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01.10.2017 | ORIGINAL ARTICLE

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom

verfasst von: Daryl C. Yang, James Dobson, Chip Cochran, Daniel Dashevsky, Kevin Arbuckle, Melisa Benard, Leslie Boyer, Alejandro Alagón, Iwan Hendrikx, Wayne C. Hodgson, Bryan G. Fry

Erschienen in: Neurotoxicity Research | Ausgabe 3/2017

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Abstract

Coral snake envenomations are well characterized to be lethally neurotoxic. Despite this, few multispecies, neurotoxicity and antivenom efficacy comparisons have been undertaken and only for the Micrurus genus; Micruroides has remained entirely uninvestigated. As the USA’s supplier of antivenom has currently stopped production, alternative sources need to be explored. The Mexican manufacturer Bioclon uses species genetically related to USA species, thus we investigated the efficacy against Micrurus fulvius (eastern coral snake), the main species responsible for lethal envenomations in the USA as well as additional species from the Americas. The use of Coralmyn® coral snake antivenom was effective in neutralizing the neurotoxic effects exhibited by the venom of M. fulvius but was ineffective against the venoms of Micrurus tener, Micrurus spixii, Micrurus pyrrhocryptus, and Micruroides euryxanthus. Our results suggest that the Mexican antivenom may be clinically useful for the treatment of M. fulvius in the USA but may be of only limited efficacy against the other species studied.

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Ahmad Rusmili MR, Yee TT, Mustafa MR, Othman I, Hodgson WC (2014) In-vitro neurotoxicity of two Malaysian krait species (Bungarus candidus and Bungarus fasciatus) venoms: neutralization by monovalent and polyvalent antivenoms from Thailand. Toxins 6:1036–1048CrossRefPubMedCentral

Aird SD, Jorge da Silva N (1991) Comparative enzymatic composition of Brazilian coral snake (Micrurus) venoms. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 99:287–294CrossRef

Angulo Y, Estrada R, Gutitrrez J (1997) Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom. Toxicon 35:81–90CrossRefPubMed

Benard Valle M (2009) Similitud Bioquímica e inmunoquímica entre venenos de coralillos norteamericanos (Undergraduate thesis, Universidad Nacional Autonoma de Mexico). Cuernavaca, Mexico

Bénard-Valle M, Carbajal-Saucedo A, De Roodt A, López-Vera E, Alagón A (2014) Biochemical characterization of the venom of the coral snake Micrurus tener and comparative biological activities in the mouse and a reptile model. Toxicon 77:6–15. doi:10.1016/j.toxicon.2013.10.005 CrossRefPubMed

Bolanos R, Cerdas L, Taylor R (1975) The production and characteristics of a coral snake Micrurus-Mipartitus-Hertwigi antivenin. Toxicon 13(2):139–142CrossRefPubMed

Boyer L, Alagon A, Fry BG, Jackson TNW, Sunagar K, Chippaux JP (2015) Signs, symptoms, and treatment of envenomation. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. Oxford University Press, New York

Bucaretchi F, Capitani EM, Vieira RJ, Rodrigues CK, Zannin M Jr, Da Silva NJ Jr, Casais-e-Silva LL, Hyslop S (2016) Coral snake bites (Micrurus spp.) in Brazil: a review of literature reports. Clin Toxicol 54:222–234CrossRef

Camargo TM, de Roodt AR, da Cruz-Höfling MA, Rodrigues-Simioni L (2011) The neuromuscular activity of Micrurus pyrrhocryptus venom and its neutralization by commercial and specific coral snake antivenoms. Journal of Venom Research 2:24–31PubMedPubMedCentral

Campbell JA, Lamar WW (1989) The venomous reptiles of Latin America. Custom Publishing Associates, New York

Campbell JA, Lamar WW (2004) Venomous reptiles of the Western Hemisphere (Vol. 1): Comstock Pub. Associates.

Carbajal-Saucedo A, López-Vera E, Bénard-Valle M, Smith EN, Zamudio F, de Roodt AR, Olvera-Rodríguez A (2013) Isolation, characterization, cloning and expression of an alpha-neurotoxin from the venom of the Mexican coral snake Micrurus laticollaris (Squamata: Elapidae). Toxicon : Official Journal of the International Society on Toxinology 66:64–74. doi:10.1016/j.toxicon.2013.02.006 CrossRef

Crachi MT, Hammer LW, Hodgson WC (1999) The effects of antivenom on the in vitro neurotoxicity of venoms from the taipans, Oxyuranus scutellatus, Oxyuranus microlepidotus and Oxyuranus scutellatus canni. Toxicon 37:1771–1778CrossRefPubMed

Fernández J, Alape-Girón A, Angulo Y, Sanz L, Gutiérrez JM, Calvete JJ, Lomonte B (2011) Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae). J Proteome Res 10(4):1816–1827. doi:10.1021/pr101091a CrossRefPubMed

Fernandez J, Vargas-Vargas N, Pla D, Sasa M, Rey-Suárez P, Sanz L, Gutiérrez JM, Calvete JJ, Lomonte B (2015) Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids. Toxicon 107(Part B):217–233CrossRefPubMed

Fry BG, Lumsden NG, Wuster W, Wickramaratna JC, Hodgson WC, Kini R (2003) Micrurus isolation of a neurotoxin (alpha-colubritoxin) from a nonvenomous colubrid: evidence for early origin of venom in snakes. J Mol Evol 57:446–452CrossRefPubMed

Heyborne WH, Mackessy SP (2013) Identification and characterization of a taxon-specific three-finger toxin from the venom of the Green Vinesnake (Oxybelis fulgidus; family Colubridae). Biochimie 95:1923–1932CrossRefPubMed

Hodgson WC, Eriksson CO, Alewood PF, Fry BG (2003) A comparison of the in vitro neuromuscular activity of venom from three Australian snakes, Hoplocephalus stephensi, Austrelaps superbus and Notechis scutatus: efficacy of tiger snake antivenom. Clin Exp Pharmacol Physiol 30:127–132CrossRefPubMed

Hodgson WC, Wickramaratna JC (2002) The in vitro neuromuscular activity of snake venoms. Clin Exp Pharmacol Physiol 29:807–814

Isbister GK, Maduwage K, Page CB (2014) Antivenom cross neutralisation in a suspected Asian pit viper envenoming causing severe coagulopathy. Toxicon 90:286–290. doi:10.1016/j.toxicon.2014.08.071 CrossRefPubMed

Jorge da Silva N, Sites JW Jr (2001) Phylogeny of South American triad coral snakes (Elapidae: Micrurus) based on molecular characters. Herpetologica 57:1–22

Jorge da Silva N Jr, Aird SD (2001) Prey specificity, comparative lethality and compositional differences of coral snake venoms. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 128:425–456CrossRef

Kornhauser R, Isbister GK, O’Leary MA, Mirtschin P, Dunstan N, Hodgson WC (2013) Cross-neutralisation of the neurotoxic effects of Egyptian cobra venom with commercial tiger snake antivenom. Basic Clin. Pharmacol. Toxicol. 112:138–143CrossRefPubMed

Kuruppu S, Robinson S, Hodgson WC, Fry BG (2007) The in vitro neurotoxic and myotoxic effects of the venom from the Suta genus (curl snakes) of elapid snakes. Basic Clin. Pharmacol. Toxicol. 101:407–410CrossRefPubMed

Lee MSY, Sanders KL, King B, Palci A (2016) Diversification rates and phenotypic evolution in venomous snakes (Elapidae). Royal Society Open Science 3(1):150277CrossRefPubMedPubMedCentral

Lomonte B, Rey-Suárez P, Fernández J, Sasa M, Pla D, Vargas N, Bénard-Valle M, Sanz L, Correa-Netto C, Núñez V, Alape-Girón A, Alagón A, Gutiérrez JM, Calvete JJ (2016a) Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses. Toxicon 122:7–25. doi:10.1016/j.toxicon.2016.09.008 CrossRefPubMed

Lomonte B, Sasa M, Rey-Suárez P, Bryan W, Gutiérrez JM (2016b) Venom of the coral snake Micrurus clarki: proteomic profile, toxicity, immunological cross-neutralization, and characterization of a three-finger toxin. Toxins 8(5). doi:10.3390/toxins8050138

Lumsden NG, Fry BG, Kini RM, Hodgson WC (2004a) In vitro neuromuscular activity of ‘colubrid’ venoms: clinical and evolutionary implications. Toxicon 43:819–827CrossRefPubMed

Lumsden NG, Fry BG, Ventura S, Kini RM, Hodgson WC (2004b) The in vitro and in vivo pharmacological activity of Boiga dendrophila (mangrove catsnake) venom. Auton Autacoid Pharmacol 24:107–113CrossRefPubMed

Lumsden NG, Fry BG, Ventura S, Kini RM, Hodgson WC (2005a) Pharmacological characterisation of a neurotoxin from the venom of Boiga dendrophila (mangrove catsnake). Toxicon 45:329–334CrossRefPubMed

Lumsden NG, Ventura S, Dauer R, Hodgson WC (2005b) A biochemical and pharmacological examination of Rhamphiophis oxyrhynchus (rufous beaked snake) venom. Toxicon 45:219–231CrossRefPubMed

Manock SR, Suarez G, Graham D, Avila-Aguero ML, Warrell DA (2008) Neurotoxic envenoming by South American coral snake (Micrurus lemniscatus helleri): case report from eastern Ecuador and review. Trans R Soc Trop Med Hyg 102:1127–1132CrossRefPubMed

Morgan DL, Borys DJ, Stanford R, Kjar D, Tobleman W (2007) Texas coral snake (Micrurus tener) bites. South Med J 100:15–156CrossRef

Orme D, Freckleton R, Thomas G, Petzoldt T, Fritz S, Isaac N, Pearse W (2015) Caper: comparative analyses of phylogenetics and evolution in R, R package version 0.5.2, 2015. Available online: https://CRAN.R-project.org/package=caper. Accessed on 10 Feb 2017)

Paradis E, Claude J, Strimmer K (2004) APE: analyses of phylogenetics and evolution in R language. Bioinformatics 20:289–290

Peterson ME (2006) Snake bite: coral snakes. Clinical Techniques in Small Animal Practice 21:183–186CrossRefPubMed

Pycroft K, Fry BG, Isbister GK, Kuruppu K, Lawrence J, Smith AI, Hodgson WC (2012) Toxinology of venoms from five Australian lesser known elapid snakes. Basic Clin Pharmacol Toxicol 111:268–274CrossRefPubMed

R-Core-Team (2011) R: A language and environment for statistical computing. R Foundation for Statistical Computing. Available online: https://www.R-project.org/

Revell LJ (2012) Phytools: an R package for phylogenetic comparative biology (and other things). Methods in Ecology and Evolution 3:217–223

Rey-Suarez P, Nunez V, Fernandez J, Lomonte B (2016) Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: proteome, toxicity, and cross-neutralization by antivenom. J Proteome 136:262–273CrossRef

Rojas G, Jiménez JM, Gutiérrez JM (1994) Caprylic acid fractionation of hyperimmune horse plasma: description of a simple procedure for antivenom production. Toxicon 32:351–363CrossRefPubMed

Roze JA (1996) Coral snakes of the Americas: biology, identification, and venoms. Krieger Publishing Company

Sánchez EE, Lopez-Johnston JC, Rodríguez-Acosta A, & Pérez JC (2008) Neutralization of two North American coral snake venoms with United States and Mexican antivenom. Toxicon 51(2):297–303. doi:10.1016/j.toxicon.2007.10.004

Silva A, Hodgson WC, Isbister GK (2016) Cross-neutralisation of in vitro neurotoxicity of Asian and Australian snake neurotoxins and venoms by different antivenoms. Toxins 8(10):1–18. doi:10.3390/toxins8100302 CrossRef

Symonds MRE, Blomberg SP (2014) A primer on phylogenetic generalised least squares (PGLS). In: Modern phylogenetic comparative methods and their application in evolutionary biology: concepts and practice (ed. LZ Garamszegi). Springer, Berlin, Chapter 5, pp 105–130

Tanaka GD, Furtado MDFD, Portaro FCV, Sant’Anna OA, Tambourgi DV (2010) Diversity of Micrurus snake species related to their venom toxic effects and the prospective of antivenom neutralization. PLoS Negl Trop Dis 4(3):e622. doi:10.1371/journal.pntd.0000622 CrossRefPubMedPubMedCentral

Utkin Y, Sunagar K, Jackson TNW, Reeks T, Fry BG (2015) Three-finger toxins (3FTxs). In: Fry BG (ed) Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. Oxford University Press, New York, pp 215–227

Vergara I, Pedraza-Escalona M, Paniagua D, Restano-Cassulini R, Zamudio F, Batista CVF, Possani L, Alagón A (2014) Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A₂. J Proteome 105:295–306

Vital-Brazil O (1987) Coral snake venoms: mode of action and pathophysiology of experimental envenomation. Rev Inst Med Trop Sao Paulo 29:119–126

WHO (2010) WHO guidelines for the production, control and regulation of snake antivenom immunoglobulins. WHO, Geneva http://apps.who.int/bloodproducts/snakeantivenoms/database

Wickramaratna JC, Hodgson WC (2001) A pharmacological examination of venoms from three species of death adder (Acanthopis antarcticus, Acanthopis praelongus and Acanthopis pyrrhus). Toxicon 39:209–216

Wisniewski MS, Hill RE, Havey JM, Bogdan GM, Dart RC (2003) Australian tiger snake (Notechis scutatus) and mexican coral snake (Micruris species) antivenoms prevent death from United States coral snake (Micrurus fulvius fulvius) venom in a mouse model. J Toxicol Clin Toxicol 41(1):7–10. doi:10.1081/clt-120018264 CrossRefPubMed

Wood A, Schauben J, Thundiyil J, Kunisaki T, Sollee D, Lewis-Younger C, Bernstein J, Weisman R (2013) Review of eastern coral snake (Micrurus fulvius fulvius) exposures managed by the Florida Poison Information Center Network: 1998–2010. Clin Toxicol 51:783–788CrossRef

Titel: The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom
verfasst von: Daryl C. Yang
James Dobson
Chip Cochran
Daniel Dashevsky
Kevin Arbuckle
Melisa Benard
Leslie Boyer
Alejandro Alagón
Iwan Hendrikx
Wayne C. Hodgson
Bryan G. Fry
Publikationsdatum: 01.10.2017
Verlag: Springer US
Erschienen in: Neurotoxicity Research / Ausgabe 3/2017
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-017-9771-4

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