Introduction
Materials and methods
Patients
Clinical and Laboratory Assessments
Determination of Serum Adiponectin Level and TNF-α
Virological Assessment
Statistical Analysis
Results
Characteristics and Clinical Parameters of study population
Characteristics of patients (n = 92)
|
Mean ± SD
|
---|---|
Age(Years) | 39 ± 10 |
BMI (kg/m2) | 25.5 ± 1.2 |
FBS (mg/dl) | 85 ± 13 |
Albumin (g/dl) | 4.3 ± 0.5 |
Bilirubin total (mg%) | 0.6 ± 0.3 |
ALT (IU/l) | 48 ± 51 |
Cholesterol (mg/dl) | 168 ± 33 |
Triglyceride (mg/dl) | 138 ± 42 |
HDL (mg/dl) | 49 ± 11 |
Adiponectin (ng/ml) | 9.7 ± 5.2 |
TNF-alpha (ng/L) | 10.6 ± 3.6 |
HBV DNA (log copies/ml) | 3.7 ± 0.9 |
Biochemical Evaluation in Patients with Chronic Hepatitis B
Association of Serum HDL and Adiponectin with HBV DNA
Clinical factor |
HBV DNA < median *
|
HBV DNA > median *
|
P value
|
---|---|---|---|
Age (Years)
| 41 ± 10 | 38 ± 11 |
0.12
|
BMI (kg/m2)
| 25.4 ± 1.1 | 25.6 ± 1.2 |
0.47
|
FBS (mg/dl)
| 83 ± 14 | 86 ± 8 |
0.2
|
Albumin (g/dl)
| 4.3 ± 0.5 | 4.2 ± 0.5 |
0.7
|
Bilirubin total (mg%)
| 0.5 ± 0.2 | 0.6 ± 0.2 |
0.7
|
ALT (IU/l)
| 36 ± 26 | 61 ± 65 |
0.021
|
Cholesterol (mg/dl)
| 172 ± 31 | 164 ± 34 |
0.27
|
Triglyceride (mg/dl)
| 136 ± 44 | 140 ± 39 |
0.62
|
HDL (mg/dl)
| 52 ± 12 | 47 ± 10 |
0.04
|
Adiponectin (μg/ml)
| 10.7 ± 4.9 | 8.7 ± 5.3 |
0.057
|
TNF-a (ng/L)
| 9.7 ± 2.7 | 11.5 ± 4.2 |
0.017
|