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Erschienen in:
27.01.2016
The randomized control trial of the effects of testosterone and a nutritional supplement on hospital admissions in undernourished, community dwelling, older people
Erschienen in: The journal of nutrition, health & aging | Ausgabe 7/2016
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Objective
In a pilot single centre study we found that treatment of undernourished older, community dwelling people for one year with oral testosterone (placebo-controlled) and a nutritional supplement (no control) was associated with a significant reduction in hospitalizations. A larger, multicentre study was conducted to investigate further this potentially important finding.
Design
One year, randomized, placebo-controlled, multicentre, double-blind, trial.
Setting
Community.
Participants
53 undernourished men and women aged 65 years and older.
Intervention
Oral testosterone undecanoate (40 mg/day women, 160 mg/day men) and high energy oral nutritional supplement (2108-2416 kJ/day) or placebo medication and low energy (142–191 kJ/day) “placebo” oral nutritional supplementation.
Measurements
Hospital admissions, falls and other variables were assessed.
Results
53 subjects were recruited (64% male and mean age 77 years), which was substantially less than planned. Sixteen subjects (30%) were admitted to hospital at least once, with a total of 29 admissions. Eight subjects (32%) in the placebo arm were admitted to hospital, whilst in the intervention group also there were eight (29%) subjects admitted to hospital during the study period. There was no difference in the number of hospitalisations (P = 0.842), length of hospitalization (P=0.645) or quality of life [mental health P=0.195 and physical health P=0.451) between the treatment arms.
Conclusions
In undernourished older people, treatment with testosterone and a nutritional supplementation did not reduce the number and length of hospitalisations or improve quality of life.