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01.06.2011 | Original Article

The effect of genital and lower urinary tract symptoms on steroid receptor expression in women with genital prolapse

verfasst von: Christine Elisabeth Skala, Ilka Brigitte Petry, Stefan Albrich, Alexander Puhl, Gert Naumann, Heinz Koelbl

Erschienen in: International Urogynecology Journal | Ausgabe 6/2011

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Abstract

Introduction and hypothesis

This study evaluates the expression of estrogen receptor (ER) isoforms alpha (α) and beta (β) and progesterone receptor (PR) in vaginal and periurethral tissue in women with genital prolapse in relation to genital and lower urinary tract symptoms (LUTS).

Methods

Forty-seven postmenopausal women without systemic estrogen therapy underwent pelvic organ prolapse quantification and urodynamic assessment. LUTS were evaluated by CATI questionnaire. Biopsies from vaginal and periurethral tissue were obtained during prolapse surgery. The steroid receptor gene expression was measured by RT-PCR.

Results

The expression of PR in periurethral and ER β in vaginal tissue varied with prolapse extent. Nulliparous women showed a significantly higher expression of PR in periurethral tissue. Women with a positive stress test and those with overactive bladder symptoms showed a significantly lower amount of PR in vaginal tissue.

Conclusion

Changes in PR expression in vaginal or periurethral tissue might be a marker of structural and endocrine changes.

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Titel: The effect of genital and lower urinary tract symptoms on steroid receptor expression in women with genital prolapse
verfasst von: Christine Elisabeth Skala
Ilka Brigitte Petry
Stefan Albrich
Alexander Puhl
Gert Naumann
Heinz Koelbl
Publikationsdatum: 01.06.2011
Verlag: Springer-Verlag
Erschienen in: International Urogynecology Journal / Ausgabe 6/2011
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1327-6

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The effect of genital and lower urinary tract symptoms on steroid receptor expression in women with genital prolapse

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Introduction and hypothesis

Methods

Results

Conclusion

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Springer Medizin

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Methods

Results

Conclusion

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