapy
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Sonderheft 1/2012
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Excerpt
Osteoclasts mediate the degradation of bone during RA and are derived from macrophages. The yersinia outer protein M (YopM) is an effector protein of Yersinia species that is able to enter host cells by membrane penetration. In the cell YopM mediates down-regulation of inflammatory responses. We investigated whether YopM has the potential to act as a "selfdelivering" immune therapeutic agent by reducing the inflammation and joint destruction linked to RA. …