Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Neurological Sciences
Erschienen in: Neurological Sciences 9/2017

01.09.2017 | Review Article

The neuropathological basis to the functional role of microglia/macrophages in gliomas

verfasst von: Davide Schiffer, Marta Mellai, Enrica Bovio, Laura Annovazzi

Erschienen in: Neurological Sciences | Ausgabe 9/2017

Einloggen, um Zugang zu erhalten

Abstract

The paper wants to be a tracking shot of the main recent acquisitions on the function and significance of microglia/macrophages in gliomas. The observations have been principally carried out on in vitro cultures and on tumor transplants in animals. Contrary to what is deduced from microglia in non-neoplastic pathologic conditions of central nervous system (CNS), most conclusions indicate that microglia acts favoring tumor proliferation through an immunosuppression induced by glioma cells. By immunohistochemistry, different microglia phenotypes are recognized in gliomas, from ramified microglia to frank macrophagic aspect. One wonders whether the functional conclusions drawn from many microglia studies, but not in conditions of human pathology, apply to all the phenotypes recognizable in them. It is difficult to verify in human pathology a prognostic significance of microglia. Only CD163-positive microglia/macrophages inversely correlate with glioma patients' survival, whereas the total number of microglia does not change with the malignancy grade.
Literatur
1.
2.
Shaked I, Porat Z, Gersner R, Kipnis J, Schwartz M (2004) Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system. J Neuroimmunol 146:84–93CrossRefPubMed
3.
Ulvestad E, Williams K, Bjerkvig R, Tiekotter K, Antel J, Matre R (1994) Human microglial cells have phenotypic and functional characteristics in common with both macrophages and dendritic antigen-presenting cells. J Leukoc Biol 56:732–740PubMed
4.
Miescher S, Whiteside TL, de Tribolet N, von Fliedner V (1988) In situ characterization, clonogenic potential, and antitumor cytolytic activity of T lymphocytes infiltrating human brain cancers. J Neurosurg 68:438–448CrossRefPubMed
5.
6.
Badie B, Schartner J (2001) Role of microglia in glioma biology. Microsc Res Tech 54:106–113CrossRefPubMed
7.
8.
Markovic DS, Vinnakota K, Chirasani S et al (2009) Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion. Proc Natl Acad Sci U S A 106:12530–12535CrossRefPubMedPubMedCentral
9.
Gabrusiewicz K, Ellert-Miklaszewska A, Lipko M, Sielska M, Frankowska M, Kaminska B (2011) Characteristics of the alternative phenotype of microglia/macrophages and its modulation in experimental gliomas. PLoS One 6:e23902CrossRefPubMedPubMedCentral
10.
Vinnakota K, Hu F, Ku MC et al (2013) Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. Neuro-Oncology 15:1457–1468CrossRefPubMedPubMedCentral
11.
Perry VH, Teeling J (2013) Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration. Semin Immunopathol 35:601–612CrossRefPubMedPubMedCentral
12.
Glass R, Synowitz M (2014) CNS macrophages and peripheral myeloid cells in brain tumours. Acta Neuropathol 128:347–362CrossRefPubMed
13.
Lisi L, Stigliano E, Lauriola L, Navarra P, Dello Russo C (2014) Proinflammatory-activated glioma cells induce a switch in microglial polarization and activation status, from a predominant M2b phenotype to a mixture of M1 and M2a/B polarized cells. ASN Neuro 6:171–183CrossRefPubMed
14.
Szulzewsky F, Pelz A, Feng X et al (2015) Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS One 10:e0116644CrossRefPubMedPubMedCentral
15.
Qin T, Wang C, Chen X et al (2015) Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma. Toxicol Appl Pharmacol 286:112–123CrossRefPubMed
16.
Xu S, Wei J, Wang F et al (2014) Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J Natl Cancer Inst 106. pii:dju162.
17.
Shen X, Burguillos MA, Osman AM et al (2016) Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. Nat Immunol 17:1282–1290CrossRefPubMed
18.
Grauwet K, Chiocca EA (2016) Glioma and microglia, a double entendre. Nat Immunol 17:1240–1242CrossRefPubMed
19.
20.
da Fonseca AC, Badie B (2013) Microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies. Clin Dev Immunol 2013:264124PubMed
21.
Hambardzumyan D, Gutmann DH, Kettenmann H (2016) The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci 19:20–27CrossRefPubMedPubMedCentral
22.
23.
Watters JJ, Schartner JM, Badie B (2005) Microglia function in brain tumors. J Neurosci Res 81:447–455CrossRefPubMed
24.
Sonabend AM, Rolle CE, Lesniak MS (2008) The role of regulatory T cells in malignant glioma. Anticancer Res 28:1143–1150PubMed
25.
Kamran N, Chandran M, Lowenstein PR, Castro MG (2016) Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy. Clin Immunol. pii:S1521-6616(16)30518-6
26.
Chang AL, Miska J, Wainwright DA et al (2016) CCL2 produced by the Glioma microenvironment is essential for the recruitment of regulatory T cells and myeloid-derived suppressor cells. Cancer Res 76:5671–5682CrossRefPubMed
27.
Hwang JS, Jung EH, Kwon MY, Han IO (2016) Glioma-secreted soluble factors stimulate microglial activation: the role of interleukin-1β and tumor necrosis factor-α. J Neuroimmunol 298:165–171CrossRefPubMed
28.
Barnum SR (1999) Inhibition of complement as a therapeutic approach in inflammatory central nervous system (CNS) disease. Mol Med 5:569–582PubMedPubMedCentral
29.
Morioka T, Baba T, Black KL, Streit WJ (1992) Immunophenotypic analysis of infiltrating leukocytes and microglia in an experimental rat glioma. Acta Neuropathol 83:590–597CrossRefPubMed
30.
Pong WW, Higer SB, Gianino SM, Emnett RJ, Gutmann DH (2013) Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. Ann Neurol 73:303–308CrossRefPubMedPubMedCentral
31.
Daginakatte GC, Gutmann DH (2007) Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth. Hum Mol Genet 16:1098–1112CrossRefPubMed
32.
Morimura T, Neuchrist C, Kitz K et al (1990) Monocyte subpopulations in human gliomas: expression of fc and complement receptors and correlation with tumor proliferation. Acta Neuropathol 80:287–294CrossRefPubMed
33.
Sutter A, Hekmat A, Luckenbach GA (1991) Antibody-mediated tumor cytotoxicity of microglia. Pathobiology 59:254–258CrossRefPubMed
34.
Komohara Y, Ohnishi K, Kuratsu J, Takeya M (2008) Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol 216:15–24CrossRefPubMed
35.
Zhang H, Zhang W, Sun X et al (2016) Class A1 scavenger receptor modulates glioma progression by regulating M2-like tumor-associated macrophage polarization. Oncotarget 7:50099–50116CrossRefPubMedPubMedCentral
36.
37.
Ye XZ, Xu SL, Xin YH et al (2012) Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway. J Immunol 189:444–453CrossRefPubMed
38.
Yi L, Xiao H, Xu M et al (2011) Glioma-initiating cells: a predominant role in microglia/macrophages tropism to glioma. J Neuroimmunol 232:75–82CrossRefPubMed
39.
Noorani I, Petty G, Grundy PL et al (2015) Novel association between microglia and stem cells in human gliomas: a contributor to tumour proliferation? J Pathol Clin Res 1:67–75CrossRefPubMedPubMedCentral
40.
Zhou W, Ke SQ, Huang Z et al (2015) Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. Nat Cell Biol 17:170–182CrossRefPubMedPubMedCentral
41.
42.
Brandenburg S, Müller A, Turkowski K et al (2016) Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathol 131:365–378CrossRefPubMed
43.
Coniglio S, Miller I, Symons M, Segall JE (2016) Coculture assays to study macrophage and microglia stimulation of glioblastoma invasion. J Vis Exp 116
44.
Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB (2006) The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro-Oncology 8:261–279CrossRefPubMedPubMedCentral
45.
Parney IF, Waldron JS, Parsa AT (2009) Flow cytometry and in vitro analysis of human glioma-associated macrophages. Laboratory investigation J Neurosurg 110:572–582
46.
47.
Prinz M, Tay TL, Wolf Y, Jung S (2014) Microglia: unique and common features with other tissue macrophages. Acta Neuropathol 128:319–331CrossRefPubMed
48.
Müller A, Brandenburg S, Turkowski K, Müller S, Vajkoczy P (2015) Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells. Int J Cancer 137:278–288CrossRefPubMed
49.
Zhu W, Carney KE, Pigott VM et al (2016) Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+ exchanger isoform 1. Carcinogenesis 37:839–851CrossRefPubMedPubMedCentral
50.
Szulzewsky F, Arora S, de Witte L et al (2016) Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples. Glia 64:1416–1436CrossRefPubMed
51.
Kettenmann H, Hanisch UK, Noda M, Verkhratsky A (2011) Physiology of microglia. Physiol Rev 91:461–553CrossRefPubMed
52.
Sielska M, Przanowski P, Wylot B et al (2013) Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response. J Pathol 230:310–321CrossRefPubMed
53.
Coniglio SJ, Eugenin E, Dobrenis K et al (2012) Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol Med 18:519–527CrossRefPubMedPubMedCentral
54.
Sarkar S, Döring A, Zemp FJ et al (2014) Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nat Neurosci 17:46–55CrossRefPubMed
55.
Placone AL, Quiñones-Hinojosa A, Searson PC (2016) The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment. Tumour Biol 37:61–69CrossRefPubMed
56.
Barros MH, Hauck F, Dreyer JH, Kempkes B, Niedobitek G (2013) Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages. PLoS One 8:e80908CrossRefPubMedPubMedCentral
57.
Schiffer D (1991) Pathology and neuroepidemiology of the brain and nervous system. Curr Opin Oncol 3:449–458CrossRefPubMed
58.
Hochreiter-Hufford A, Ravichandran KS (2013) Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion. Cold Spring Harb Perspect Biol 5:a008748CrossRefPubMedPubMedCentral
59.
Bayerl SH, Niesner R, Cseresnyes Z et al (2016) Time lapse in vivo microscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia. Glia 64:1210–1226CrossRefPubMed
60.
Prosniak M, Harshyne LA, Andrews DW et al (2013) Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers. Clin Cancer Res 19:3776–3786CrossRefPubMed
61.
Christofides A, Kosmopoulos M, Piperi C (2015) Pathophysiological mechanisms regulated by cytokines in gliomas. Cytokine 71:377–384CrossRefPubMed
62.
Michelson N, Rincon-Torroella J, Quiñones-Hinojosa A, Greenfield JP (2016) Exploring the role of inflammation in the malignant transformation of low-grade gliomas. J Neuroimmunol 297:132–140CrossRefPubMed
Metadaten
Titel
The neuropathological basis to the functional role of microglia/macrophages in gliomas
verfasst von
Davide Schiffer
Marta Mellai
Enrica Bovio
Laura Annovazzi
Publikationsdatum
01.09.2017
Verlag
Springer Milan
Erschienen in
Neurological Sciences / Ausgabe 9/2017
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-017-3002-x

Weitere Artikel der Ausgabe 9/2017

Neurological Sciences 9/2017 Zur Ausgabe

Original Article

Continuous quantitative monitoring of physical activity in Parkinson’s disease patients by using wearable devices: a case-control study

LETTER TO THE EDITOR

Compound heterozygosity in the GALC gene in a late onset Iranian patient with spastic paraparesis, peripheral neuropathy and leukoencephalopathy

Review Article

The contribution of surgical brain mapping to the understanding of the anatomo-functional basis of syntax: A critical review

Original Article

Brainstem reflexes are hyperactive in patients with drug-induced akathisia

Original Article

Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy

Review Article

Effects of robot-assisted upper limb rehabilitation in stroke patients: a systematic review with meta-analysis

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise