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01.12.2018 | Review | Ausgabe 1/2018 Open Access

Journal of Experimental & Clinical Cancer Research 1/2018

The dysregulation of tRNAs and tRNA derivatives in cancer

Zeitschrift:
Journal of Experimental & Clinical Cancer Research > Ausgabe 1/2018
Autoren:
Shi-qiong Huang, Bao Sun, Zong-ping Xiong, Yan Shu, Hong-hao Zhou, Wei Zhang, Jing Xiong, Qing Li

Abstract

Transfer RNAs (tRNAs), traditionally considered to participate in protein translation, were interspersed in the entire genome. Recent studies suggested that dysregulation was observed in not only tRNAs, but also tRNA derivatives generated by the specific cleavage of pre- and mature tRNAs in the progression of cancer. Accumulating evidence had identified that certain tRNAs and tRNA derivatives were involved in proliferation, metastasis and invasiveness of cancer cell, as well as tumor growth and angiogenesis in several malignant human tumors. This paper reviews the importance of the dysregulation of tRNAs and tRNA derivatives during the development of cancer, such as breast cancer, lung cancer, and melanoma, aiming at a better understanding of the tumorigenesis and providing new ideas for the treatment of these cancers.
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