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International Journal of Clinical Oncology

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22.12.2016 | Review Article

The effect of consolidation chemotherapy after concurrent chemoradiotherapy on the survival of patients with locally advanced non-small cell lung cancer: a meta-analysis

verfasst von: Xinshuai Wang, Xuezhen Ding, Dejiu Kong, Li Zhang, Yibo Guo, Jing Ren, Xiaochen Hu, Junqiang Yang, Shegan Gao

Erschienen in: International Journal of Clinical Oncology | Ausgabe 2/2017

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Abstract

Whether consolidation chemotherapy (CCT) after chemoradiotherapy (CRT) helps in the treatment of locally advanced non-small cell lung cancer (LA-NSCLC) is controversial. The aim of this meta-analysis was to evaluate the impact of CCT on overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicities in patients with inoperable LA-NSCLC. PubMed, Embase, The Cochrane Library, WanFang, VIP, and CNKI were searched to identify any relevant publications. After screening the literature and completing quality assessment and data extraction, the meta-analysis was performed using RevMan5.3 software. Ultimately, 5 eligible studies with a total of 1036 patients were selected for the present meta-analysis. The results of the analysis indicated that treatment of LA-NSCLC patients with CRT followed by CCT improved OS (pooled HR 0.85; 95% CI 0.73–0.99; P = 0.03), but did not improve PFS (pooled HR 0.78; 95% CI 0.60–1.02; P = 0.07) and ORR (P = 0.26). Although it could increase the risk of grade ≥3 infection (P = 0.04), it may not increase the risk of grade ≥3 radiation pneumonitis (P = 0.09) during the CCT period. CCT after concurrent CRT may provide additional benefits in the treatment of LA-NSCLC. Although this therapeutic strategy did not prolong PFS, further assessment is warranted.

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Titel: The effect of consolidation chemotherapy after concurrent chemoradiotherapy on the survival of patients with locally advanced non-small cell lung cancer: a meta-analysis
verfasst von: Xinshuai Wang
Xuezhen Ding
Dejiu Kong
Li Zhang
Yibo Guo
Jing Ren
Xiaochen Hu
Junqiang Yang
Shegan Gao
Publikationsdatum: 22.12.2016
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 2/2017
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-016-1074-x

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