Introduction
Overactive bladder (OAB) is a common condition characterized by urinary urgency, usually accompanied by increased daytime frequency and/or nocturia, with or without urgency urinary incontinence (UUI; OAB-wet or OAB-dry, respectively), in the absence of urinary tract infection or other detectable disease [
1,
2].
Some 546 million individuals worldwide were expected to be affected by OAB in 2018 [
3], with the overall prevalence increasing with advancing age and highest rates reported in those aged 65–80 years [
4‐
7]. OAB appears to affect similar proportions of women and men, although some of the available evidence suggests a slightly higher prevalence in women [
3‐
5,
8]. The prevalence estimates for women in large population- or community-based epidemiologic studies range from 1.9% in China [
9] to 8.1% in Japan [
10] and 24.7% in the USA [
5]. There is some evidence of an impact of race and ethnicity on the symptoms of OAB (although data are mainly limited to US populations) [
11,
12].
The negative impact of OAB symptoms on psychosocial functioning and health-related quality of life (HRQoL) has been well documented [
8,
13]. It is expected that daily living and participation in both social and occupational activities can be profoundly affected by OAB symptoms. A number of studies have therefore focused on the physical and emotional dimensions that have the most impact on HRQoL [
14]. OAB has also been associated with anxiety and depression [
15] and sleep disturbance [
8]. Urinary incontinence, in particular, may have severe psychologic and social consequences, for example, an unwillingness to leave home without a familiarity of access to toilets. In addition, OAB represents a heavy socioeconomic burden, affecting both employment and productivity [
12,
16‐
18].
A systematic literature review estimated the total national cost of OAB in the USA to be $65.9 billion in 2007, with an estimated increase to $82.6 billion in 2020 [
19]. An analysis of six western countries (Canada, Germany, Italy, Spain, Sweden and the UK) estimated that the total direct costs of OAB (excluding nursing home and productivity costs) were in excess of €3.5 billion (2005 costs) [
20].
If conservative management strategies are ineffective, pharmacotherapy with oral antimuscarinics or beta-3 adrenoceptor agonists may result in OAB symptom improvement [
21,
22]. Yet, despite the high burden from OAB and the availability of effective treatments, the number of patients with OAB seeking medical advice is consistently limited [
23‐
26]. Few studies have investigated the prevalence of OAB symptoms and the associated treatment-seeking behavior in the Middle East, and none of the available studies have attempted to establish baseline data at a national or regional level [
27‐
30].
Methods
Study Design
This study was a cross-sectional, population-based telephone survey to identify women residing in Algeria, Jordan, Lebanon or Egypt with symptoms suggestive of OAB as measured by the validated OAB-V8 symptom bother questionnaire [
31‐
33] over approximately 4 months in 2018.
Patient Recruitment and Eligibility
Women aged ≥ 40 years who were residing in one of the four countries (Algeria, Egypt, Jordan and Lebanon) during the study and who provided verbal informed consent via telephone were included. Women who reported currently being pregnant and/or had symptoms consistent with other obvious urinary conditions (e.g., fever, dysuria and/or hematuria), including urinary tract infections, were excluded.
Data Collection
Data were collected directly from survey participants using the computer-assisted telephone interview (CATI) method [
34]. Random Digit Dialing computer software was used to assist in determining telephone numbers to dial for each country from a national public telephone directory. This sampling methodology was utilized to maximize the coverage in all areas in each country (including urban, semi-urban and rural areas), taking landline area code into consideration. Based on our assumptions [30% of phone calls would be answered; 50% of households would have an eligible woman available; 15% of women would be aged ≥ 40 years; 30% would agree to consent and participate; and with a 15% prevalence of OAB (with a uniform prevalence across all countries)], it was estimated that a sample size of 550 women per country (total 2200) would achieve a margin of error of ± 3% with a 95% confidence level (CI). Overall, it was estimated that 2.3% of women contacted would be eligible and willing to participate.
Conduct of the Survey
After providing a brief overview of the study, including the objective (conducting a health-related telephone survey) and the expected duration (< 15 min to complete the interview), the eligibility of each respondent was established (Table S1). Following confirmation of verbal consent, respondents were advised that they were free to withdraw from the study at any point during the call without having to provide any reason(s). Respondents were invited to complete the OAB-V8 questionnaire in their preferred language [English (Table S2), French, or Arabic] and were also asked to provide additional information regarding demographics and treatment behavior.
Data Analysis
Data collected from questionnaires were captured immediately on an electronic case report form electronic system to avoid data transfer errors. Data analyses were conducted using SAS Enterprise Guide, version 7.13 HF3. The OAB-V8 was designed to assess the extent of bother from four hallmark symptoms of OAB: urinary frequency, urgency, nocturia and urge incontinence [
32]. Patients responded to eight questions using a 6-point Likert scale ranging from 0 (not at all) to 5 (a very great deal), with a maximum possible score of 40. The study was not designed to diagnose OAB patients, as it was not clinic based. However, the odds ratio for having OAB vs. not having OAB among those who scored ≥ 8 on the OAB-V8 questionnaire during its validation process was 95.7 (95% CI 29.3–312.4) [
31,
32].
In our analysis, respondents who scored ≥ 8 on the OAB-V8 questionnaire plus scores ≥ 1 for questions 2 (bothered by an uncomfortable urge to urinate), 3 (bothered by a sudden urge to urinate with little or no warning) and 7 (bothered by an uncontrollable urge to urinate) were considered to have symptoms suggestive of OAB. Among respondents with symptoms of OAB, those who scored ≥ 1 on questions 4 (bothered by accidental loss of small amounts of urine) and 8 (bothered by urine loss together with a strong desire to urinate) were considered also to have urinary incontinence (OAB-wet).
Descriptive statistics were performed on qualitative data to summarize all outcome variables, including symptom description, basic demographics, comorbidities and treatment behavior. Respondents were stratified according to age (40–55, 56–64, 65–74 and ≥ 75 years), and there was no cap on any group size. Categorical variables were summarized as the number and proportion of the total study population, and by subgroups where appropriate, and continuous variables were reported as mean and standard deviation (SD). No formal hypothesis testing was performed.
Ethics Approval
The study was conducted with ethical approval and informed consent, and in accordance to Helsinki Declaration. The ethics approval procedure differed in each country. The review boards for each country and reference numbers are as follows: Egypt: Central IRB at Egyptian Ministry of Health (15-2018/19); Jordan: IRB at School of Medicine, University of Jordan (1692/2018/67); Algeria: IRB at EHU Oran Algeria and Central IRB notification to Algerian Ministry of Health (11-07-2018); Lebanon: IRB at Lebanese Hospital Geitaoui University Medical Centre (2018-IRB-010).
Discussion
The results of this population-based telephone survey suggest there is a high prevalence (53.8%) of OAB symptoms among women aged ≥ 40 years in the Middle Eastern setting, with > 90% of women with symptoms suggestive of OAB also reporting OAB-wet symptoms. OAB prevalence estimates have been shown to vary considerably among studies, ranging from approximately 3–43% [
4]. However, it is challenging to directly compare the results of this study with those of other prevalence studies, largely because of differences in methodology, e.g., inclusion of both men and women, differences in the definition of OAB, inclusion of individuals of varying age groups, and differences in treatment practices and patient perception across regions/countries.
Only a few studies have investigated the prevalence of OAB in the Middle East. One community-based study conducted by El-Azab et al. in Egypt (
n = 1652 women) reported a prevalence of 40% for OAB symptoms [
29], which is lower than the prevalence estimated in this study for Egypt (57.5%). A possible explanation for this difference may be the inclusion of younger women (≥ 20 years) in the El-Azab et al. study [
29], and it is well-established that OAB symptoms are more common in individuals of advanced age [
4].
In addition to age, other risk factors for OAB symptoms were common in this sample population of women. For example, the mean body mass index was 28.9 kg/m
2 (overweight), and most women were post-menopausal (60.8% of respondents). Additionally, approximately half of all women with symptoms suggestive of OAB experienced at least one comorbidity (48.9%), and diabetes was the second most common comorbidity overall (22.0% of respondents). These data are consistent with other studies, which have shown an association between OAB and multiple factors including age, body mass index, marital status, high parity rate, smoking, diabetes, previous hysterectomy and post-menopausal status [
26,
35‐
37]. These results suggest that women in the Middle East have a range of risk factors that may increase their likelihood of experiencing OAB symptoms. These findings are in line with those from a global study, which estimated a higher prevalence of OAB in Asia compared with Europe, Africa, and North and South America [
3].
Despite the high prevalence of OAB symptoms and > 90% of women having symptoms of OAB-wet, our study revealed that only 13% were currently receiving treatment and 8% were previously treated; 74% of respondents had never received treatment, with the most common specified reason being ‘not bothered by symptoms.’ A previous survey of six European countries reported a treatment rate of approximately 27% and that the most common reason for not seeking help, for both men and women (61% and 56%, respectively), was the belief that no effective treatment was available [
4]. In addition, a small study conducted in Egypt (
n = 91) showed that only 4% of women with UUI sought medical advice [
29].
It has previously been suggested that many individuals with OAB are reluctant to seek medical care, a characteristic that has been attributed to social stigma and/or embarrassment associated with an inability to control the bladder; these individuals often endure the inconvenience and unpleasantness of symptoms [
4]. UUI in particular may have a severe impact on HRQoL, self-esteem, relationships and fear/anxiety. The severity of OAB symptoms appears to be associated with the adoption of non-medical coping strategies (e.g., controlling fluid intake and use of pads) rather than consulting a healthcare professional [
38,
39].
For individuals with OAB symptoms, the impetus to seek medical treatment may be multifactorial, e.g., the number of and/or bother from OAB symptoms and the age of the patient [
5]. It also appears that patients often consider the condition a normal part of aging or that they are unaware that effective treatment is available [
4,
40‐
42]. Indeed, there are currently several treatment modalities available, including education and lifestyle modification plus pharmacotherapy with oral antimuscarinic or beta-3 adrenoceptor agonist agents [
21,
22].
In 2018, the population in the Middle East region approached 450 million, with approximately 35% resident in Algeria, Egypt, Jordan and Lebanon [
43]. Considering the significant impact that OAB symptoms can have on HRQoL, these findings suggest that there is an unmet medical need in a significant number of women in the Middle East region. Strategies to improve treatment-seeking behavior (e.g., through reassurance, education and addressing the stigma associated with urinary symptoms) may therefore improve the management and health outcomes of women in the Middle East with OAB.
Limitations
In this cross-sectional survey, all data collected on symptoms were based on self-report without medical validation. In this disease area, the diagnosis of conditions involving lower urinary tract symptoms, including OAB, is often driven by patient self-report. The under-reporting of urinary symptoms has been observed in published research due to social stigma from inability to control the bladder [
40‐
42]. Therefore, participants may not have been comfortable sharing their symptoms with interviewers. However, the CATI method is considered more anonymous than a face-to-face interview; incontinence was assessed by responses to the OAB-V8 questionnaire meaning that women did not have to explicitly describe their symptoms. The methodology used here may have allowed for participants to be more open about their urinary symptoms without the worry of social stigma.
Of all the households contacted, 7.1% were identified as eligible and agreed to participate in the study. As participants were informed that it was a health-related telephone survey prior to consenting it is possible that unwell women were more engaged and likely to agree to participate in this survey (perhaps as an outlet to discuss their symptoms) compared with women who had good health. Additionally, most women who participated were aged 40–55 years (59.3%), and thus the generalizability of the results is somewhat limited to this age category.
Since self-reported information is susceptible to recall bias, there may also have been systematic errors caused by differences in the accuracy of the recollections retrieved by participants (regarding symptom bother during the past 4 weeks). In addition, some symptoms may not have been fully recognized by participants as being suggestive of OAB, a particular concern in developing countries. Furthermore, data for some demographic characteristics, including a history of gynecologic surgeries and deliveries associated with an increased risk of OAB symptoms, were not available in this survey. Finally, barriers to treatment and coping strategies were not explored in this study, nor was the compliance with treatment in those receiving current therapy.
Acknowledgements
The authors thank all participants for their involvement in the during study.