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Current Obesity Reports

Erschienen in:

09.05.2020 | Obesity Treatment (CM Apovian, Section Editor)

The Fight Against Obesity Escalates: New Drugs on the Horizon and Metabolic Implications

verfasst von: Dimitrios Tsilingiris, Stavros Liatis, Maria Dalamaga, Alexander Kokkinos

Erschienen in: Current Obesity Reports | Ausgabe 2/2020

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Abstract

Purpose of Review

There is currently a steep rise in the global prevalence of obesity. Pharmaceutical therapy is a valuable component of conservative obesity therapy. Herein, medications currently in the phase of preclinical or clinical testing are reviewed, along with an overview of the mechanisms that regulate energy intake and expenditure. In addition, the current and potential future directions of obesity drug therapy are discussed.

Recent Findings

Although the current arsenal of obesity pharmacotherapy is limited, a considerable number of agents that exert their actions through a variety of pharmacodynamic targets and mechanisms are in the pipeline. This expansion shapes a potential near future of obesity conservative management, characterized by tailored combined therapeutic regimens, targeting not only weight loss but also improved overall health outcomes.

Summary

The progress regarding the elucidation of the mechanisms which regulate the bodily energy equilibrium has led to medications which mimic hormonal adaptations that follow bariatric surgery, in the quest for a “Medical bypass.” These, combined with agents which could increase energy expenditure, point to a brilliant future in the conservative treatment of obesity.

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Titel: The Fight Against Obesity Escalates: New Drugs on the Horizon and Metabolic Implications
verfasst von: Dimitrios Tsilingiris
Stavros Liatis
Maria Dalamaga
Alexander Kokkinos
Publikationsdatum: 09.05.2020
Verlag: Springer US
Erschienen in: Current Obesity Reports / Ausgabe 2/2020
Elektronische ISSN: 2162-4968
DOI: https://doi.org/10.1007/s13679-020-00378-x

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