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International Journal of Clinical Oncology

Erschienen in:

01.08.2014 | Original Article

The modified Glasgow Prognostic Score (mGPS) is a good predictor of indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers

verfasst von: Yoshiaki Ikuta, Hiroshi Takamori, Yasuo Sakamoto, Daisuke Hashimoto, Akira Chikamoto, Hideyuki Kuroki, Kazuya Sakata, Keita Sakamoto, Hiromitsu Hayashi, Katsunori Imai, Hidetoshi Nitta, Masahiko Hirota, Keiichiro Kanemitsu, Toru Beppu, Hideo Baba

Erschienen in: International Journal of Clinical Oncology | Ausgabe 4/2014

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Abstract

Background

Patients with unresectable pancreatic and biliary cancers sometimes need decompression due to obstruction of the gastrointestinal tract and/or biliary tract. The aim of this study was to determine the prognostic factors associated with an indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers.

Methods

Between April 2005 and September 2011, 37 patients with unresectable pancreatic and biliary cancers underwent palliative bypass surgery. Prognostic factors were searched for among clinical characteristics, operation-related factors, and tumor-related factors using a prospective database.

Results

The median survival time (MST) of these patients was 4.6 months, with a 6-month survival rate of 40.5 %. A multivariate Cox proportional hazards regression analysis revealed that mGPS >2 was the only independent prognostic factor for bypass surgery. Patients with an mGPS of 2 had an MST of 1.7 months, and they had a significantly worse prognosis than mGPS 0–1 patients with an MST of 6.3 months.

Conclusions

The mGPS is useful for predicting survival after surgical decompression due to gastrointestinal obstruction in patients with unresectable pancreatic and biliary cancers. Patients with a poor mGPS may not be indicated for palliative bypass surgery.

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Titel: The modified Glasgow Prognostic Score (mGPS) is a good predictor of indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers
verfasst von: Yoshiaki Ikuta
Hiroshi Takamori
Yasuo Sakamoto
Daisuke Hashimoto
Akira Chikamoto
Hideyuki Kuroki
Kazuya Sakata
Keita Sakamoto
Hiromitsu Hayashi
Katsunori Imai
Hidetoshi Nitta
Masahiko Hirota
Keiichiro Kanemitsu
Toru Beppu
Hideo Baba
Publikationsdatum: 01.08.2014
Verlag: Springer Japan
Erschienen in: International Journal of Clinical Oncology / Ausgabe 4/2014
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI: https://doi.org/10.1007/s10147-013-0613-y

Springer Medizin

The modified Glasgow Prognostic Score (mGPS) is a good predictor of indication for palliative bypass surgery in patients with unresectable pancreatic and biliary cancers