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European Journal of Pediatrics

Erschienen in:

02.07.2021 | Original Article

The effect of hyperbilirubinemia on motor repertoire of infants between 3 and 5 months of age

verfasst von: Aysu Kahraman, Halil Alkan, Hasan Tolga Çelik, Akmer Mutlu

Erschienen in: European Journal of Pediatrics | Ausgabe 1/2022

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Abstract

Jaundice is a common problem and occurs as a result of the increase in bilirubin level in infants. Infants may be adversely affected by this situation. The aim of this study is to determine whether neonatal jaundice affects the movements and postures of 3- to 5-month-old infants with hyperbilirubinemia and the correlation of motor repertoire at the same age with bilirubin levels. The study group included 30 infants (9 girls, 21 boys) with hyperbilirubinemia and a control group of 30 infants (11 girls, 19 boys) with typical development without hyperbilirubinemia. The motor repertoires of the infants were evaluated through detailed general movement (GM) analysis using video recordings made at 9–17 weeks post-term. The infants with hyperbilirubinemia had lower motor optimality score and subcategory scores (including observed movement patterns, age-adequate movement repertoire, observed postural patterns, and movement character) compared with the control group. The fidgety movement scores decreased as bilirubin value increased in infants.

Conclusion: Infants with hyperbilirubinemia had poorer motor repertoire when compared to a control group. For this reason, detailed GM analysis of these infants will predict probable neurodevelopmental problems and infants with needs can begin individualized early intervention suitable for movement repertoire and posture at the earliest time.

What is Known: • GMs of infants with hyperbilirubinemia were previously described. • However, the motor repertoires of infants with hyperbilirubinemia were not described in detail.
What is New: • Infants with hyperbilirubinemia had poorer motor repertoire when compared to peers. • This is important in determining the need for individualized early intervention.

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Melton K, Akinbi HT (1999) Neonatal jaundice: strategies to reduce bilirubin-induced complications. Postgrad Med 106(6):167–178. https://doi.org/10.3810/pgm.1999.11.775CrossRefPubMed

Le Pichon JB, Riordan SM, Watchko J, Shapiro SM (2017) The neurological sequelae of neonatal hyperbilirubinemia: definitions diagnosis and treatment of the kernicterus spectrum disorders (KSDs). Curr Pediatr Rev 13(3):199–209. https://doi.org/10.2174/1573396313666170815100214CrossRefPubMed

Novak I, Morgan C, Adde L, Blackman J, Boyd RN, Brunstrom-Hernandez J, Cioni G, Damiano D, Darrah J, Eliasson AC, et al (2017) Early accurate diagnosis and early intervention in cerebral palsy advances in diagnosis and treatment. JAMA Pediatr 171(9):897–907. https://doi.org/10.1001/jamapediatrics.2017.1689CrossRefPubMed

Einspieler C, Prechtl HF (2005) Prechtl’s assessment of general movements: a diagnostic tool for the functional assessment of the young nervous system. Ment Retard Dev Disabil Res Rev 11(1):61–67. https://doi.org/10.1002/mrdd.20051CrossRefPubMed

Prechtl HF, Einspieler C, Cioni G, Bos AF, Ferrari F, Sontheimer D (1997) An early marker for neurological deficits after perinatal brain lesions. Lancet 349(9062):1361–1363. https://doi.org/10.1016/S0140-6736(96)10182-3CrossRefPubMed

Einspieler C, Peharz R, Marschik PB (2016) Fidgety movements—tiny in appearance but huge in impact. J Pediatr 92(3):64–70. https://doi.org/10.1016/j.jped.2015.12.003CrossRef

Einspieler C, Prechtl HF, Bos AF, Ferrari F, Cioni G (2004) Prechtl’s method on the qualitative assessment of general movements in preterm term and young ınfants. Mac Keith Press, London

Phagava H, Muratori F, Einspieler C, Maestro S, Apicella F, Guzzetta A, Prechtl HF, Cioni G (2008) General movements in infants with autism spectrum disorders. Georgian Med News 156:100–105

Herrero D, Einspieler C, Panvequio Aizawa CY, Mutlu A, Yang H, Nogolová A, Pansy J, Nielsen-Saines K, Marschik PB, GenGM Study Group (2017) The motor repertoire in 3- to 5-month old ınfants with down syndrome. Res Dev Disabil 67:1–8. https://doi.org/10.1016/j.ridd.2017.05.006CrossRef

10.

Tekerlek H, Mutlu A, Inal-Ince D, Livanelioglu A, Kahraman A, Eryilmaz-Polat S, Karakaya J, Ozcelik U (2021) Motor repertoire is age-inadequate in infants with cystic fibrosis. Pediatr Res 89(5):1291–1296. https://doi.org/10.1038/s41390-020-1082-4CrossRefPubMed

11.

Soorani-Lunsing I, Woltil HA, Hadders-Algra M (2001) Are moderate degrees of hyperbilirubinemia in healthy term neonates really safe for the brain? Pediatr Res 50(6):701–705. https://doi.org/10.1203/00006450-200112000-00012CrossRefPubMed

12.

Jangaard KA, Fell DB, Dodds L, Allen AC (2008) Outcomes in a population of healthy term and near-term ınfants with serum bilirubin levels of ≥325 µmol/L (≥19 mg/dL) who were born in Nova Scotia Canada Between 1994 and 2000. Pediatrics 122(1):119–124. https://doi.org/10.1542/peds.2007-0967CrossRefPubMed

13.

Çoban A, Türkmen M, Gürsoy T (2014) Yenidoğan Sarılıklarında Yaklaşım İzlem ve Tedavi Rehberi 2014. http://www.neonatology.org.tr/wp-content/uploads/2016/12/sarilik.pdf. Accessed 21 May 2021

14.

Faul F, Erdfelder E, Lang A-G, Buchner A (2007) G* Power 3: a flexible statistical power analysis program for the social behavioral and biomedical sciences. Behav Res Methods 39(2):175–191. https://doi.org/10.3758/bf03193146CrossRefPubMed

15.

Einspieler C, Bos AF, Krieber-Tomantschger M, Alvarado E, Barbosa VM, Bertoncelli N, Burger M, Chorna O, Del Secco S, DeRegnier RA et al (2019) Cerebral palsy: early markers of clinical phenotype and functional outcome. J Clin Med 8(10):1616. https://doi.org/10.3390/jcm8101616CrossRefPubMedCentral

16.

Shapiro SM (2005) Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND). J Perinatol 25(1):54–59. https://doi.org/10.1038/sj.jp.7211157CrossRefPubMed

17.

Spittle AJ, Doyle LW, Anderson PJ, Inder TE, Lee KJ, Boyd RN, Cheong JL (2010) Reduced cerebellar diameter in very preterm infants with abnormal general movements. Early Hum Dev 86(1):1–5. https://doi.org/10.1016/j.earlhumdev.2009.11.002CrossRefPubMed

18.

Lunsing RJ, Pardoen WF, Hadders-Algra M (2013) Neurodevelopment after moderate hyperbilirubinemia at term. Pediatr Res 73(5):655–660. https://doi.org/10.1038/pr.2013.28CrossRefPubMed

19.

Wusthoff CJ, Loe IM (2015) Impact of bilirubin-ınduced neurologic dysfunction on neurodevelopmental outcomes. Semin Fetal Neonatal Med 20(1):52–57. https://doi.org/10.1016/j.siny.2014.12.003CrossRefPubMedPubMedCentral

20.

Singla DA, Sharma S, Sharma M, Chaudhary S (2017) Evaluation of risk factors for exchange range hyperbilirubinemia and neurotoxicity in neonates from Hilly Terrain of India. Int J Appl Basic Med Res 7(4):228–232. https://doi.org/10.4103/ijabmr.IJABMR_298_16CrossRefPubMedPubMedCentral

21.

Perino JM (2020) Calcium levels in the neonate. Neonatal Netw 39(1):35–39. https://doi.org/10.1891/0730-0832.39.1.35CrossRefPubMed

22.

Kwong AKL, Olsen JE, Eeles AL, Einspieler C, Lee KJ, Doyle LW, Cheong JLY, Spittle AJ (2019) Occurrence of and temporal trends in fidgety general movements in infants born extremely preterm/extremely low birthweight and term-born controls. Early Hum Dev 135:11–15. https://doi.org/10.1016/j.earlhumdev.2019.05.018CrossRefPubMed

23.

Soloveichick M, Marschik PB, Gover A, Molad M, Kessel I, Einspieler C (2020) Movement Imitation Therapy for Preterm Babies (MIT-PB): a novel approach to improve the neurodevelopmental outcome of infants at high-risk for cerebral palsy. J Dev Phys Disabil 32(4):587–598. https://doi.org/10.1007/s10882-019-09707-yCrossRefPubMed

24.

Alkan H, Kahraman A, Mutlu A (2021) Early spontaneous movements of ınfants with hypoxic-ıschemic encephalopathy. Pediatr Phys Ther 33(1):18–22. https://doi.org/10.1097/PEP.0000000000000759CrossRefPubMed

25.

Novak I, Morgan C, Adde L, Blackman J, Boyd RN, Brunstrom-Hernandez J, Cioni G, Damiano D, Darrah J, Eliasson AC et al (2017) Early accurate diagnosis and early intervention in cerebral palsy: advances in diagnosis and treatment. JAMA Pediatr 171:897–907. https://doi.org/10.1001/jamapediatrics.2017.1689CrossRefPubMed

Titel: The effect of hyperbilirubinemia on motor repertoire of infants between 3 and 5 months of age
verfasst von: Aysu Kahraman
Halil Alkan
Hasan Tolga Çelik
Akmer Mutlu
Publikationsdatum: 02.07.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 1/2022
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-021-04162-4

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