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01.12.2018 | Research | Ausgabe 1/2018 Open Access

Virology Journal 1/2018

The detection of 3 ambiguous type 2 vaccine-derived polioviruses (VDPV2s) in Uganda

Zeitschrift:
Virology Journal > Ausgabe 1/2018
Autoren:
Mary Bridget Nanteza, Barnabas Bakamutumaho, Annet Kisakye, Prossy Namuwulya, Henry Bukenya, Edson Katushabe, Josephine Bwogi, Charles Rutebarika Byabamazima, Raffaella Williams, Nicksy Gumede
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12985-018-0990-y) contains supplementary material, which is available to authorized users.

Abstract

Background

The Oral Polio Vaccine (OPV or Sabin) is genetically unstable and may mutate to form vaccine-derived polioviruses (VDPVs).

Methods

In 2014, two VDPVs type 2 were identified during routine surveillance of acute flaccid paralysis (AFP) cases. Consequently, a retrospective VDPV survey was conducted to ensure that there was no circulating VDPV in the country. All Sabin poliovirus isolates identified in Uganda 6 months before and 6 months after were re-screened; Sabin 1 and 3 polioviruses were re-screened for Sabin 2 and Sabin 2 polioviruses were re-screened for VDPVs type 2. The Poliovirus rRT-PCR ITD/VDPV 4.0 assay and sequencing were used respectively.

Results

The first two VDPVs type2 were identified in Eastern Uganda and the third was identified during the survey from South-western Uganda. These regions had low OPV coverage and poor AFP surveillance indicators.

Conclusion

The retrospective VDPV survey was a useful strategy to screen for VDPVs more exhaustively. Supplementary surveillance methods need to be encouraged.
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