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Journal of Cancer Research and Clinical Oncology

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08.11.2019 | Original Article – Cancer Research

The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients

verfasst von: Bing-Yen Wang, Jing-Yang Huang, Heng-Chung Chen, Ching-Hsiung Lin, Sheng-Hao Lin, Wei-Heng Hung, Ya-Fu Cheng

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 1/2020

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Abstract

Background

There are several studies comparing the difference between adenocarcinoma (AC) and squamous cell carcinoma (SqCC) of lung cancer. However, seldom studies compare the different overall survival (OS) between AC and SqCC at same clinical or pathological stage. The aim of the study was to investigate the 5-year OS between AC and SqCC groups.

Methods

Data were obtained from the Taiwan Society of Cancer Registry. There were 48,296 non-small cell lung cancer (NSCLC) patients analyzed between 2009 and 2014 in this retrospective study. We analyzed both the AC and SqCC groups by age, gender, smoking status, Charlson co-morbidity index (CCI) score, clinical TNM stage, pathological stage, tumor location, histologic grade, pleura invasion, performance status, treatment, stage-specific 5-year OS rate in each clinical stage I–IV and causes of death. We used propensity score matching to reduce the bias.

Results

The AC and SqCC groups are significantly different in age, gender, smoking status, CCI score, clinical TNM stage, pathological stage, tumor location, histologic grade, pleura invasion, performance status, treatment, stage-specific 5-year OS rate in each clinical stage and causes of death (p < 0.0001). The stage-specific 5-year OS rates between AC and SqCC were 79% vs. 47% in stage I; 50% vs. 32% in stage II; 27% vs. 13% in stage III; 6% vs. 2% in stage IV, respectively (all p values < 0.0001).

Conclusions

AC and SqCC have significantly different outcomes in lung cancer. We suggest that these two different cancers should be analyzed separately to provide more precise outcomes in the future.

Asamura H, Goya T, Koshiishi Y et al (2008) A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers. J Thorac Oncol 3:46–52CrossRef

Berardi R, Brunelli A, Tamburrano T et al (2005) Perioperative anemia and blood transfusions as prognostic factors in patients undergoing resection for non-small cell lung cancers. Lung Cancer 49:371–376CrossRef

Buccheri G, Barberis P, Delfino MS (1991) Diagnostic, morphologic, and histopathologic correlates in bronchogenic carcinoma. A review of 1,045 bronchoscopic examinations. Chest 99:809–814CrossRef

Chang JW, Asamura H, Kawachi R et al (2009) Gender difference in survival of resected non-small cell lung cancer: histology-related phenomenon? J Thorac Cardiovasc Surg 137:807–812CrossRef

Chansky K, Sculier JP, Crowley JJ et al (2009) The International Association for the Study of Lung Cancer Staging Project: prognostic factors and pathologic TNM stage in surgically managed non-small cell lung cancer. J Thorac Oncol 4:792–801CrossRef

Chow WH, Blot WJ, Vaughan TL et al (1998) Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst 90:150–155CrossRef

Cook MB, Kamangar F, Whiteman DC et al (2010) Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium. J Natl Cancer Inst 102:1344–1353CrossRef

de Perrot M, Licker M, Bouchardy C et al (2000) Sex differences in presentation, management, and prognosis of patients with non-small cell lung carcinoma. J Thorac Cardiovasc Surg 119:21–26CrossRef

Devesa SS, Bray F, Vizcaino AP et al (2005) International lung cancer trends by histologic type: male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer 117:294–299CrossRef

Ettinger DS, Wood DE, Aisner DL et al (2017) Non-Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 15:504–535CrossRef

Ferguson MK, Wang J, Hoffman PC et al (2000) Sex-associated differences in survival of patients undergoing resection for lung cancer. Ann Thorac Surg 69:245–249 (Discussion 249-250) CrossRef

Foegle J, Hedelin G, Lebitasy MP et al (2007) Specific features of non-small cell lung cancer in women: a retrospective study of 1738 cases diagnosed in Bas-Rhin between 1982 and 1997. J Thorac Oncol 2:466–474CrossRef

Hitchman SC, Fong GT (2011) Gender empowerment and female-to-male smoking prevalence ratios. Bull World Health Organ 89:195–202CrossRef

Howlader NNA, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2014, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2014/, based on November 2016 SEER data submission, posted to the SEER web site,. April 2017

Hsu LH, Chu NM, Liu CC et al (2009) Sex-associated differences in non-small cell lung cancer in the new era: is gender an independent prognostic factor? Lung Cancer 66:262–267CrossRef

Jemal A, Clegg LX, Ward E et al (2004) Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survival. Cancer 101:3–27CrossRef

Johansson L, Albin M, Jakobsson K et al (1992) Histological type of lung carcinoma in asbestos cement workers and matched controls. Br J Ind Med 49:626–630PubMedPubMedCentral

Kawaguchi T, Takada M, Kubo A et al (2010) Performance status and smoking status are independent favorable prognostic factors for survival in non-small cell lung cancer: a comprehensive analysis of 26,957 patients with NSCLC. J Thorac Oncol 5:620–630CrossRef

Lagergren J, Bergstrom R, Nyren O (1999) Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann Intern Med 130:883–890CrossRef

Lewis DR, Check DP, Caporaso NE et al (2014) US lung cancer trends by histologic type. Cancer 120:2883–2892CrossRef

Lopez Guerra JL, Gomez DR, Lin SH et al (2013) Risk factors for local and regional recurrence in patients with resected N0-N1 non-small-cell lung cancer, with implications for patient selection for adjuvant radiation therapy. Ann Oncol 24:67–74CrossRef

Lortet-Tieulent J, Soerjomataram I, Ferlay J et al (2014) International trends in lung cancer incidence by histological subtype: adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer 84:13–22CrossRef

Meza R, Meernik C, Jeon J et al (2015) Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010. PLoS One 10:e0121323CrossRef

Paris C, Benichou J, Saunier F et al (2003) Smoking status, occupational asbestos exposure and bronchial location of lung cancer. Lung Cancer 40:17–24CrossRef

Pesch B, Kendzia B, Gustavsson P et al (2012) Cigarette smoking and lung cancer–relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer 131:1210–1219CrossRef

Pfannschmidt J, Muley T, Bulzebruck H et al (2007) Prognostic assessment after surgical resection for non-small cell lung cancer: experiences in 2083 patients. Lung Cancer 55:371–377CrossRef

Puri V, Garg N, Engelhardt EE et al (2010) Tumor location is not an independent prognostic factor in early stage non-small cell lung cancer. Ann Thorac Surg 89:1053–1059CrossRef

Rice TW, Blackstone EH, Rusch VW (2010) 7th edition of the AJCC Cancer Staging Manual: esophagus and esophagogastric junction. Ann Surg Oncol 17:1721–1724CrossRef

Sakurai H, Asamura H, Goya T et al (2010) Survival differences by gender for resected non-small cell lung cancer: a retrospective analysis of 12,509 cases in a Japanese Lung Cancer Registry study. J Thorac Oncol 5:1594–1601CrossRef

Siewert JR, Stein HJ, Feith M et al (2001) Histologic tumor type is an independent prognostic parameter in esophageal cancer: lessons from more than 1,000 consecutive resections at a single center in the Western world. Ann Surg 234:360–367 (Discussion 368-369) CrossRef

Strand TE, Rostad H, Moller B et al (2006) Survival after resection for primary lung cancer: a population based study of 3211 resected patients. Thorax 61:710–715CrossRef

Torre LA, Bray F, Siegel RL et al (2015) Global cancer statistics, 2012. CA Cancer J Clin 65:87–108CrossRef

Toyoda Y, Nakayama T, Ioka A et al (2008) Trends in lung cancer incidence by histological type in Osaka, Japan. Jpn J Clin Oncol 38:534–539CrossRef

Travis WD, Lubin J, Ries L et al (1996) United States lung carcinoma incidence trends: declining for most histologic types among males, increasing among females. Cancer 77:2464–2470CrossRef

Wang BY, Huang JY, Cheng CY et al (2013) Lung cancer and prognosis in taiwan: a population-based cancer registry. J Thorac Oncol 8:1128–1135 (Official publication of the International Association for the Study of Lung Cancer) CrossRef

Wisnivesky JP, Halm EA (2007) Sex differences in lung cancer survival: do tumors behave differently in elderly women? J Clin Oncol 25:1705–1712CrossRef

Wisnivesky JP, Henschke C, McGinn T et al (2005) Prognosis of Stage II non-small cell lung cancer according to tumor and nodal status at diagnosis. Lung Cancer 49:181–186CrossRef

Youlden DR, Cramb SM, Baade PD (2008) The International Epidemiology of Lung Cancer: geographical distribution and secular trends. J Thorac Oncol 3:819–831CrossRef

Titel: The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients
verfasst von: Bing-Yen Wang
Jing-Yang Huang
Heng-Chung Chen
Ching-Hsiung Lin
Sheng-Hao Lin
Wei-Heng Hung
Ya-Fu Cheng
Publikationsdatum: 08.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 1/2020
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-019-03079-8

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The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients