nach oben

Calcified Tissue International

Erschienen in:

05.09.2019 | Original Research

The Effect of Dried Beancurd on Bone Mineral Density in Postmenopausal Chinese Women: A 2-Year Randomized Controlled Trial

verfasst von: Lei Li, Meijun Sun, Jianping Sun, Hangru Kong, Wenwen Zhong, Hong Wang

Erschienen in: Calcified Tissue International | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

Soy foods contain several components such as isoflavones, calcium and protein that potentially modulate bone turnover and increase bone mineral density (BMD) in postmenopausal women. The study is to evaluate the effect of dried beancurd supplementation on skeletal health in postmenopausal Chinese women. Three hundred postmenopausal women aged 50–65 years were assigned into two groups, receiving 100 g dried beancurd or rice cake a day for 2 years. BMD at the lumbar spine and right proximal femur were measured with a dual-energy X-ray absorptiometry. The bone turnover biomarkers of serum alkaline phosphatase (ALP), bone Gla protein (BGP) and urinary N-telopeptide cross-links of collagen normalized for creatinine (NTX/CRT) were also determined. Serum isoflavone concentration was analyzed by high performance liquid chromatography. The 2-year dried beancurd supplementation generated a significant increase in lumbar spine BMD. An obvious decrease was found in urinary NTX/CRT, and a significant increase was detected in serum isoflavone concentration. The dried beancurd supplementation had no effect on changes of right proximal femur BMD and concentrations of serum ALP and BGP. Daily supplementation of dried beancurd could increase BMD of lumbar spine, but does not slow bone loss at right proximal femur in postmenopausal Chinese women.

Nur mit Berechtigung zugänglich

Gallagher JC (1990) The pathogenesis of osteoporosis. Bone Mineral 9(3):215–227. https://doi.org/10.1016/0169-6009(90)90039-I CrossRefPubMed

National Health Commission of the People’s Republic of China (2018) The epidemiological investigation of osteoporosis in China. http://www.nhc.gov.cn/wjw/zcjd/201810/4988546cfa1040db86c1815d3dad7a2b.shtml. Accessed 20 Oct 2018

Cauley JA, Zmuda JM, Ensrud KE, Bauer DC, Ettinger B (2001) Timing of estrogen replacement therapy for optimal osteoporosis prevention. J Clin Endocrinol Metab 86(12):5700–5705. https://doi.org/10.1210/jcem.86.12.8079 CrossRefPubMed

Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA 288(3):321–333. https://doi.org/10.1001/jama.288.3.321 CrossRefPubMed

Ghanem K (2007) Beneficial effects of soybean protein and isoflavone extract supplementation on bone density and plasma lipids in females rats. Pol J Food Nutr Sci 57(1):103–108

Arjmandi BH, Alekel L, Hollis BW, Amin D, Stacewicz-Sapuntzakis M, Guo P, Kukreja SC (1996) Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr 126(1):161–167. https://doi.org/10.1093/jn/126.1.161 CrossRefPubMed

AlAnazi AF, Qureshi VF, Javaid K, Qureshi S (2011) Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: an overview. J Nat Sci Biol Med 2(2):154–163. https://doi.org/10.4103/0976-9668.92322 CrossRef

Ho SC, Woo J, Lam S, Chen Y, Sham A, Lau J (2003) Soy protein consumption and bone mass in early postmenopausal Chinese women. Osteoporos Int 14(10):835–842. https://doi.org/10.1007/s00198-003-1453-9 CrossRefPubMed

Alekel DL, Germain AS, Peterson CT, Hanson KB, Stewart JW, Toda T (2000) Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 72(3):844–852. https://doi.org/10.1093/ajcn/72.3.844 CrossRefPubMed

10.

Brink E, Coxam V, Robins S, Wahala K, Cassidy A, Branca F, Invest P (2008) Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am J Clin Nutr 87(3):761–770. https://doi.org/10.1093/ajcn/87.3.761 CrossRefPubMed

11.

Tai TY, Tsai KS, Tu ST, Wu JS, Chang CI, Chen CL, Shaw NS, Peng HY, Wang SY, Wu CH (2012) The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study. Osteoporos Int 23(5):1571–1580. https://doi.org/10.1007/s00198-011-1750-7 CrossRefPubMed

12.

Kenny AM, Mangano KM, Abourizk RH, Bruno RS, Anamani DE, Kleppinger A, Walsh SJ, Prestwood KM, Kerstetter JE (2009) Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Am J Clin Nutr 90(1):234–242. https://doi.org/10.3945/ajcn.2009.27600 CrossRefPubMedPubMedCentral

13.

Zhang XL, Shu XO, Li HL, Yang G, Li Q, Gao YT, Zheng W (2005) Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 165(16):1890–1895. https://doi.org/10.1001/archinte.165.16.1890 CrossRefPubMed

14.

Koh WP, Wu AH, Wang RW, Ang LW, Heng D, Yuan JM, Yu MC (2009) Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study. Am J Epidemiol 170(7):901–909. https://doi.org/10.1093/aje/kwp220 CrossRefPubMedPubMedCentral

15.

Wu Y, Liu J, Xing S, Xu R, Zhang Z, Wang Y (2002) Comparative study on two different dosages of conjugated equine estrogen continuously combined with medroxyprogesterone in prevention of postmenopausal osteoporosis. Chin J Obstet Gynecol 37(5):267–270

16.

Pines A, Katchman H, Villa Y, Mijatovic V, Dotan I, Levo Y, Ayalon D (2010) The effect of various hormonal preparations and calcium supplementation on bone mass in early menopause. Is there a predictive value for the initial bone density and body weight? J Intern Med 246(4):357–361. https://doi.org/10.1046/j.1365-2796.1999.00578.x CrossRef

17.

Craft NE, Mitchell T (2007) Comparison of plasma isoflavone extraction. FASEB J 21(5):A733–A733. https://doi.org/10.1096/fasebj.21.5.A733-a CrossRef

18.

Yang Y, Wang G, Pan X (2009) Chinese food composition. Peking University Medical Press, Beijing

19.

Somekawa Y, Chiguchi M, Ishibashi T, Aso T (2001) Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Am J Obstet Gynecol 97(1):109–115. https://doi.org/10.1097/00006250-200101000-00022 CrossRef

20.

Mei J, Yeung SS, Kung AW (2001) High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocr Metab 86(11):5217–5221. https://doi.org/10.1210/jcem.86.11.8040 CrossRefPubMed

21.

Kritz-Silverstein D, Goodman-Gruen DL (2002) Usual dietary isoflavone intake, bone mineral density, and bone metabolism in postmenopausal women. J Womens Health Gend Based Med 11(1):69–78. https://doi.org/10.1089/152460902753473480 CrossRefPubMed

22.

Taku K, Melby MK, Kurzer MS, Mizuno S, Watanabe S, Ishimi Y (2010) Effects of soy isoflavone supplements on bone turnover markers in menopausal women: systematic review and meta-analysis of randomized controlled trials. Bone 47(2):413–423. https://doi.org/10.1016/j.bone.2010.05.001 CrossRefPubMed

23.

Xin YHY (2006) Influence of daidzein tablets on climacteric syndrome and bone mineral density of women. Chin J Osteoporos 12(02):149–151

24.

Nagata C, Inaba S, Kawakami N, Kakizoe T, Shimizu H (2000) Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men. Nutr Cancer 36(1):14–18. https://doi.org/10.1207/S15327914NC3601_3 CrossRefPubMed

25.

Wangen KE, Duncan AM, Merz-Demlow BE, Xu X, Marcus R, Phipps WR, Kurzer MS (2000) Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women. J Clin Endocrinol Metab 85(9):3043–3048. https://doi.org/10.1210/jcem.85.9.6787 CrossRefPubMed

26.

Hsu CS, Shen WW, Hsueh YM, Yeh SL (2001) Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density. J Reprod Med 46(3):221–226. https://doi.org/10.3109/01674820109049951 CrossRefPubMed

27.

Gallagher JC, Satpathy R, Rafferty K, Haynatzka V (2004) The effect of soy protein isolate on bone metabolism. Menopause 11(3):290–298. https://doi.org/10.1097/01.gme.0000097845.95550.71 CrossRefPubMed

28.

Evans EM, Racette SB, Van Pelt RE, Peterson LR, Villareal DT (2007) Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause 14(3):481–488. https://doi.org/10.1097/01.gme.0000243570.78570.f7 CrossRefPubMedPubMedCentral

29.

Wang RR, Wang JD, Liu EQ (2006) Studies on compound coagulant of tofu. China Condiment 6:25–27

30.

Chinese Nutrition Society (2014) Chinese dietary reference intakes. Science Press, Beijing

31.

Wang MC, Zhao A, Ignatius S, Wang Y, Ting LI, Wang PY, Zhang YM (2017) Calcium intake among Chinese adults in eight cities. Acta Nutrimenta Sinica 39(4):332–336. https://doi.org/10.13325/j.cnki.acta.nutr.sin.2017.04.006 CrossRef

32.

Messina M (2014) Soy foods, isoflavones, and the health of postmenopausal women. Am J Clin Nutr 100(Suppl 1):423S–430S. https://doi.org/10.3945/ajcn.113.071464 CrossRefPubMed

33.

Lydeking-Olsen E, Beck-Jensen JE, Setchell KDR, Holm-Jensen T (2004) Soymilk or progesterone for prevention of bone loss—a 2 year randomized, placebo-controlled trial. Eur J Nutr 43(4):246–257. https://doi.org/10.1007/s00394-004-0497-8 CrossRefPubMed

34.

Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP (2000) Effect of dietary protein on bone loss in elderly men and women: the Framingham osteoporosis study. J Bone Miner Res 15(12):2504–2512. https://doi.org/10.1359/jbmr.2000.15.12.2504 CrossRefPubMed

35.

Munger RG, Cerhan JR, Chiu BC (1999) Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. Am J Clin Nutr 69(1):147–152. https://doi.org/10.1093/ajcn/69.1.147 CrossRefPubMed

36.

Geinoz G, Rapin CH, Rizzoli R, Kraemer R, Buchs B, Slosman D, Michel JP, Bonjour JP (1993) Relationship between bone-mineral density and dietary intakes in the elderly. Osteoporos Int 3(5):242–248. https://doi.org/10.1007/Bf01623827 CrossRefPubMed

37.

Potter SM, Baum JA, Teng HY, Stillman RJ, Shay NF, Erdman JW (1998) Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68(6):1375s–1379sCrossRef

38.

Newton KM, LaCroix AZ, Levy L, Li SS, Qu P, Potter JD, Lampe JW (2006) Soy protein and bone mineral density in older men and women: a randomized trial. Maturitas 55(3):270–277. https://doi.org/10.1016/j.maturitas.2006.04.011 CrossRefPubMed

39.

Chinese Nutrition Society (2008) Dietary guidelines for Chinese (2007). Tibet People’s Publishing House, Tibet

Titel: The Effect of Dried Beancurd on Bone Mineral Density in Postmenopausal Chinese Women: A 2-Year Randomized Controlled Trial
verfasst von: Lei Li
Meijun Sun
Jianping Sun
Hangru Kong
Wenwen Zhong
Hong Wang
Publikationsdatum: 05.09.2019
Verlag: Springer US
Erschienen in: Calcified Tissue International / Ausgabe 6/2019
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-019-00604-2

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

The Effect of Dried Beancurd on Bone Mineral Density in Postmenopausal Chinese Women: A 2-Year Randomized Controlled Trial

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2019

Does Smoking Impair Bone Regeneration in the Dental Alveolar Socket?

Treatment Effects of Bisphosphonates and Denosumab on Survival and Refracture from Real-World Data of Hip-Fractured Patients

Effects of Elevated Parathyroid Hormone Levels on Muscle Health, Postural Stability and Quality of Life in Vitamin D-Insufficient Healthy Women: A Cross-Sectional Study

Understanding Patients’ Perspectives and Educational Needs by Type of Osteoporosis in Men and Women and People with Glucocorticosteroid-Induced Osteoporosis: A Qualitative Study to Improve Disease Management

Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia

Associations of Smoking and Alcohol and Coffee Intake with Fracture and Bone Mineral Density: A Mendelian Randomization Study

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin