Skip to main content
Erschienen in: Pediatric Cardiology 3/2008

01.05.2008 | Editorial

The Quest for the Unholy Grail

verfasst von: T. Kimball

Erschienen in: Pediatric Cardiology | Ausgabe 3/2008

Einloggen, um Zugang zu erhalten

Excerpt

In their study titled “Clinical Utility of Doppler Echocardiography in Assessing Aortic Stenosis Severity and Predicting Need for Intervention in Children,” Vlahos et al. [20] embark upon a noble quest attempting to use Doppler echocardiographic data to predict the “grail” of catheterization-derived aortic stenosis gradient. They discover that the catheterization gradient is best predicted by an average of the two Doppler peak instantaneous gradients obtained from the apical five-chamber view and a high parasternal view. Furthermore, although the negative predictive value of a peak instantaneous gradient from the high parasternal view of ≤55 mmHg is perfect, receiver operator characteristic curve areas are only modest so that the decision to intervene in a child with valvar aortic stenosis based on a single Doppler measurement or site is only marginally helpful. …
Literatur
1.
Zurück zum Zitat Baumgartner H, Stefenelli T, Niederberger J, Schima H, Maurer G (1999) “Overestimation” of catheter gradients by Doppler ultrasound in patients with aortic stenosis: a predictable manifestation of pressure recovery. J Am Coll Cardiol 33:1655–1661PubMedCrossRef Baumgartner H, Stefenelli T, Niederberger J, Schima H, Maurer G (1999) “Overestimation” of catheter gradients by Doppler ultrasound in patients with aortic stenosis: a predictable manifestation of pressure recovery. J Am Coll Cardiol 33:1655–1661PubMedCrossRef
2.
Zurück zum Zitat Beekman RH, Rocchini AP, Gillon JH, Mancini GB (1992) Hemodynamic determinants of the peak systolic left ventricular-aortic pressure gradient in children with valvar aortic stenosis. Am J Cardiol 69:813–815PubMedCrossRef Beekman RH, Rocchini AP, Gillon JH, Mancini GB (1992) Hemodynamic determinants of the peak systolic left ventricular-aortic pressure gradient in children with valvar aortic stenosis. Am J Cardiol 69:813–815PubMedCrossRef
3.
Zurück zum Zitat Bengur AR, Snider AR, Serwer GA, Peters J, Rosenthal A (1989) Usefulness of the Doppler mean gradient in evaluation of children with aortic valve stenosis and comparison to gradient at catheterization. Am J Cardiol 64:756–761PubMedCrossRef Bengur AR, Snider AR, Serwer GA, Peters J, Rosenthal A (1989) Usefulness of the Doppler mean gradient in evaluation of children with aortic valve stenosis and comparison to gradient at catheterization. Am J Cardiol 64:756–761PubMedCrossRef
4.
Zurück zum Zitat Bonow RO, Carabello BA, Kanu C et al (2006) ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation 114:e84–e231PubMedCrossRef Bonow RO, Carabello BA, Kanu C et al (2006) ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Circulation 114:e84–e231PubMedCrossRef
5.
Zurück zum Zitat Brown JW, Ruzmetov M, Vijay P, Rodefeld MD, Turrentine MW (2003) Surgery for aortic stenosis in children: a 40-year experience. Ann Thorac Surg 76:1398–1411PubMedCrossRef Brown JW, Ruzmetov M, Vijay P, Rodefeld MD, Turrentine MW (2003) Surgery for aortic stenosis in children: a 40-year experience. Ann Thorac Surg 76:1398–1411PubMedCrossRef
6.
Zurück zum Zitat Currie PJ, Seward JB, Reeder GS et al (1985) Continuous-wave Doppler echocardiographic assessment of severity of calcific aortic stenosis: a simultaneous Doppler–catheter correlative study in 100 adult patients. Circulation 71:1162–1169PubMed Currie PJ, Seward JB, Reeder GS et al (1985) Continuous-wave Doppler echocardiographic assessment of severity of calcific aortic stenosis: a simultaneous Doppler–catheter correlative study in 100 adult patients. Circulation 71:1162–1169PubMed
7.
Zurück zum Zitat Garcia D, Dumesnil JG, Durand LG, Kadem L, Pibarot P (2003) Discrepancies between catheter and Doppler estimates of valve effective orifice area can be predicted from the pressure recovery phenomenon: practical implications with regard to quantification of aortic stenosis severity. J Am Coll Cardiol 41:435–442PubMedCrossRef Garcia D, Dumesnil JG, Durand LG, Kadem L, Pibarot P (2003) Discrepancies between catheter and Doppler estimates of valve effective orifice area can be predicted from the pressure recovery phenomenon: practical implications with regard to quantification of aortic stenosis severity. J Am Coll Cardiol 41:435–442PubMedCrossRef
8.
Zurück zum Zitat Graham TP Jr, Bricker JT, James FW, Strong WB (1994) 26th Bethesda conference: recommendations for determining eligibility for competition in athletes with cardiovascular abnormalities. Task Force 1: congenital heart disease. J Am Coll Cardiol 24:867–873PubMed Graham TP Jr, Bricker JT, James FW, Strong WB (1994) 26th Bethesda conference: recommendations for determining eligibility for competition in athletes with cardiovascular abnormalities. Task Force 1: congenital heart disease. J Am Coll Cardiol 24:867–873PubMed
9.
Zurück zum Zitat Maron BJ, Zipes DP (2005) Introduction: eligibility recommendations for competitive athletes with cardiovascular abnormalities—general considerations. J Am Coll Cardiol 45:1318–1321PubMedCrossRef Maron BJ, Zipes DP (2005) Introduction: eligibility recommendations for competitive athletes with cardiovascular abnormalities—general considerations. J Am Coll Cardiol 45:1318–1321PubMedCrossRef
10.
Zurück zum Zitat Martin GR, Soifer SJ, Silverman NH, Dae MW, Stanger P (1987) Effects of activity on ascending aortic velocity in children with valvar aortic stenosis. Am J Cardiol 59:1386–1390PubMedCrossRef Martin GR, Soifer SJ, Silverman NH, Dae MW, Stanger P (1987) Effects of activity on ascending aortic velocity in children with valvar aortic stenosis. Am J Cardiol 59:1386–1390PubMedCrossRef
11.
Zurück zum Zitat Nadas AS (1977) Report from the Joint Study on the Natural History of Congenital Heart Defects. IV. Clinical course. Introduction. Circulation 56:I36–I38PubMed Nadas AS (1977) Report from the Joint Study on the Natural History of Congenital Heart Defects. IV. Clinical course. Introduction. Circulation 56:I36–I38PubMed
12.
Zurück zum Zitat Nadas AS, Weidman WH (1979) Pulmonary Stenosis, Aortic Stenosis, Ventricular Septal Defect: Clinical Course and Indirect Assessment. Report from the Joint Study on the Natural History of Congenital Heart Defects. American Heart Association, Dallas, TX Nadas AS, Weidman WH (1979) Pulmonary Stenosis, Aortic Stenosis, Ventricular Septal Defect: Clinical Course and Indirect Assessment. Report from the Joint Study on the Natural History of Congenital Heart Defects. American Heart Association, Dallas, TX
13.
Zurück zum Zitat Nishimura RA, Pieroni DR, Bierman FZ et al (1993) Second natural history study of congenital heart defects. Aortic stenosis: echocardiography. Circulation 87:I66–I72PubMed Nishimura RA, Pieroni DR, Bierman FZ et al (1993) Second natural history study of congenital heart defects. Aortic stenosis: echocardiography. Circulation 87:I66–I72PubMed
14.
Zurück zum Zitat Otto CM, Burwash IG, Legget ME et al (1997) Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation 95:2262–2270PubMed Otto CM, Burwash IG, Legget ME et al (1997) Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation 95:2262–2270PubMed
15.
Zurück zum Zitat Rosenhek R, Binder T, Porenta G et al (2000) Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 343:611–617PubMedCrossRef Rosenhek R, Binder T, Porenta G et al (2000) Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 343:611–617PubMedCrossRef
16.
Zurück zum Zitat Rosenhek R, Klaar U, Schemper M et al (2004) Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography. Eur Heart J 25:199–205PubMedCrossRef Rosenhek R, Klaar U, Schemper M et al (2004) Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography. Eur Heart J 25:199–205PubMedCrossRef
17.
Zurück zum Zitat Smith MD, Dawson PL, Elion JL et al (1985) Correlation of continuous wave Doppler velocities with cardiac catheterization gradients: an experimental model of aortic stenosis. J Am Coll Cardiol 6:1306–1314PubMedCrossRef Smith MD, Dawson PL, Elion JL et al (1985) Correlation of continuous wave Doppler velocities with cardiac catheterization gradients: an experimental model of aortic stenosis. J Am Coll Cardiol 6:1306–1314PubMedCrossRef
18.
Zurück zum Zitat Smith MD, Dawson PL, Elion JL et al (1986) Systematic correlation of continuous-wave Doppler and hemodynamic measurements in patients with aortic stenosis. Am Heart J 111:245–252PubMedCrossRef Smith MD, Dawson PL, Elion JL et al (1986) Systematic correlation of continuous-wave Doppler and hemodynamic measurements in patients with aortic stenosis. Am Heart J 111:245–252PubMedCrossRef
19.
Zurück zum Zitat Uebing A, Steer PJ, Yentis SM, Gatzoulis MA (2006) Pregnancy and congenital heart disease. Br Med J 332:401–406CrossRef Uebing A, Steer PJ, Yentis SM, Gatzoulis MA (2006) Pregnancy and congenital heart disease. Br Med J 332:401–406CrossRef
20.
Zurück zum Zitat Vlahos AP, Marx GR, McElhinney D et al (2007) Clinical utility of Doppler echocardiography in assessing aortic stenosis severity and predicting need for intervention in children. Pediatr Cardiol Vlahos AP, Marx GR, McElhinney D et al (2007) Clinical utility of Doppler echocardiography in assessing aortic stenosis severity and predicting need for intervention in children. Pediatr Cardiol
21.
Zurück zum Zitat Wagner HR, Ellison RC, Keane JF, Humphries OJ, Nadas AS (1977) Clinical course in aortic stenosis. Circulation 56:I47–I56PubMed Wagner HR, Ellison RC, Keane JF, Humphries OJ, Nadas AS (1977) Clinical course in aortic stenosis. Circulation 56:I47–I56PubMed
Metadaten
Titel
The Quest for the Unholy Grail
verfasst von
T. Kimball
Publikationsdatum
01.05.2008
Verlag
Springer-Verlag
Erschienen in
Pediatric Cardiology / Ausgabe 3/2008
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-008-9217-0

Weitere Artikel der Ausgabe 3/2008

Pediatric Cardiology 3/2008 Zur Ausgabe

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 Adipositas Nachrichten

Der als Antidiabetikum sowie zum Gewichtsmanagement zugelassene Wirkstoff Tirzepatid hat in Studien bei adipösen Patienten auch schlafbezogene Atmungsstörungen deutlich reduziert, informiert der Hersteller in einer Vorab-Meldung zum Studienausgang.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.