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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Urology 1/2015

The beneficial effect of alpha-blockers for ureteral stent-related discomfort: systematic review and network meta-analysis for alfuzosin versus tamsulosin versus placebo

Zeitschrift:
BMC Urology > Ausgabe 1/2015
Autoren:
Jong Kyou Kwon, Kang Su Cho, Cheol Kyu Oh, Dong Hyuk Kang, Hyungmin Lee, Won Sik Ham, Young Deuk Choi, Joo Yong Lee
Wichtige Hinweise

Competing interests

All the authors declare that they have no competing interests.

Authors’ contributions

Systematic review and meta-analysis JYL, KJK, KSC, DHK, HL, WSH, YDC. Identification of studies, critical evaluation and discussion. JYL, KJK, KSC, CKO, DHK, HL. All authors read and approved the final manuscript.

Abstract

Background

This study was carried out a network meta-analysis of evidence from randomized controlled trials (RCTs) to evaluate stent-related discomfort in patients with alfuzosin or tamsulosin versus placebo.

Methods

Relevant RCTs were identified from electronic databases. The proceedings of appropriate meetings were also searched. Seven articles on the basis of RCTs were included in our meta-analysis. Using pairwise and network meta-analyses, comparisons were made by qualitative and quantitative syntheses. Evaluation was performed with the Ureteric Stent Symptoms Questionnaire to assess the urinary symptom score (USS) and body pain score (BPS).

Results

One of the seven RCTs was at moderate risk of bias for all quality criteria; two studies had a high risk of bias. In the network meta-analysis, both alfuzosin (mean difference [MD];−4.85, 95 % confidence interval [CI];−8.53–−1.33) and tamsulosin (MD;−8.84, 95 % CI;−13.08–−4.31) showed lower scores compared with placebo; however, the difference in USS for alfuzosin versus tamsulosin was not significant (MD; 3.99, 95 % CI;−1.23–9.04). Alfuzosin (MD;−5.71, 95 % CI;−11.32–−0.52) and tamsulosin (MD;−7.77, 95 % CI;−13.68–−2.14) showed lower scores for BPS compared with placebo; however, the MD between alfuzosin and tamsulosin was not significant (MD; 2.12, 95 % CI;−4.62–8.72). In the rank-probability test, tamsulosin ranked highest for USS and BPS, and alfuzosin was second.

Conclusion

The alpha-blockers significantly decreased USS and BPS in comparison with placebo. Tamsulosin might be more effective than alfuzosin.
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