Erschienen in:
04.12.2017 | Editorial
The importance of a well-structured pancreatic screening program for familial and hereditary pancreatic cancer
verfasst von:
Hans F. A. Vasen
Erschienen in:
Familial Cancer
|
Ausgabe 1/2018
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Excerpt
In this issue of Familial Cancer, Barnes et al. describe a screening program for individuals at high risk of developing pancreatic ductal adenocarcinoma (PDAC) [
1]. Approximately 3–10% of all patients with PDAC have a positive family history for this cancer [
2], and 4% have an underlying gene defect, with
ATM, BRCA1 & BRCA2, and
PALB2 being the most commonly effected genes [
3‐
6] (Table
1). Familial pancreatic cancer (FPC) is defined by the occurrence of PDAC in two or more first-degree relatives, in the absence of an underlying gene defect [
2]. The risk of developing PDAC depends on the particular gene defect (Table
1) [
7‐
12], and in FPC, on the number of first-degree family members with PDAC. …