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Journal of Cancer Research and Clinical Oncology

Erschienen in:

01.08.2012 | Original Paper

The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis

verfasst von: Danni Shi, Shizhi Wang, Dongying Gu, Dongmei Wu, Meilin Wang, Haiyan Chu, Na Tong, Lan Ma, Dongyan Zhong, Zhengdong Zhang

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2012

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Abstract

Purpose

Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored 123-aa protein related to the cell-proliferation inhibition and/or cell-death induction activity. Many studies had reported the role of PSCA rs2294008 C > T and rs2976392 G > A polymorphisms on gastric cancer risk.

Methods

To investigate a more precise estimation of the relationships, we performed a meta-analysis on 9 case–control studies included 10,746 cases and 9,158 controls. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association.

Results

For PSCA rs2294008 C > T polymorphism, there was a significantly increased risk of gastric cancer in all genetic models (TT/TC vs. CC: OR = 1.61, 95 % CI = 1.35–1.91; TT vs. TC/CC: OR = 1.33, 95 % CI = 1.24–1.42). Similar results were also observed for PSCA rs2976392 G > A polymorphism (AA/AG vs. GG: OR = 1.69, 95 % CI = 1.24–2.31; AA vs. AG/GG: OR = 1.36, 95 % CI = 1.24–1.50). In the stratified analysis by ethnicity of rs2294008, an increased gastric cancer risk was found in both Asians (TT vs. TC/CC: OR = 1.31, 95 % CI = 1.22–1.42) and Europeans (TT/TC vs. CC: OR = 1.42, 95 % CI = 1.18–1.71). Furthermore, when stratified by clinicopathologic characteristics of tumor location and histology, a higher risk on non-cardia compared with cardia gastric cancer (TT vs. TC/CC: OR = 1.43, 95 % CI = 1.12–1.83) as same as diffused compared with intestinal gastric cancer (TT vs. TC/CC: OR = 1.29, 95 % CI = 1.13–1.49) was observed.

Conclusion

These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.

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Titel: The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis
verfasst von: Danni Shi
Shizhi Wang
Dongying Gu
Dongmei Wu
Meilin Wang
Haiyan Chu
Na Tong
Lan Ma
Dongyan Zhong
Zhengdong Zhang
Publikationsdatum: 01.08.2012
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2012
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-012-1210-6

Springer Medizin

The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis