Background
Methods
Search strategy
Eligibility criteria
Data extraction
Statistical analysis
Results
Study characteristics
Authors | Year | Type of study | Country | Study population | Age | Sample size | Type of diabetes | Measurement of association | Controlled variables |
---|---|---|---|---|---|---|---|---|---|
Al Hilli. M, et al. [16] | 2015 | Cohort | USA | database for the records of all patients who underwent primary surgical intervention for EC, from January 1, 1999, through December 31, 2008. | All age | 1303 | Diabetes | HR: 1.01; % 95 CI (0.72,1.42) | Age, BMI |
Friberg. E, et al. [17] | 2007 | Cohort | Sweden | Exposed group: 1628 women with self-reported DM or DM from national inpatient register Comparison group: 35145 women without self-reported DM or DM from national inpatient register | 50–83 | 36,773 | Diabetes | RR: 1.94; % 95 CI(1.23,3.08) | Age, BMI, total physical activity |
Anderson. K, et al.[5] | 2001 | Cohort | USA | Exposed group: 1325 women with self-reported DM Comparison group: 23150 women without self-reported DM | 55–69 | 24,475 | Diabetes | RR: 1.43; % 95 CI(0.98,2.09) | Age, BMI, BMI2, WHR, ovulatory span, gravidity, PMH, menstrual irregularities, hypertension |
Lindemann. K, et al. [6] | 2008 | Cohort | Norway | Norwegian women during 15.7 years of follow-up. | All age | 36,761 | Diabetes | RR: 3.84 (% 95 CI: 1.92,5.11) | Age |
Folsom. A, et al. [20] | 2004 | Cohort | USA | Exposed group: 42 women with self-reported DM and an endometrial cancer diagnosis Comparison group: 373 women with self-reported DM and an endometrial cancer diagnosis | 55–69 | 415 | Diabetes | RR: 2.38 (% 95 CI: 1.05,5.37) | Age, extent of endometrial cancer at diagnosis |
Luo. J, et al. [4] | 2014 | Cohort | USA | Women’s Health Initiative | 50–79 | 88,107 | Diabetes | HR: 1.16 (% 95 CI: 0.90,1.48) | Age, BMI |
Terry. P, et al. [21] | 1999 | Cohort | Sweden | Exposed group: 142 women with self-reported DM Comparison group: 10012 women without self-reported DM | 42–81 | 10,154 | Diabetes | RR: 1.60 (% 95 CI: 0.20,11.30) | Age, physical activity, weight, parity |
Coughlin. S, et al. [19] | 2004 | Cohort | USA | Exposed group: 33 women with self-reported DM Comparison group: 448 women without self-reported DM | > 30 | 481 | Diabetes | RR: 1.33 (% 95 CI: 0.92,1.90) | Age, race, education, BMI, smoking, alcohol, red meat, citrus fruit and juice, vegetables, physical activity, PMH, parity, age at menarche, age at first live birth, menopausal status, OC |
esLambe. M, et al. [18] | 2011 | Cohort | Sweden | individuals that took part in routine health checkups and primary care patients referred for laboratory testing | All age | 230,737 | Diabetes | HR: 1.46(% 95 CI 1.09,1.96 | Age |
Authors | Year | Country | Control subjects (selection methods) | Age | Sample size | Type of diabetes | Measurement of association | Controlled variables |
---|---|---|---|---|---|---|---|---|
Weiderpass. E, et al. [33] | 2000 | Sweden | Control women were randomly selected from a continuously updated population register that includes all residents. | 50–74 | Case(709) | Diabetes | OR: 1.7 (% 95 CI: 1.2,2.3) | Age, age at menarche, parity, age at last birth, age at menopause, smoking, OC, PMH, BMI |
Control(3368) | ||||||||
T(4077) | ||||||||
Shoff. SM, et al. [30] | 1998 | USA | Community controls were selected randomly from lists | 40–79 | Case(723) | Diabetes | OR: 1.10 (% 95 CI: 0.66,1.86) | Age, BMI, smoking, PMH, parity, education |
Control(2291) | ||||||||
T(3014) | ||||||||
Lucenteforte. E, et al. [25] | 2007 | Italy | Controls women admitted to the same network of hospitals | 18–79 | Case(777) | Diabetes | OR: 2.0 (% 95 CI: 1.4,2.9) | Age, year of interview, study center, education, parity, menopausal status, OC and HRT use |
Control(1550) | ||||||||
T(2327) | ||||||||
Friedenreich. CM, et al. [23] | 2011 | Canada | Controls selected from the Alberta Cancer Registry | 30–79 | Case(515) | Diabetes | OR: 1.31(95% CI: 1.03,1.67) | Age, parity, education, age at menarche, hormone therapy, age at menopause, history of Type 2 diabetes, hormone contraception, oral and non-oral hormone use, history of angina, history of stroke, history of thrombosis, smoking and alcohol consumption |
Control(962) | ||||||||
T(1447) | ||||||||
Saltzman. BS, et al. [29] | 2007 | USA | Controls selected from Women’s Contraceptive and Reproductive Experiences (CARE) breast cancer study | 45–74 | Case(1303) | Diabetes | OR: 1.7(% 95 (CI: 1.2, 2.3) | Country, age, reference year, body mass index, and menopausal hormone use |
Control(1779) | ||||||||
T(3082) | ||||||||
Parazzini. F, et al. [26] | 1999 | Italy | Controls selected from same network of hospitals where cases had been identified. | 28–74 | Case(752) | Diabetes | OR: 3.1 (% 95 CI: 2.3,4.2) | Age, calendar year, education, BMI, parity, OC, PMH, age at menopause, hypertension, smoking |
Control(2606) | ||||||||
T(3358) | ||||||||
Wartko. PD, et al. [32] | 2017 | USA | Control were randomly selected from all other women with delivery records from 1987 to 2013. | All age | Case(593) | Diabetes | OR: 1.80 (% 95 CI: 1.22,2.65) | Race/ethnicity, year of delivery, maternal age at delivery, and body mass index |
Control(5743) | ||||||||
T(6336) | ||||||||
Soliman. PT, et al. [31] | 2006 | USA | Controls patient samples were obtained through a low-risk cancer screening program | All age | Case(117) | Diabetes | OR: 1.87 (%95, CI: 0.77,4.54) | Lower serum adiponectin level, age, BMI, and hypertension |
Control(238) | ||||||||
T(355) | ||||||||
Rubin. GL, et al.[27] | 1990 | USA | population controls, matched for place of residence and age | 20–54 | Case(196) | Diabetes | OR: 1.80 (%95, CI: 0.90,3.60) | Age |
Control(986) | ||||||||
T(1182) | ||||||||
Brinton. L A, et al. [22] | 1992 | USA | Population controls random digit dialing for younger controls and health care financing administration for older controls, older controls were matched on age, race and zip code | 20–74 | Case(405) | Diabetes | OR: 1.95 (%95, CI: 1.10,3.60) | Age, education, number of births, weight, OC, PMH |
Control(279) | ||||||||
T(684) | ||||||||
Inoue. M, et al. [24] | 1994 | Japan | hospital control who underwent hysterectomy due to benign gynecological tumors, matched on year of admittance to hospital and age | 22–79 | Case(143) | Diabetes | OR: 7.75 (%95, CI: 1.52,40.0) | Age, parity, cancer history, hypertension, obesity |
Control(143) | ||||||||
T(286) | ||||||||
Weiss. J M, et al. [34] | 2006 | USA | Population that matched on age | 45–75 | Case(1281) | Diabetes | OR: 1.58 (%95, CI: 1.20,2.07) | Age, PMH, BMI, county, referent year, tumors aggressiveness |
Control(1779) | ||||||||
T(3060) | ||||||||
Salazar. M E, et al.[28] | 2000 | Mexico | Hospital, from primary health center i.e. outpatient, matched on age | NA | Case(85) | Diabetes | OR: 3.60 (%95, CI: 1.70,7.40) | Age, an ovulatory index, smoking, physical activity, menopausal status, hypertension, BMI |
Control(668) | ||||||||
T(753) |
Subgroup analysis
Subgroup | Number of studies | Summery Relative Risk (95% CI) | Between studies | Between subgroups | |||
---|---|---|---|---|---|---|---|
I2 | P heterogeneity | Q | Q | P heterogeneity | |||
Study design | |||||||
Cohort | 8 | 1.52 (1.16–2.00) | 70.7% | 0.001 | 3.03 | 5.79 | 0.001a |
Case-Control | 5 | 2.31 (1.81–2.96) | 22.7% | 0.270 | 6.69 | ||
Population-based | 7 | 1.55 (1.37–1.75) | 0.0% | 0.461 | 6.88 | 4.95 | 0.034b |
Hospital-based | 2 | 4.10 (2.09–8.01) | 0.0% | 0.402 | 4.12 | ||
Adjustment | 3 | 1.88 (1.48–2.38) | 81.9% | 0.004 | 5.21 | 8.78 | 0.045 |
Age | 13 | 1.62 (1.34–1.97) | 71.0% | 0.0001 | 4.14 | ||
BMI | 3 | 2.45 (1.14–5.26) | 21.0% | 0.021 | 2.53 | ||
Weight | 4 | 1.89 (1.22–2.94) | 50.6% | 0.108 | 6.08 | ||
Physical Activity |