Skip to main content
Erschienen in: Urolithiasis 4/2009

01.08.2009 | Original Paper

The effect of EDTA instillations on the rate of development of encrustation and biofilms in Foley catheters

verfasst von: Steven L. Percival, Nora A. Sabbuba, Peter Kite, David J. Stickler

Erschienen in: Urolithiasis | Ausgabe 4/2009

Einloggen, um Zugang zu erhalten

Abstract

The aim of this research was to examine whether a daily instillation of tetra sodium ethylenediaminetetraacetic acid (EDTA) solution could reduce the rate at which encrustation by crystalline Proteus mirabilis biofilms blocks urinary catheters. Sets of three bladder models were fitted with size 14 all-silicone catheters. Tetra sodium EDTA solution was instilled into the catheter following biofilm development. Catheters were examined by digital photography and scanning electron microscopy for evidence of encrustation. The results showed that the mean time to blockage of the control catheters was 45 h for saline, 57 h for water and 67 h for those exposed to daily instillations of the EDTA solution. Statistical analysis confirmed that the mean encrustation rate on the EDTA-treated catheters was significantly lower than on the control-treated devices (P = 0.047). This in vitro study indicates that EDTA may have beneficial effects in reducing the complication of catheter encrustation and blockage by crystalline biofilms.
Literatur
1.
Zurück zum Zitat Cools HJ, Van der Meer JW (1998) Restriction of long-term indwelling urethral catheterisation in the elderly. Br J Urol 58:683–688CrossRef Cools HJ, Van der Meer JW (1998) Restriction of long-term indwelling urethral catheterisation in the elderly. Br J Urol 58:683–688CrossRef
2.
Zurück zum Zitat Kohler-Ockmore J, Feneley RC (1996) Long-term catheterization of the bladder: prevalence and morbidity. Br J Urol 77:347–351PubMed Kohler-Ockmore J, Feneley RC (1996) Long-term catheterization of the bladder: prevalence and morbidity. Br J Urol 77:347–351PubMed
3.
Zurück zum Zitat Mobley HL, Warren JW (1987) Urease-positive bacteriuria and obstruction of long-term urinary catheters. J Clin Microbiol 25:2216–2217PubMed Mobley HL, Warren JW (1987) Urease-positive bacteriuria and obstruction of long-term urinary catheters. J Clin Microbiol 25:2216–2217PubMed
4.
Zurück zum Zitat Kunin CM (1989) Blockage of urinary catheters: role of microorganisms and constituents of the urine on formation of encrustations. J Clin Epidemiol 42:835–842PubMedCrossRef Kunin CM (1989) Blockage of urinary catheters: role of microorganisms and constituents of the urine on formation of encrustations. J Clin Epidemiol 42:835–842PubMedCrossRef
5.
Zurück zum Zitat Stickler DJ, Morris NS, Winters C (1993) Simple physical model to study formation and physiology of biofilms on urethral catheters. Methods Enzymol 310:494–501CrossRef Stickler DJ, Morris NS, Winters C (1993) Simple physical model to study formation and physiology of biofilms on urethral catheters. Methods Enzymol 310:494–501CrossRef
6.
Zurück zum Zitat Stickler DJ, Lear JC, Morris NS et al (2006) Observations on the adherence of Proteus mirabilis onto polymer surfaces. J Appl Microbiol 100:1028–1033PubMedCrossRef Stickler DJ, Lear JC, Morris NS et al (2006) Observations on the adherence of Proteus mirabilis onto polymer surfaces. J Appl Microbiol 100:1028–1033PubMedCrossRef
7.
Zurück zum Zitat Kunin CM (1997) Urinary tract infections: detection, prevention and management, 5th edn. Williams and Wilkins, Baltimore, pp 226–278 Kunin CM (1997) Urinary tract infections: detection, prevention and management, 5th edn. Williams and Wilkins, Baltimore, pp 226–278
8.
Zurück zum Zitat Morris NS, Stickler DJ, Winters C (1997) Which indwelling urethral catheters resist encrustation by Proteus mirabilis biofilms? Br J Urol 80:58–63PubMed Morris NS, Stickler DJ, Winters C (1997) Which indwelling urethral catheters resist encrustation by Proteus mirabilis biofilms? Br J Urol 80:58–63PubMed
9.
Zurück zum Zitat Danese PN (2002) Antibiofilm approaches: prevention of catheter colonization. Chem Biol 9:873–880PubMedCrossRef Danese PN (2002) Antibiofilm approaches: prevention of catheter colonization. Chem Biol 9:873–880PubMedCrossRef
10.
Zurück zum Zitat Raad I, Hachem R, Tcholakian RK et al (2002) Efficacy of minocycline and EDTA lock solution in preventing catheter-related bacteremia, septic phlebitis, and endocarditis in rabbits. Antimicrob Agents Chemother 46:327–332PubMedCrossRef Raad I, Hachem R, Tcholakian RK et al (2002) Efficacy of minocycline and EDTA lock solution in preventing catheter-related bacteremia, septic phlebitis, and endocarditis in rabbits. Antimicrob Agents Chemother 46:327–332PubMedCrossRef
11.
Zurück zum Zitat Kite P, Eastwood K, Sugden S, Percival SL (2004) Use of in vivo-generated biofilms from hemodialysis catheters to test the efficacy of a novel antimicrobial catheter lock for biofilm eradication in vitro. J Clin Microbiol 42:3073–3076PubMedCrossRef Kite P, Eastwood K, Sugden S, Percival SL (2004) Use of in vivo-generated biofilms from hemodialysis catheters to test the efficacy of a novel antimicrobial catheter lock for biofilm eradication in vitro. J Clin Microbiol 42:3073–3076PubMedCrossRef
12.
Zurück zum Zitat Percival SL, Kite P, Eastwood K et al (2005) Tetrasodium EDTA as a novel central venous catheter lock solution against biofilm. Infect Control Hosp Epidemiol 26:515–519PubMedCrossRef Percival SL, Kite P, Eastwood K et al (2005) Tetrasodium EDTA as a novel central venous catheter lock solution against biofilm. Infect Control Hosp Epidemiol 26:515–519PubMedCrossRef
13.
Zurück zum Zitat Devine DA, Percival RS, Wood DJ et al (2007) Inhibition of biofilms associated with dentures and toothbrushes by tetrasodium EDTA. J Appl Microbiol 103:2516–2524PubMedCrossRef Devine DA, Percival RS, Wood DJ et al (2007) Inhibition of biofilms associated with dentures and toothbrushes by tetrasodium EDTA. J Appl Microbiol 103:2516–2524PubMedCrossRef
14.
Zurück zum Zitat Stickler DJ, Morris NS, Winters C (1999) Simple physical model to study formation and physiology of biofilms on urethral catheters. Methods Enzymol 310:494–501PubMedCrossRef Stickler DJ, Morris NS, Winters C (1999) Simple physical model to study formation and physiology of biofilms on urethral catheters. Methods Enzymol 310:494–501PubMedCrossRef
15.
Zurück zum Zitat Stickler D, Ganderton L, King J et al (1993) Proteus mirabilis biofilms and the encrustation of urethral catheters. Urol Res 21:407–411PubMedCrossRef Stickler D, Ganderton L, King J et al (1993) Proteus mirabilis biofilms and the encrustation of urethral catheters. Urol Res 21:407–411PubMedCrossRef
16.
Zurück zum Zitat Stickler DJ (2002) Susceptibility of antibiotic-resistant Gram-negative bacteria to biocides: a perspective from the study of catheter biofilms. J Appl Microbiol 92:163–170CrossRef Stickler DJ (2002) Susceptibility of antibiotic-resistant Gram-negative bacteria to biocides: a perspective from the study of catheter biofilms. J Appl Microbiol 92:163–170CrossRef
17.
Zurück zum Zitat Stickler DJ, Jones GL, Russell AD (2003) Control of encrustation and blockage of Foley catheters. Lancet 361:1435–1437PubMedCrossRef Stickler DJ, Jones GL, Russell AD (2003) Control of encrustation and blockage of Foley catheters. Lancet 361:1435–1437PubMedCrossRef
18.
Zurück zum Zitat Getliffe KA, Hughes SC, Le Claire M (2000) The dissolution of urinary catheter encrustation. BJU Int 85:60–64PubMedCrossRef Getliffe KA, Hughes SC, Le Claire M (2000) The dissolution of urinary catheter encrustation. BJU Int 85:60–64PubMedCrossRef
19.
Zurück zum Zitat Getliffe K (2004) The effect of acidic maintenance solutions on catheter longevity. Nurs Times 100:32–34PubMed Getliffe K (2004) The effect of acidic maintenance solutions on catheter longevity. Nurs Times 100:32–34PubMed
20.
Zurück zum Zitat Getliffe KA (1994) The characteristics and management of patients with recurrent blockage of longterm urinary catheters. J Adv Nurs 20:140–149PubMedCrossRef Getliffe KA (1994) The characteristics and management of patients with recurrent blockage of longterm urinary catheters. J Adv Nurs 20:140–149PubMedCrossRef
21.
Zurück zum Zitat Getliffe KA (1992) Encrustation of urinary catheters in community patients. PhD Thesis. University of Surrey Getliffe KA (1992) Encrustation of urinary catheters in community patients. PhD Thesis. University of Surrey
22.
Zurück zum Zitat Hesse A, Shreyger F, Tuschewisztki GJ et al (1989) Experimental investigations on dissolution of incrustations on the surfaces of catheters. Urol Int 44:364–369PubMedCrossRef Hesse A, Shreyger F, Tuschewisztki GJ et al (1989) Experimental investigations on dissolution of incrustations on the surfaces of catheters. Urol Int 44:364–369PubMedCrossRef
23.
Zurück zum Zitat Roe BH (1989) Use of bladder washouts: a study of nurses’ recommendations. J Adv Nurs 14:494–500PubMedCrossRef Roe BH (1989) Use of bladder washouts: a study of nurses’ recommendations. J Adv Nurs 14:494–500PubMedCrossRef
24.
Zurück zum Zitat Stickler DJ, Morgan SD (2006) Modulation of crystalline Proteus mirabilis biofilm development on urinary catheters. J Med Microbiol 55:489–494PubMedCrossRef Stickler DJ, Morgan SD (2006) Modulation of crystalline Proteus mirabilis biofilm development on urinary catheters. J Med Microbiol 55:489–494PubMedCrossRef
Metadaten
Titel
The effect of EDTA instillations on the rate of development of encrustation and biofilms in Foley catheters
verfasst von
Steven L. Percival
Nora A. Sabbuba
Peter Kite
David J. Stickler
Publikationsdatum
01.08.2009
Verlag
Springer-Verlag
Erschienen in
Urolithiasis / Ausgabe 4/2009
Print ISSN: 2194-7228
Elektronische ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-009-0196-2

Weitere Artikel der Ausgabe 4/2009

Urolithiasis 4/2009 Zur Ausgabe

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

Stufenschema weist Prostatakarzinom zuverlässig nach

22.04.2024 Prostatakarzinom Nachrichten

Erst PSA-Test, dann Kallikrein-Score, schließlich MRT und Biopsie – ein vierstufiges Screening-Schema kann die Zahl der unnötigen Prostatabiopsien erheblich reduzieren: Die Hälfte der Männer, die in einer finnischen Studie eine Biopsie benötigten, hatte einen hochgradigen Tumor.

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

20.04.2024 EAU 2024 Kongressbericht

Beim chronischen Harnwegsinfekt bei Frauen wird bisher meist eine Antibiotikaprophylaxe eingesetzt. Angesichts der zunehmenden Antibiotikaresistenz erweist sich das Antiseptikum Methenamin-Hippurat als vielversprechende Alternative, so die Auswertung einer randomisierten kontrollierten Studie.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.