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Journal of Cancer Research and Clinical Oncology

Erschienen in:

22.05.2017 | Original Article – Clinical Oncology

The influence of local therapy on the survival of patients with metastatic rectal cancer: a population-based, propensity-matched study

verfasst von: Chi-Hao Zhang, Yuan-Bo Pan, Qing-Wei Zhang, Ou-Min Shi, Lei Zheng, Liang Gui, Meng Luo

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 9/2017

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Abstract

Purpose

This study was aimed to determine the effect of the local tumor therapy on patients’ prognosis in the management of metastatic rectal cancer.

Methods

Patients diagnosed with metastatic rectal cancer from 2004 to 2013 were selected from the SEER (Surveillance, Epidemiology, and End Results) database. Overall survival and cancer-specific survival were compared between the local treatment group and the nonlocal treatment group using Kaplan–Meier methods. Uni- and multivariate analyses were further performed to confirm or deny the results. The statistical approach of propensity score matching was conducted to avoid potential confounding factors.

Results

Of 6867 patients included in this analysis, 3971 (57.8%) received local therapy to the primary tumor and 2896 (42.2%) did not receive. Both univariable and multivariable analysis showed local therapy continued to be associated with an improvement in OS (HR 0.532; 95% CI 0.503–0.563, p < 0.001 and HR 0.532; 95% CI 0.498–0.568, p < 0.001, respectively) and CSS (HR 0.527; 95% CI 0.497–0.559, p < 0.001 and HR 0.521; 95% CI 0.487–0.557, p < 0.001, respectively) in the unmatched cohorts. Further analysis showed patients underwent local tumor destruction or surgical resection had a better overall survival compared with those who did not undergo (p < 0.001). In the matched population, patients receiving local therapy had a better OS (HR 0.427; 95% CI 0.428–0.519, p < 0.001) and CSS (HR 0.462; 95% CI 0.418–0.511, p < 0.001) compared with those who did not receive.

Conclusions

Local therapy to the primary tumor may be associated with a better survival in patients with metastatic rectal cancer.

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Titel: The influence of local therapy on the survival of patients with metastatic rectal cancer: a population-based, propensity-matched study
verfasst von: Chi-Hao Zhang
Yuan-Bo Pan
Qing-Wei Zhang
Ou-Min Shi
Lei Zheng
Liang Gui
Meng Luo
Publikationsdatum: 22.05.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 9/2017
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-017-2442-2

Springer Medizin

The influence of local therapy on the survival of patients with metastatic rectal cancer: a population-based, propensity-matched study