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Arthritis Research & Therapy

Erschienen in:

01.05.2002 | Review

The immunological synapse

verfasst von: Michael L Dustin

Erschienen in: Arthritis Research & Therapy | Sonderheft 3/2002

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Chapter summary

T-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes place in a specialized cell–cell junction referred to as an immunological synapse. The immunological synapse contains at least two functional domains: a central cluster of engaged antigen receptors and a surrounding ring of adhesion molecules. The segregation of the T-cell antigen receptor (TCR) and adhesion molecules is based on size, with the TCR interaction spanning 15 nm and the lymphocyte-function-associated antigen-1 (LFA-1) interaction spanning 30–40 nm between the two cells. Therefore, the synapse is not an empty gap, but a space populated by both adhesion and signaling molecules. This chapter considers four aspects of the immunological synapse: the role of migration and stop signals, the role of the cytoskeleton, the role of self-antigenic complexes, and the role of second signals.

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Titel: The immunological synapse
verfasst von: Michael L Dustin
Publikationsdatum: 01.05.2002
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe Sonderheft 3/2002
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar559

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