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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.04.2010

The Future of Stem Cell Transplantation in Autoimmune Disease

verfasst von: Susumu Ikehara

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2-3/2010

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Abstract

We have previously found that conventional allogeneic bone marrow transplantation (allo BMT) can be used to treat various spontaneously developed autoimmune diseases in mice. In addition, we have found that autoimmune diseases can be transferred into the normal mice by conventional BMT from autoimmune-prone mice. Based on these findings, we have proposed that autoimmune diseases are “stem cell disorders.” To apply allo BMT to humans, we extensively carried out BMT to clarify which cells are essential for successful BMT, and finally found that three types of cells are essential for successful allogeneic BMT: (1) hemopoietic stem cells (HSCs), (2) natural suppressor cells, and (3) stromal cells (including mesenchymal stem cells, MSCs). We have very recently found that MSCs play a crucial role in preventing graft failure, since there is a major histocompatibility complex restriction between HSCs and MSCs. To recruit donor-derived MSCs, we have found that the injection of whole bone marrow cells into the bone marrow cavity (intra-bone marrow-BMT, IBM-BMT) is the best strategy for the treatment of various otherwise intractable diseases, including autoimmune diseases. In this review article, we provide evidence that IBM-BMT heralds a revolution in the field of transplantation and regeneration medicine.

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Titel: The Future of Stem Cell Transplantation in Autoimmune Disease
verfasst von: Susumu Ikehara
Publikationsdatum: 01.04.2010
Verlag: Humana Press Inc
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 2-3/2010
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-009-8159-5

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