background
Methods
Study design
Neuropsychological examination
Biochemical analyses
Virologic and immunologic markers
Statistical methods
Results
Study population
Variable | |
---|---|
Age (ys) | 51.0 ± 9.8 |
Gender, n(%) | |
Male | 50 (87.7) |
Female | 7 (12.3) |
BMI (Kg/m2) | 25.7 ± 3.6 |
Level of instruction (ys) | 10.8 ± 3.1 |
History of HIV infection (ys) | 11.1 ± 7.5 |
Risk factors, n(%) | |
MSM | 22 (38.6) |
Ex-IDU | 11 (19.1) |
Heterosexual | 24 (42.1) |
Therapy, n(%) | |
NRTI | 53 (93.0) |
NNRTI | 20 (35.1) |
IP | 20 (35.1) |
INSTIs | 20 (35.1) |
HCV, n(%) | 9 (15.8) |
HBV, n(%) | 6 (10.5) |
Glycaemia (mg/dl) | 98.8 ± 48.8 |
Total cholesterol (mg/dl) | 198.2 ± 44.2 |
HDL cholesterol (mg/dl) | 51.8 ± 16.9 |
LDL cholesterol (mg/dl) | 113.4 ± 40.0 |
Triglycerides (mg/dl) | 164.8 ± 99.0 |
Creatinine (mg/dl) | 1.0 ± 0.9 |
Albumin (g/dl) | 4.6 ± 1.0 |
25-0H D Vitamin (ng/ml) | 26.8 ± 9.3 |
Homocysteine (μmol/l) | 15.1 ± 6.3 |
B12 Vitamin (ng/ml) | 378.5 ± 151.8 |
Folate (ng/ml) | 9.8 ± 13.7 |
Homocysteine, B12, and D Vitamins
Neurocognitive examination
Median (IQR) | Normality Range/Cut-off | Pathologic Test, n (%) | |
---|---|---|---|
MEMORY | 12 (21.1)* | ||
Rey BT | 39.0 (34.0–44.0) | > 28.53 | 9 (15.8) |
Rey LT | 8.0 (6.0–10.0) | > 4.69 | 11 (19.3) |
ATTENTION AND WORKING MEMORY | 38 (66.7)* | ||
Verbal Span forward | 5.0 (4.0–6.0) | 5.00–9.00 | 18 (31.6) |
Spatial Span forward | 3.0 (3.0–5.0) | 5.00–9.00 | 37 (64.9) |
Double barrage | 1.0 (1.0–1.0) | > 0.92 | 6 (10.5) |
EXECUTIVE FUNCTIONS | 33 (57.9)* | ||
Stroop E | 1.0 (0–2.0) | < 4.24 | 8 (14.0) |
Stroop T | 19.0 (14.0–28.0) | < 36.91 | 10 (17.5) |
Trail making test B - T | 149.0 (112.0–220.0) | 111.29″-248.89″ | 10 (17.5) |
Trail making test B - E | 1.0 (0–2.0) | −0.21-2.39 | 6 (10.5) |
Drawings | 5.0 (3.0–6.0) | 3.85–6.15 | 16 (28.1) |
Wais Digit span | 33.0 (23.0–45.0) | > 6.00 | 14 (24.6) |
LANGUAGE | 5 (8.8)* | ||
Verbal fluency test | 33.0 (27.0–41.0) | > 17.35 | 5 (8.8) |
SPEED OF PSYCHOMOTOR PROCESSING | 18 (31.6)* | ||
Pegboard dom | 72.0 (62.0–82.0) | 55.94–74.32 | 18 (31.6) |
Pegboard non dom | 75.0 (68.0–85.0) | 59.68–80.30 | 10 (17.5) |
DEPRESSION | 12 (21.1)* | ||
Zung depression score | 38.0 (31.0–46.0) | < 50.00 | 12 (21.1) |
DAILY LIFE ACTIVITY | – | ||
IADL | 8.0 (8.0–8.0) | < 7.00 | – |
Clinical variables and neurocognitive functions
Cognitive test | Homocysteine |
p-value
a
| 25-OH D Vitamin |
p-value
a
| B-12 Vitamin | ||||
---|---|---|---|---|---|---|---|---|---|
Non-Pathologic (n = 17) | Pathologic (n = 40) | Non-Pathologic (n = 49) | Pathologic (n = 8) | Non-Pathologic (n = 49) | Pathologic (n = 8) |
p-value
a
| |||
Rey word BT | 38.0 (31.0–43.3) | 39.0 (32.5–44.3) |
0.897
| 39.5 (34.0–44.3) | 31.0 (22.5–38.8) |
0.144
| 39.5 (33.5–45.5) | 39.0 (23.0–40.5) |
0.395
|
Rey word LT | 7.0 (4.0–10.0) | 8.0 (6.0–9.8) |
0.401
| 7.0 (5.0–9.8) | 5.5 (4.0–7.8) |
0.195
| 7.5 (5.0–10.0) | 7.0 (4.0–9.0) |
0.421
|
Verbal Span Forward | 5.0 (3.0–6.0) | 5.0 (4.0–6.0) |
0.615
| 5.0 (4.0–6.0) | 5.0 (5.0–5.8) |
0.589
| 5.0 (4.0–6.0) | 5.0 (2.5–5.5) |
0.873
|
Spatial Span Forward | 4.0 (3.0–5.0) | 3.5 (3.0–5.0) |
0.662
| 4.0 (3.0–5.0) | 4.0 (3.0–5.0) |
0.874
| 4.0 (3.0–5.0) | 5.0 (2.5–5.5) |
0.567
|
Stroop E Test | 2.0 (1.8–3.5) | 1.0 (0–2.0) |
0.040
| 1.0 (0–2.0) | 3.0 (2.0–10.8) |
0.049
| 1.5 (0–2.0) | 4.0 (0.5–9.5) |
0.155
|
Stroop T Test | 20.0 (13.5–38.5) | 17.0 (12.3–26.0) |
0.565
| 17.0 (13.3–26.0) | 24.0 (14.5–39.5) |
0.065
| 16.0 (12.8–26.3) | 26.0 (17.0–50.0) |
0.185
|
Trail B T | 154.0 (107.0–236.3) | 137.5 (92.3–213.0) |
0.660
| 131.5 (96.0–195.3) | 281.0 (152.3–403.8) |
0.035
| 133.5 (93.8–198.8) | 338.0 (186.5–387.5) |
0.002
|
Trail B E | 1.0 (0–1.8) | 0 (0–2.0) |
0.298
| 0 (0–2.0) | 1.5 (0.3–3.5) |
0.408
| 0 (0–1.3) | 2.0 (0–4.0) |
0.257
|
Drawings | 5.5 (4.0–6.0) | 4.5 (2.3–6.0) |
0.170
| 4.5 (3.0–6.0) | 2.0 (0–5.5) |
0.157
| 5.0 (4.0–6.0) | 2.0 (0.5–4.0) |
0.054
|
Verbal Fluency | 24.0 (17.0–33.3) | 36.5 (29.3–48.0) |
0.003
| 34.5 (29.0–41.5) | 23.0 (16.0–42.0) |
0.629
| 34.5 (27–47.3) | 24.0 (17.0–39.5) |
0.237
|
Wais Digit Span | 29.5 (19.3–49.3) | 33.5 (21.5–44.0) |
0.909
| 32.0 (23.0–44.0) | 12.5 (6.8–29.5) |
0.042
| 33.5 (22.5–46.3) | 9.0 (6.5–32.0) |
0.029
|
Double Barrage | 12.0 (9.0–12.3) | 11.0 (10.0–12.8) |
0.836
| 11.5 (10.3–12.0) | 10.5 (9.3–12.5) |
0.195
| 11.0 (10.0–12.0) | 13.0 (9.5–13.0) |
0.395
|
Pegboard Dominant | 76.0 (66.5–79.8) | 73.5 (64.5–87.8) |
0.945
| 75.0 (67.0–80.0) | 97.5 (71.3–145.5) |
0.376
| 72.0 (64.8–80.0) | 100.0 (81.0–131.0) |
0.014
|
Pegboard Non-Dominant | 75.5 (69.0–86.8) | 77.0 (68.3–90.5) |
0.982
| 77.5 (69.3–85.8) | 96.5 (78.5–146.8) |
0.075
| 75.0 (67.5–87.5) | 83.0 (76.5–131.5) |
0.095
|
Zung Depression Score | 43.5 (33.5–53.0) | 34.5 (29.3–44.8) |
0.060
| 36.5 (29.3–48.0) | 45.5 (41.3–56.5) |
0.755
| 38.0 (30.8–46.0) | 44.0 (31.0–53.0) |
0.506
|
Odds Ratio (95%CI) |
p-value
| |
---|---|---|
25-0H D Vitamin (ng/ml) | 0.891 (0.798–0.996) |
0.042
|
Homocysteine (μmol/l) | 0.922 (0.813–1.046) |
0.207
|
B12 Vitamin (ng/ml) | 1.003 (0.998–1.008) |
0.214
|