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06.06.2016 | Original Contribution

The interaction between ApoA2 −265T>C polymorphism and dietary fatty acids intake on oxidative stress in patients with type 2 diabetes mellitus

verfasst von: Elham Zamani, Haleh Sadrzadeh-Yeganeh, Gity Sotoudeh, Laleh Keramat, Mohammadreza Eshraghian, Masoumeh Rafiee, Fariba Koohdani

Erschienen in: European Journal of Nutrition | Ausgabe 5/2017

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Abstract

Introduction

Apolipoprotein A2 (APOA2) −265T>C polymorphism has been studied in relation to oxidative stress and various dietary fatty acids. Since the interaction between APOA2 polymorphism and dietary fatty acids on oxidative stress has not yet discussed, we aimed to investigate the interaction on oxidative stress in type 2 diabetes mellitus (T2DM) patients.

Methods

The subjects were 180 T2DM patients with known APOA2 genotype, either TT, TC or CC. Superoxide dismutase (SOD) activity was determined by colorimetric method. Total antioxidant capacity (TAC) and serum level of 8-isoprostane F2α were measured by spectrophotometry and ELISA, respectively. Dietary intake was collected through a food frequency questionnaire. Based on the median intake, fatty acids intake was dichotomized into high or low groups. The interaction between APOA2 polymorphism and dietary fatty acids intake was analyzed by ANCOVA multivariate interaction model.

Results

Higher than median intake of omega-6 polyunsaturated fatty acids (n-6 PUFA) was associated with increased serum level of 8-isoprostane F2α in subjects with TT/TC genotype (p = 0.004), and higher than median intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) was associated with increased serum SOD activity in CC genotype (p < 0.001). There was a statistically significant interaction between APOA2 polymorphism and n-6 PUFA intake on 8-isoprostane F2α concentration as well as n-3 PUFA intake on serum SOD activity (p-interaction = 0.04 and 0.02, respectively).

Conclusions

The current study shows the interaction between APOA2 polymorphism and dietary fatty acids intake on oxidative stress. More investigations on different populations are required to confirm the interaction.

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Titel: The interaction between ApoA2 −265T>C polymorphism and dietary fatty acids intake on oxidative stress in patients with type 2 diabetes mellitus
verfasst von: Elham Zamani
Haleh Sadrzadeh-Yeganeh
Gity Sotoudeh
Laleh Keramat
Mohammadreza Eshraghian
Masoumeh Rafiee
Fariba Koohdani
Publikationsdatum: 06.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1235-8

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The interaction between ApoA2 −265T>C polymorphism and dietary fatty acids intake on oxidative stress in patients with type 2 diabetes mellitus

Abstract

Introduction

Methods

Results

Conclusions

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Abstract

Introduction

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Conclusions

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